Papillary Lesions

Question 1

Intraductal papilloma
2 types
RR of carcinoma

Answer 1

Small duct papilloma - in TDLU, usually mutiple, RR 3 fold
Large duct papilloma - centrally in lactiferous duct, usually solitary, RR 2 fold

Question 2

Papilloma involved by DCIS
Criteria for ADH and DCIS

Answer 2

if low grade and </= 3 mm : ADH
if intermediate to high grade or >3 mm : DCIS

Question 3

Encapsulated papillary carcinoma
Myoepithelial cells?

Answer 3

None present both in the periphery and in fronds

Question 4

Solid papillary carcinoma
Classification
IhC
ER/PR, Her2

Answer 4

Solid papillary CIS - if WC
solid papillary carcinoma with invasion or invasive solid papillary carcinoma - if with infiltrating strands or ragged borders
Myoepithelial cells sparse but may be present
Can have neuroendocrine differentiation in 45% of cases (+) synapto, chromo
Almost all (+) ER/PR and (-) HER2

Question 5

Invasive papillary carcinoma
Myoeps?
Hormone status

Answer 5

Absent myoeps
Almost all (+) ER/PR and (-) HER2