Parasympathetic ( Agonists And Antagonists) Flashcards
A nonselective muscarinic agonist
Pilocarpine
Pilocarpine is used to treat
Xerostomia and glaucoma
Ganglionic receptors are selectively blocked by
Mecamylamine
NMJ receptors are selectively blocked by
Atracurium
Direct Acting cholinergic agonists
Acetylcholine
Bethanechol
Carbachol(carbamylcholine)
Pilocarpine
Nicotine
Choline esters include
Acetylcholine
Carbachol
Bethanechol
Naturally occurring alkaloids include
Nicotine
Pilocarpine
Acetylcholine has dual activity or binds two types of receptors
Muscarinic and Nicotinic
Actions of Ach
Decrease in heart rate and cardiac output
Decrease in bp
Increase in salivary secretion
Increase in gastric acid secretion
Stimulates intestinal secretions and motility
Bethanechol acts on what receptor
Muscarinic receptors
Bethanechol majorly acts on?
Smooth musculature of the bladder and GI tract
Carbachol acts on both?
Muscarinic and Nicotinic receptors
Adverse effects of pilocarpine
Blurred vision
Night blindness
Brow ache
Profuse sweating and salivation
Indirect-acting cholinergic agonists: Anticholinesterase agents(reversible) include:
Edrophonium
Physostigmine
Neostigmine
Pyridostigmine
Tacrine, donepezil, rivastigmine, and galantamine.
A prototype short acting AChE inhibitor is
Edrophonium
Use of edrophonium
Used in the diagnosis of Myasthenia gravis
Reactivation of acetylcholinesterase is by the use of
Pralidoximine
Antimuscarinic agents
Atropine
Scopolamine
Aclidinium
Glycopyrrolate
Ipratropium
Tiotropium
Tropicamide
Cyclopentolate
Benztropine
Trihexyphenidyl
Oxybutynin
Darifenacin
Fesoterodine
Solifenacin
Tolterodine
Trospium
The most effective drug for motion sickness
Scopolamine
Non depolarizing(competitive) blockers
Curare
Mivacurium
Cisatracurium
Pancuronium
Rocuronium
Vecuronium
Depolarizing agents (NMB)
Succinylcholine
