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Parasite and Helminth Drugs > Parasite and Helminth Drugs > Flashcards

Parasite and Helminth Drugs Flashcards

1
Q

<p>Clinical App:

nematodes generally but can be used in certain cestode and trematode infections</p>

A

<p>Benzimidazoles</p>

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2
Q

<p>Stage Killed:

Eggs, Larvae, Adults </p>

A

<p>Benzimidazoles</p>

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3
Q

<p>Common Serious Adverse Rx:

GI disturbance and BM suppression</p>

A

<p>Benzimidazoles</p>

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4
Q

<p>Mechanism of Action:

1. Inhibit microtubule polymerization
2. Inhibit energy production</p>

A

<p>Benzimidazole</p>

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5
Q

<p>Resistance:

1. Switch Beta tubulin isotype
2. B tubulin point mutation</p>

A

<p>Benzimidazole</p>

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6
Q

<ol>
<li>Nematodes</li>
(Onchoceriasis when given in combo with steroids)
(Lymph filariasis when given in combo with benzimidazoles)
<li>Ineffective against trematodes and cestodes</li>
</ol>

A

<p>Ivermectin</p>

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7
Q

Stage Killed:

Microfilariae

A

Ivermectin

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8
Q

Common Serious Adverse Rxns:

  1. Mazzotti-like rxn due to dying microfilariae (use steroids)
  2. Contraindicated in onchocerciasis
A

Ivermectin

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9
Q

Mechanism of Action:

Activates glutamate-gated Cl- channels causing flaccid paralysis

A

Ivermectin

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10
Q

Resistance:

  1. P-glycoprotein
  2. Mutation in channel
A

Ivermectin

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11
Q

Clinical App:

Nematodes
Loiasis) and (Lymph filariasis in combo with benzimid

A

DEC

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12
Q

Stage Killed:

Microfilariae and adults

A

DEC

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13
Q

Common Searious Adverse Rxns:

  1. Mazzotti-like rxn due to dying microfilariae (use steroids)
  2. Contraindicated in onchocerciasis
A

DEC

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14
Q

Mechanism of Action:

Stimulate host immune response

A

DEC

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15
Q

Resistance:

Typically not a problem

A

DEC

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16
Q

Clinical App:

Nematodes in GI lumen

A

Pyrantel

17
Q

Stage killed:

Larvae and adults

A

Pyrantel

18
Q

Common Serious Adverse Rxns:

GI disturbances and headaches

A

Pyrantel

19
Q

Mechanism of Action:

  1. Stimulate nicotinic receptor
  2. Increase ACh release and spastic paralysis
A

Pyrantel

20
Q

Clinical App:

  1. Trematodes (schistosomiasis)
  2. Cestodes

Ineffective against nematodes

A

Praziquantel

21
Q

Stage Killed:

Immature stages and adults

A

Praziquntel

22
Q

Common Serious Adverse Rxns:

  1. GI disturbances and headaches
  2. Containdicated in intraocular cysticercosis
A

Praziquantel

23
Q

Mechanism of Action:

Increase membrance permeability to Ca ++ with spastic paralysis

A

Praziquantel

24
Q

Resistance:

Typically not a problem

A

Pyrantel

25
Q

Resistance:

Typically not a problem
Possible mutation in VGCC

A

Praziquantel

Parasite and Helminth Drugs (1 decks)

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