Paper 6: SC Systems Immunology, Colorectal Cancer

Question 1

CMS1 tumours (5)

Answer 1

• infiltration of cytotoxic T cells, NK cells, and macrophages
• highly immunogenic
• have high mutation load
• PDL1 blocking phagocytic cells
• type of colorectal cancer

Question 2

CMS4 tumours (3)

Answer 2

• infiltration of myeloid derived suppressor cells
• marked by inflammation and colitis
• type of colorectal cancer

Question 3

what changes were made to the colon, blood, spleen, and BM immune system in tumour-bearing mice

Answer 3

• tumour-enriched monoyctes (pTEMs) not normally present emerged
• emergence of immuno-suppresant cells and loss of cDCs, etc

Question 4

how were the populations of phagocytes altered in tumour-bearing mice

Answer 4

• expansion of the Ly6C+ macrophages in tumour setting

Question 5

do tumours have an impact on the gene expression profile of circulating monocytes

Answer 5

• the do have an impact and likely impact expression of transcription factor and immuno-suppressant genes

Question 6

what do pTEMs do (2)

Answer 6

• turn off T cell activity during cancer
• act as an immuno-suppressant