Paramedic Drug Week 16 Flashcards
Labetalol (Normodyne, Trandate)
Class
Selective alpha (a1) and non-selective beta(b1-b2)-adrenergic blocker
Labetalol (Normodyne, Trandate)
Mechanism of Actions
Reduces blood pressure without reflex tachycardia; total peripheral resistance is reduced without significant alteration in cardiac output
Labetalol (Normodyne, Trandate)
Indications
Moderate to severe hypertension
Labetalol (Normodyne, Trandate)
Contraindications
bradycardia, bronchial asthma, cardiogenic shock, CHF,
second- or third-degree AV block
Labetalol (Normodyne, Trandate)
Adverse Reactions
Headache, dizziness, dyspnea, hypotension, ventricular arrhythmias
Labetalol (Normodyne, Trandate)
Drug Interactions
Trandate may block bronchodilator effects of beta-adrenergic agonists. NTG may augment hypotensive effects of Labetalol.
Labetalol (Normodyne, Trandate)
Adult IVP Dosage
5-20 mg Slow IVP over 2 min, can give additional dosages of 10-
40 mg at 10 minute intervals.
Labetalol (Normodyne, Trandate)
Adult Infusion Dosage
Infusion: 2 mg/min titrated to acceptable
supine blood pressure
Labetalol (Normodyne, Trandate)
Pediatric
Safety has not been established
Labetalol (Normodyne, Trandate)
Onset
Less than 5 Minutes
Labetalol (Normodyne, Trandate)
Peak Effect
Variable
Labetalol (Normodyne, Trandate)
Duration
3-6 hours
Labetalol (Normodyne, Trandate)
Special Considerations
Continuous monitoring of BP, pulse rate, and ECG. Observe for signs of CHF, bradycardia, and bronchospasm.
Labetalol (Normodyne, Trandate)
Special Considerations
Body Position
Should only be administered when the patient is supine.
Furosemide (Lasix)
Class
Loop diuretic