Paraneoplastic syndromes Flashcards
What causes fever?
IL-1
What hormone is responsible for hypokalemia and hyperglycemia in cancer patients?
ectopic ACTH - cushings
What can cause hypercalcemia in cancer patients?
- metastatic disease of bone
- PTH mimic molecule by epithelial tumors
What tumors are notorious for causing a patient to have hypocalcemia?
- lung, breast, prostate
What tumor produces anti-Hu antibodies?
small cell lung cancer
What are some symptoms that anti-hu antibodies cause?
- sensory neuropathies
- limbic encephalitis - seizures, memory deficit
- autonomic neuropathies - loss of vasc tone
- vision loss - loss of retinal photoreceptor
- motor neuron disease
What cancers are associated with anti-leucine zipper protein yo? what happens as a result?
- =breast cancer and hodkins lymphoma
- progressive cerebellar degeneration
What tumor is associated with opsoclonus myoclonus, or nonvoluntary spasms of ocular muscles?
neuroblastoma in children
What is a common paraneoplastic syndrome associated with thymomas?
neuromuscular junction disorders
What is eaton lambert syndrome?
- associated with small cell lung cancer
- symptoms are like myasthenia gravis but are overcome with exercise
What is subacute motor neuropathy?
slow developing LMN weakness
-VERY strongly associated with cancer - lymphoma
What tumors are notorious for causing iron deficient anemias?
colorectal - because they cause bleeding into GI
What tumors cause autoimmune hemolytic anemia?
B cell neoplasms
solid tumors in old people
What is the most common cause of venous thrombosis or trousseau syndrome?
carcinoma of the pancreas
Which cancers cause DIC?
- adenocarcinoma
- APL
