Paramedic drugs (second half) Flashcards
Tranexamic acid (TXA) indications
TIME CRITICAL injury with sign. internal/external haemorrhage suspected
TXA actions
Anti-fibrinolytic: reduces the breakdown of blood clot
TXA contraindications
1) isolated head injury
2) bleeding stopped
TXA side effects
Rapid injection rarely causes hypotension
TXA route
IV only
How to give TXA?
SLOWLY over 10 mins
TXA dose in adult?
1g (in 10mls)
TXA max dose?
1g
Do you repeat dose of TXA?
No
Syntometrine actions
stimulates contraction of uterus
syntometrine onset of action
7-10 mins
syntometrine contraindications (3)
- known hypersensitivity to syntometrine
- active labour
- severe cardiac/liver/kidney disease
Route of syntometrine
IM
What is the initial dose of syntometrine?
500mcg of ergometrine
5 units of oxytocin
What is the initial dose of syntometrine?
500mcg of ergometrine
5 units of oxytocin in 1ml
do you give repeat doses with syntometrine?
no
0.9% sodium chloride indications (6)
- medical conditions without haemorrhage
- medical conditions with haemorrhage
- trauma related haemorrhage
- burns
- limb crush injury (adult)
- flush (post drug administer, IV/IO cannula)
0.9% sodium chloride actions
increase vascular fluid volume
which raises CO
improves perfusion
0.9% sodium chloride route
IV
IO
Dose for sodium chloride flush
2-5ml PRN
dose of sodium chloride if infusing glucose
10-20ml PRN
dose of NaCl for gen med conditions without haemorrhage e.g. anaphylaxis, DKA, dehydration
250ml
Max dose: 2L
Repeat dose: 250ml
Dose interval: PRN
dose of NaCl with sepsis (clinical signs of infection AND SBP <90 AND tachypnoea
1L
Max dose: 2L
Dose interval: 30mins
dose of NaCl for med conditions with haemorrhage (SBP <90 and signs of poor perfusion)
250ml
max dose: 2L
Dose interval: PRN
Repeat dose: 250ml
dose of NaCl in blunt trauma/head trauma/penetrating limb trauma (SBP <90 and signs of poor perfusion)
250ml
max dose: 2L
interval dose: PRN
Repeat dose: 250ml
dose of NaCl for penetrating torso trauma (SBP <60 and signs of poor perfusion)
250ml
max dose: 2L
dose interval: PRN
repeat dose: 250ml
dose of NaCl for burns if
- total body surface area (TBSA) between 15-25% and time to hosp >30 mins
- TBSA >25%
1L
max dose: 1L
dose of NaCl in limb crush injury
2L
Max dose: 2L
Indications for salbutamol (4)
- acute asthma attack
- expiratory wheeze assoc with allergy, anaphylaxis, smoke inhalation, lower airway cause
- exacerbation COPD
- SOB due to LVF (secondary Rx)
Action of salbutamol
relaxant effect on smooth muscle in medium/smaller airways
those in spasm in acute asthma attack
which receptors do salbutamol work on?
selective b2 adrenoreceptor stimulant
care should be given when administrating salbutamol to pts with (6)
- HTN
- angina
- overactive thyroid
- late pregnancy (relaxes uterus)
- severe HTN may occur in pt on BB
- COPD is possibility then limit nebs to six mins
side effects of salbutamol (8)
- tremor
- tachycardia
- palps
- headache
- feeling of tension (lol)
- peripheral vasodilation
side effects of salbutamol (8)
- tremor
- tachycardia
- palps
- headache
- feeling of tension (lol)
- peripheral vasodilation
- muscle cramps
- rash
what should be given in acute severe or life-threatening asthma after the first dose of salbutamol
ipatropium
in more severe resp attacks what could be used following initial relief of salbutamol
steroids (IM/PO)
further nebs
route of salbutamol
nebulise with 6-8L per minute of oxygen
dose of salbutamol
5mg in 5ml or 2.5ml
Max dose: no limit
Dose interval: 5 mins
repeat dose: 5mg
paracetamol actions (2)
- analgesic
2. antipyretic
paracetamol oral dose
1g
2x500mg tab
dose interval: 4-6hrs
max dose: 4g in 24hrs
paracetamol IV infusion dose
1g in 100ml
given over 5-10 mins
dose interval: 4-6 hrs
max dose: 4g in 24hrs
ondansetron indications (2)
- prevention/treatment opiate induced nausea/vomiting
2. treatment of n/v
action of ondansetron
anti-emetic
blocks 5-HT receptors
centrally and in GI tract
cautions with ondansetron
QT interval prolongation
route of ondansetron (2)
- Slow IV injection over 2 mins
2. IM
dose of ondansetron
4mg in 2ml
max dose: 4mg
narloxone hydrochloride (narcan) indications
opioid overdose
respiratory arrest
action of narcan
antagonism of effects (incl. resp depression) of opioid durgs
routes of narcan
IV
IO
IM (undiluted to outer aspect of thigh or upper arm)
dose of narcan (IV/IO)
400 mcg
in 1ml (slowly) max dose: 4400mcg dose interval: 3 mins repeat doses: 400mcg
morphine sulphate actions
- strong opioid analgesic
2. histamine release follows administration -> vasodilatory effects
morphine sulphate bad actions
depress respiration
induce hypotension
routes of morphine
IV/IO
PO
IM/SC
dose of morphine IV/IO
10mg in 10ml
max dose: 20mg
dose interval: 5 mins
repeat dose: 10mg
dose of morphine (PO)
20mg in 10ml
max dose: 40mg
dose interval: 60 mins
repeat dose: 20mg
dose of morphine (IM/SC)
10mg in 1ml
max dose: 20mg
dose interval: 60 mins
repeat dose: 10mg
misoprostol indications (2)
- PPH within 24 hrs of delivery (where uterine massage has failed)
- miscarriage with life-threatening bleeding and confirmed diagnosis
when syntometrine and ergometrine are contraindicated in HTN (BP >140/90) then use
misoprostol
action of misoprostol
stimulates contraction of uterus
onset of misoprostol action
7-10 mins
routes of misoprostol
oral
rectal
dose of misoprostol (PO)
600mcg
3x200mcg tabs
max dose is 600mcg
dose of misoprostol (rectal)
1mg
5x200mcg tabs
max dose: 1mg
metoclopramide (maxolon) indications
- treatment of nausea/vomiting in adults 20 and over
2. prevention/treatment of nausea and vomiting following morphine
action of metoclopramide
anti-emetic
acts centrally and on GI tract
routes of metoclopramide
IV
dose of metoclopramide
10mg in 2ml
max dose is that
side effects of metoclopramide
extra-pyramidal effects (more common in children/young adults)
- drowsy and restless
- cardiac conduction abnorms with IV
- diarrhoea
- rash