Panget Pharma PLE

Question 1

Thrombolytic therapy can be started after a few hours after the cerebral ischemic attack. Select the appropriate agent. 
A. Enoxaparin
B. Clopidogrel
C. Retaplase
D. Tirofibrin

Answer 1

C. Retaplase

Rationale:
A. Enoxaparin- LMWH (anti-thrombin)
B. Clopidogrel- ADP receptor antagonist (anti-coagulant)
D. Tirofibrin- GPIIb-IIIa receptor

Question 2

Which of the following is NOT seen in the use of Acetazolamide?
A. Prevents the secretion of H+ in the tubule.
B. Acidify the urine
C. Inhibits carbonic anhydrase
D. Promotes Na+ AND K+ excretion.

Answer 2

B. Acidify the urine

Rationale:
Alkanize bring by inhibiting secretion of H+ in tubules

Question 3

Kim Sia self medicated with prednisone for her allergy. You were alarmed because of the following side effects EXCEPT?
A. Hypocalcemia
B. Hyperglycemia
C. Hypertension
D. Better wound healing

Answer 3

D. Better wound healing

Rationale:
POOR wound healing

Question 4

Select the inhibitor of Dipeptidyl Peptidase-4 (DPP-4 inhibitor)
A. Pramlitide
B. Liraglutide
C. Glibenclamide
D. Sitagliptin

Answer 4

D. Sitagliptin

Rationale:
A. Pramlitide- Amylin analog
B. Liraglutide- GLP1 analogue
C. Glibenclamide- SU

Question 5

The use of spironolactone has been associated with which of the following side effects?
A.Hypermagnesemia
B Hyperkalemia
C. Hyperuricemia
D. Hypernatremia

Answer 5

B Hyperkalemia

Rationale:
All will be decreased ( Na, Ca, Mg) except for Potassium

Question 6

Which of the following is given for morphine addiction. It is usually started when the morphine withdrawal symptoms started.
A. Fentanyl
B. Hydrocodone
C. Tramadol
D. Buprenorphine

Answer 6

D. Buprenorphine

Rationale:

Opiods
A. Fentanyl
B. Hydrocodone
C. Tramadol

Question 7

Antibiotic when given concomitantly with Digoxin causes increase toxicity from Digoxin. This can be explained by.
A. Competes with digoxin binding site
B. Favors digoxin binding to cardiac cells
C. Destroying enteric bacteria that naturally inactivates Digoxin.
D. Impairs renal excretion of Digoxin.

Answer 7

C. Destroying enteric bacteria that naturally inactivates Digoxin.

Question 8

Which of the following is NOT given in patients with Esophageal Varices.
A. Ocreotide
B. Calcium channel blockers
C. Talipressin
D. Beta blockers

Answer 8

B. Calcium channel blockers

Rationale:
A. Ocreotide: Main Tx
C. Talipressin: Vasopressin derivative- Vasoconstriction
D. Beta blockers: Portal hypertension

Question 9

Linezolid has no activity against.
A. uncomplicated UTI
B. Nasocomial pneumonia
C. MRSA infections 
D. Intraabdominal infection by Enterococcus.

Answer 9

A. uncomplicated UTI

Rationale:
Sobra naman daw kaaga ibigay ang linezolid sa UTI dapat milder lang haha.

Question 10

Belle Nadora is complaining of increased facial hair (male pattern distribution). She was given Spirinolactone . This drug is effective by.
A. Being an anti-gonadotrophin
B. Inhibiting androgen synthesis
C. Inhibiting 5 alpha reductase
D. Being an androgen receptor antagonists

Answer 10

D. Being an androgen receptor antagonists

Rationale:
MOA of Spirinolactone is to competitively binds the Aldosterone receptor preventing the hormone to bind to its receptor.

Question 11

Effect of morphine at the mu receptor is responsible for the following EXCEPT?
A. Sedation
B. Respiratory Depression
C. Analgesia
D. Miosis
E. None of the above

Answer 11

E. None of the above

Question 12

Select the quinolone that has been associated with the development of bacterial resistance.
A. Pefloxacin
B. Nalidixic Acid
C. Ciprofloxacin
D. Gatifloxacin

Answer 12

B. Nalidixic Acid

Question 13

Prokinetic agent that act as selective 5HT4 agonists.
A. Promethazine
B. Belastin
C. Mosapride
D. Metoclopromide

Answer 13

C. Mosapride

Question 14

DMARD are the primary treatment for rheumatoid arthritis. Identify the INCORRECT statement.
A. It can decrease joint damage
B. It can improve over all functional abilities
C. It has no effect on disease remission
D. It can produce improvement in symptoms

Answer 14

C. It has no effect on disease remission

Question 15

Select the Dopamine receptor agonist
A. Selegeline
B. Carbegoline
C. Tolcapone
D. Benzatropine

Answer 15

D. Benzatropine

Question 16

16. The cardiac affect associated with Theophylline can be explained by
    A. Antagonism of Beta-2 sympathetic receptor
    B. Competitive non-selective inhibition of phosphodiesterase
    C. Non-selective anatagonism of adenosine receptor
    D. Agonism of muscarinic receptor

Answer 16

B. Competitive non-selective inhibition of phosphodiesterase

Question 17

Belle is presently 18 weeks AOG, with urinary tract infection. Select the drug that can be prescribed to Belle.
A. Gentamicin
B. Chloramphenicol
C. Doxycycline
D. Ampicillin

Answer 17

D. Ampicillin

Question 18

Kim Sia consulted on your clinic for second opinion. A previous doctor diagnosed her with multiple sexually transmitted diseases by the following infectious agents: Treponema, Chlamydia, and Neisseria. Which of the following antibiotics has activity against all three organisms?
A. Penicillin G
B. Doxycycline
C. Gentamycin
D. Ceftriaxone

Answer 18

B. Doxycycline

Rationale:
Pen g, ceftriaxone, gentamicin cannot be used in atypical organism such as Chlamydia.

Question 19

One of the treatment goals for gastroparesis is to increase motility and resting tone within the gastrointestinal tract through antagonism of dopamine receptors using.
A. Ranitidine
B. Omeprazole
C. Sucralfate
D. Metoclopromide

Answer 19

D. Metoclopromide

Rationale:
Ranitidine- H2 receptor antagonist
Omeprazole- PPI
Sucralfate- Coats the stomach creating a barrier

Question 20

Select the INCORRECT statement regarding complicated Urinary tract infection.
A. It requires more aggressive evaluation and treatment
B. It can be treated using a 3-day course of fluoroquinolone.
C. It is associated with occurrence of antibiotic resistance
D. It requires addressing the cause of complication

Answer 20

B. It can be treated using a 3-day course of fluoroquinolone.

Rationale:
Floruoquinolones usually around 10-14 days