Paracetamol Overdose Flashcards

1
Q

Define paracetamol overdose

A

> 4g (or 75mg/kg)

in 24h

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2
Q

What are the risk factors of paracetamol overdose?

A
  • Chronic alcohol abusers
  • Patients on enzyme-inducing drugs (e.g. anticonvulsants)
  • Malnourished
  • Anorexia nervosa
  • HIV
  • Paracetamol overdose is commonly associated with ingestion of large amounts of alcohol
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3
Q

What are the symptoms of paracetamol overdose?

A
Hepatotoxicity 2-3 days after
ingestion
• Asymptomatic
• N&V
• Abdominal pain
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4
Q

What are the signs of paracetamol overdose?

A
  • RUQ tenderness
  • Jaundice *
  • Hepatic encephalopathy *
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5
Q

What investigations are carried out for paracetamol overdose?

A
  • paracetamol levels

* FBC, U&Es, Glucose, LFTs, Clotting Screen, Lactate and ABG

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