Paper 1 CRQ Flashcards

1
Q

What neurotransmitters are released by postganglionic sympathetic fibres

A

Noradrenaline

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2
Q

When do postganglionic sympathetic fibres not release noradrenaline

A

Nerves innervating adrenal medulla and sweat glands release Acetylcholine

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3
Q

How is dopamine produced

A

Tyrosine is converted to L-DOPA by tyrosine hydroxylase. L-DOPA is then converted to dopamine by DOPA decarboxylase. Dopamine Beta Hydroxylase converts dopamine into noradrenaline

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4
Q

How is adrenaline synthesised from Noradrenaline

A

action of Phenylethanolamine N methyltransferase (PNMT)

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5
Q

Are G protein coupled receptors metabotropic or inotropic

A

Metabotropic

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6
Q

Are Ligand gated ion channels metabotropic or inotropic

A

Inotropic

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7
Q

In a pedigree what does a square denote

A

Live male

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8
Q

In a pedigree what does a circle denote

A

Live female

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9
Q

In a pedigree how is a marriage or partnership shown

A

Horizontal line between 2 symbols.

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10
Q

In a pedigree how is a consanguinous marriage shown

A

Double horizontal line between 2 symbols

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11
Q

In a pedigree how are deceased people denoted

A

A diagonal line through their symbol

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12
Q

What is a proband in genetic testing

A

First person to receive genetic counselling

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13
Q

Aniridia gene

A

PAX 6

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14
Q

What are the optics of the OCT

A

A broadband low coherence light source is directed at the desired target. a beam splitter is used to simultaneously direct the same light source at a reference mirror. the reflected light from both the desired target and the reference mirror are directed onto a detector and the interference pattern analysed using low coherence inferometry to construct an image of the desired target

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15
Q

What measurements are required to calculate IOL power with Hoffer Q and SRT/K

A

Axial length and Keratometry values

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16
Q

What measurements are required to calculate IOL power with Holladay 1 formula.

A

Axial length and Keratometry values

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17
Q

What measurements are required to calculate IOL power with haigis formula

A

Axial length, Keratometry and pre operative AC depth

18
Q

What measurements are required to calculate IOL power with Holladay 2 formula

A

uses 7 measurements

19
Q

When is the Hoffer Q formula used

A

When AL is <21.5mm

20
Q

How can you tell which is the steep axis of the cornea on the biometry

A

Steep axis at 90 degrees to the axis of negative cylinder. Steep axis = higher K value

21
Q

ICG absorption and emission wavelengths

A

Absorption 805nm
Emission 835nm

22
Q

What is the function of macula xanthophyll

A

found in inner and outer plexiform layers is thought to play a role in limiting damage to the photoreceptors from high energy short wavelength light

23
Q

Which plasma protein is IGC tightly bound to

A

alpha 1 lipoproteins- 80% bound to globulin- total binding 98%

24
Q

How is ICG dye excreted

A

Hepatobiliary excretion- secreted into bile. If present in circulation at 30 mins means reduced hepatic function

25
Q

What are the optics of CT

A

An xray tube rotates around the patient taking hundreds of Xrays from different angles which are detected by detector plates and processed by computers to produce the CT images

26
Q

Which culture medium is good for fungi

A

Sabouraud agar- can take upto 3 weeks to culture a fungus

27
Q

Which stains are used for fungi

A

These 2 need fluorescence imaging
1) Calcoflour white
2) Acridine orange

These 2 do not need fluorescence imaging
1) PAS
2) Gomori Methanamine Silver stain

28
Q

How to classify fungi causing keratitis

A

Filamentous fungi
Yeast like organisms

29
Q

How to further classify filametous fungi

A

Septate and Non septate organisms
Septate organisms (Aspergillus, Fusarium, Acremonium)

30
Q

How to correct symptomatic anisometropia following unilateral cataract surgery

A

1) Remove the cataract in the fellow eye
2) Isiekonic lenses- alter image size to compensate for small degrees of microtropia
3) Contact lenses reduce relative spectacle magnification

31
Q

What effect does nucleosclerosis have on the human lens

A

Increased refractive index of the lens resulting in increased myopia

32
Q

Where is the second focal point in Gullstrand schematic eye

A

On the retina

33
Q

Where does the first and second principal point lie in Gullstrand schematic eye

A

Close together in the AC where the principal planes meet the principal axis

34
Q

Where does the first nodal point lie in Gullstrand schematic eye

A

immediately anterior to posterior pole of lens

35
Q

Where does the second nodal point lie in Gullstrand schematic eye

A

immediately posterior to the posterior pole of the lens- in the vitreous

36
Q

Where does the nodal point in the reduced Schematic eye lie

A

At the posterior lens material

37
Q

Normal AC/A ratio

A

3:1 to 5:1

38
Q

What is the gradient method of calculating AC/A ratio

A

Takes measurements at the same distance but induces changes in accommodation with different lenses. IPD calculation not needed

39
Q

What is the heterophoria method of calculating AC/A ratio

A

change in deviation for near versus distance. Needs IPD

40
Q

What principle underlies the use of Goldmann Applanation Tonometry

A

Imbert-Fick principle
P=F/A