Paraneo syndromes Flashcards
Acanthosis nigricans
Hyperpigmented velvety plaques in axilla and
neck
Gastric adenocarcinoma and other visceral
malignancies (but more commonly associated
with obesity and insulin resistance)
Sign of Leser-Trélat
Sudden onset of multiple seborrheic keratoses
GI adenocarcinomas and other visceral
malignancies
Hypercalcemia
PTHrP
Squamous cell carcinomas of lung, head, and
neck; renal, bladder, breast, and ovarian
carcinomas
Hypercalcemia
inc. vit D3
Lymphoma
Cushing syndrome
inc. ACTH
Small cell lung cancer
SIADH
inc ADH
Small cell lung cancer
Polycythemia
inc. erythropoietin
RCC, HCC, hemangioblastoma, pheochromocytoma, leiomyoma
Pure red cell aplasia
anemia with low reticulocytes
Thymoma
Good syndrome - hypogammaglobulinemia
Thymoma
Trousseau syndrome - migratory superficial thrombophlebitis
Adenocarcinomas, esp. pancreatic
Nonbacterial thrombotic (marantic) endocarditis
Deposition of sterile platelet thrombi on heart valves
Adenocarcinomas esp. pancreatic
Anti-NMDA receptor
encephalitis
Psychiatric disturbance, memory deficits,
seizures, dyskinesias, autonomic instability,
language dysfunction
Ovarian teratoma
Opsoclonusmyoclonus
ataxia
syndrome
“Dancing eyes, dancing feet”
Neuroblastoma (children), small cell lung
cancer (adults)
Paraneoplastic cerebellar degeneration Antibodies against Hu, Yo, and Tr antigens in Purkinje cells
Small cell lung cancer, gynecologic and breast
cancers, and Hodgkin lymphoma
Paraneoplastic
encephalomyelitis
Antibodies against Hu antigens in neurons
Small cell lung cancer
