Paraneoplastic syndromes

Question 1

ACTH or ACTH-like peptide

Answer 1

Cushing’s syndrome - small cell lung carcinoma

Question 2

ADH

Answer 2

SIADH – small cell lung carcinoma and intracranial neoplasms

Question 3

PTHrP

Answer 3

hypercalcemia – squamous cell lung carcinoma, renal cell carcinoma, breast cancer

Question 4

1,25 - (OH)2 D3 (calcitriol)

Answer 4

hypercalcemia – hodgkin’s lymphoma, some non-Hodgkin’s lymphomas

Question 5

Erythropoietin

Answer 5

polycythemia – renal cell carcinoma, hemangioblastoma, hepatocellular carcinoma, pheochromocytoma

Question 6

Antibodies against presynaptic Ca2+ channels at NMJ

Answer 6

Lambert-Eaton syndrome – small cell carcinoma