Paracetamol Flashcards

1
Q

Hvordan metaboliseres paracetamol?

A

Glukuronidering og glukuronidyltransferase.
Sulfatkonjugering.
Oksidering og CYP450 -> NAPQI, metemoglobinformering.

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2
Q

Symptomer: hund

A

GI-symptomer (kvalme, oppkast, anoreksi), levernejrose, takykardi, svakhet, skjelvinger.

Store inntak -> methemoglobinemi, cyanose.

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3
Q

Symptomer: katt

A

Methemoglobinemi hovedproblem.

Anoreksi, CNS-depresjon, takykardi, svakhet, cyanose, methemoglobinemi, dyspne, koma, leverskade.

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4
Q

Behandling

A

Ventrikkeltømming og kull < 2t
Acetylcystein
Katter behandles uansett, monitorerer methemoglobinemi og leverenzymer.

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