Panget Pharma PLE Flashcards
Pumasa sa September PLE 2021
Thrombolytic therapy can be started after a few hours after the cerebral ischemic attack. Select the appropriate agent. A. Enoxaparin B. Clopidogrel C. Retaplase D. Tirofibrin
C. Retaplase
Rationale:
A. Enoxaparin- LMWH (anti-thrombin)
B. Clopidogrel- ADP receptor antagonist (anti-coagulant)
D. Tirofibrin- GPIIb-IIIa receptor
Which of the following is NOT seen in the use of Acetazolamide?
A. Prevents the secretion of H+ in the tubule.
B. Acidify the urine
C. Inhibits carbonic anhydrase
D. Promotes Na+ AND K+ excretion.
B. Acidify the urine
Rationale:
Alkanize bring by inhibiting secretion of H+ in tubules
Kim Sia self medicated with prednisone for her allergy. You were alarmed because of the following side effects EXCEPT? A. Hypocalcemia B. Hyperglycemia C. Hypertension D. Better wound healing
D. Better wound healing
Rationale:
POOR wound healing
Select the inhibitor of Dipeptidyl Peptidase-4 (DPP-4 inhibitor) A. Pramlitide B. Liraglutide C. Glibenclamide D. Sitagliptin
D. Sitagliptin
Rationale:
A. Pramlitide- Amylin analog
B. Liraglutide- GLP1 analogue
C. Glibenclamide- SU
The use of spironolactone has been associated with which of the following side effects? A.Hypermagnesemia B Hyperkalemia C. Hyperuricemia D. Hypernatremia
B Hyperkalemia
Rationale:
All will be decreased ( Na, Ca, Mg) except for Potassium
Which of the following is given for morphine addiction. It is usually started when the morphine withdrawal symptoms started. A. Fentanyl B. Hydrocodone C. Tramadol D. Buprenorphine
D. Buprenorphine
Rationale:
Opiods
A. Fentanyl
B. Hydrocodone
C. Tramadol
Antibiotic when given concomitantly with Digoxin causes increase toxicity from Digoxin. This can be explained by.
A. Competes with digoxin binding site
B. Favors digoxin binding to cardiac cells
C. Destroying enteric bacteria that naturally inactivates Digoxin.
D. Impairs renal excretion of Digoxin.
C. Destroying enteric bacteria that naturally inactivates Digoxin.
Which of the following is NOT given in patients with Esophageal Varices. A. Ocreotide B. Calcium channel blockers C. Talipressin D. Beta blockers
B. Calcium channel blockers
Rationale:
A. Ocreotide: Main Tx
C. Talipressin: Vasopressin derivative- Vasoconstriction
D. Beta blockers: Portal hypertension
Linezolid has no activity against. A. uncomplicated UTI B. Nasocomial pneumonia C. MRSA infections D. Intraabdominal infection by Enterococcus.
A. uncomplicated UTI
Rationale:
Sobra naman daw kaaga ibigay ang linezolid sa UTI dapat milder lang haha.
Belle Nadora is complaining of increased facial hair (male pattern distribution). She was given Spirinolactone . This drug is effective by.
A. Being an anti-gonadotrophin
B. Inhibiting androgen synthesis
C. Inhibiting 5 alpha reductase
D. Being an androgen receptor antagonists
D. Being an androgen receptor antagonists
Rationale:
MOA of Spirinolactone is to competitively binds the Aldosterone receptor preventing the hormone to bind to its receptor.
Effect of morphine at the mu receptor is responsible for the following EXCEPT? A. Sedation B. Respiratory Depression C. Analgesia D. Miosis E. None of the above
E. None of the above
Select the quinolone that has been associated with the development of bacterial resistance. A. Pefloxacin B. Nalidixic Acid C. Ciprofloxacin D. Gatifloxacin
B. Nalidixic Acid
Prokinetic agent that act as selective 5HT4 agonists. A. Promethazine B. Belastin C. Mosapride D. Metoclopromide
C. Mosapride
DMARD are the primary treatment for rheumatoid arthritis. Identify the INCORRECT statement.
A. It can decrease joint damage
B. It can improve over all functional abilities
C. It has no effect on disease remission
D. It can produce improvement in symptoms
C. It has no effect on disease remission
Select the Dopamine receptor agonist A. Selegeline B. Carbegoline C. Tolcapone D. Benzatropine
D. Benzatropine
- The cardiac affect associated with Theophylline can be explained by
A. Antagonism of Beta-2 sympathetic receptor
B. Competitive non-selective inhibition of phosphodiesterase
C. Non-selective anatagonism of adenosine receptor
D. Agonism of muscarinic receptor
B. Competitive non-selective inhibition of phosphodiesterase
Belle is presently 18 weeks AOG, with urinary tract infection. Select the drug that can be prescribed to Belle. A. Gentamicin B. Chloramphenicol C. Doxycycline D. Ampicillin
D. Ampicillin
Kim Sia consulted on your clinic for second opinion. A previous doctor diagnosed her with multiple sexually transmitted diseases by the following infectious agents: Treponema, Chlamydia, and Neisseria. Which of the following antibiotics has activity against all three organisms? A. Penicillin G B. Doxycycline C. Gentamycin D. Ceftriaxone
B. Doxycycline
Rationale:
Pen g, ceftriaxone, gentamicin cannot be used in atypical organism such as Chlamydia.
One of the treatment goals for gastroparesis is to increase motility and resting tone within the gastrointestinal tract through antagonism of dopamine receptors using. A. Ranitidine B. Omeprazole C. Sucralfate D. Metoclopromide
D. Metoclopromide
Rationale:
Ranitidine- H2 receptor antagonist
Omeprazole- PPI
Sucralfate- Coats the stomach creating a barrier
Select the INCORRECT statement regarding complicated Urinary tract infection.
A. It requires more aggressive evaluation and treatment
B. It can be treated using a 3-day course of fluoroquinolone.
C. It is associated with occurrence of antibiotic resistance
D. It requires addressing the cause of complication
B. It can be treated using a 3-day course of fluoroquinolone.
Rationale:
Floruoquinolones usually around 10-14 days
