Parasitic Infection Of Hepatobiliary System Flashcards
Amoebic liver abscess - laboratory diagnosis and treatment
∆ Laboratory diagnosis
1) microscopy of liver pus cells obtained from liver abscess.
2) detection of Lectin antigen
3) detection of antibodies formed against lectin antigen
4) molecular diagnosis using PCR and real time PCR 18S rRNA
5) radiological examination such as ultra sonography or CT scan or MRI.
∆ Treatment
1) metronidazole for tissue agents (liver).
2) iodoquinol for luminous agents
Amoebic liver abscess - clinical features pathogenesis and complications
Admission is by injection of food and water contaminated by cyst of entamoeba histolytica.
This cysts develop into tropozoites which attached to intestinal mucosa.
Liver abscess is formed due to inflammatory response surrounding to hepatocytes which comprises of necrotic hepatocytes and a few amoebic tropozoites. Liver abscess pus is thick chocolate brown in colour.
Clinical presentation is tender hepatomegaly and fever with weight loss, sweating and weakness and rarely jaundice.
Complications can ok due to rupture of liver abscess which can be on the skin of abdominal wall or into the lungs or below the diagram and left side abscess of liver into stomach or pericardial cavity.
Human Echinococcosis
1) cystic Echinococcosis- E granulosus
2) alveolar Echinococcosis- E multilocularis
3) neotropical Echinococcosis - e vogeli or e oligarthrus.
Life cycle includes definite host commonly dogs and intermediate host commonly sheep and man.
