Pancytopenia Flashcards
What characterizes aplastic anaemia?
Pancytopenia and a hypoplastic bone marrow.
What is the peak incidence age for acquired aplastic anaemia?
30 years old.
What are the features of aplastic anaemia?
Normochromic, normocytic anaemia; leukopenia with lymphocytes relatively spared; thrombocytopenia.
What may be the presenting feature of acute lymphoblastic or myeloid leukaemia?
Thrombocytopenia.
What conditions may develop in a minority of aplastic anaemia patients?
Paroxysmal nocturnal haemoglobinuria or myelodysplasia.
What are the idiopathic causes of aplastic anaemia?
Idiopathic causes.
What congenital conditions are associated with aplastic anaemia?
Fanconi anaemia and dyskeratosis congenita.
What drugs can cause aplastic anaemia?
Cytotoxics, chloramphenicol, sulphonamides, phenytoin, gold.
What toxins are known to cause aplastic anaemia?
Benzene.
What infections can lead to aplastic anaemia?
Parvovirus and hepatitis.
What environmental factor is a cause of aplastic anaemia?
Radiation.
What characterizes aplastic anaemia?
Pancytopenia and a hypoplastic bone marrow.
What is the peak incidence age for acquired aplastic anaemia?
30 years old.
What are the features of aplastic anaemia?
Normochromic, normocytic anaemia; leukopenia with lymphocytes relatively spared; thrombocytopenia.
What may be the presenting feature of acute lymphoblastic or myeloid leukaemia?
Thrombocytopenia.
What conditions may develop in a minority of aplastic anaemia patients?
Paroxysmal nocturnal haemoglobinuria or myelodysplasia.
What are the idiopathic causes of aplastic anaemia?
Idiopathic causes.
What congenital conditions are associated with aplastic anaemia?
Fanconi anaemia and dyskeratosis congenita.
What drugs can cause aplastic anaemia?
Cytotoxics, chloramphenicol, sulphonamides, phenytoin, gold.
What toxins are known to cause aplastic anaemia?
Benzene.
What infections can lead to aplastic anaemia?
Parvovirus and hepatitis.
What environmental factor is a cause of aplastic anaemia?
Radiation.
What is drug-induced pancytopaenia?
Pancytopaenia caused by various drugs.
What are some cytotoxic drugs that can cause pancytopaenia?
Cytotoxic drugs.
Which antibiotics are known to cause pancytopaenia?
Trimethoprim, chloramphenicol.
What anti-rheumatoid drugs can lead to pancytopaenia?
Gold, penicillamine.
What is a drug that causes both agranulocytosis and pancytopaenia?
Carbimazole.
Causes both agranulocytosis and pancytopaenia.
Which anti-epileptic drug can cause pancytopaenia?
Carbamazepine.
What sulphonylurea is associated with pancytopaenia?
Tolbutamide.
What is drug-induced pancytopaenia?
Pancytopaenia caused by various drugs.
What are some cytotoxic drugs that can cause pancytopaenia?
Cytotoxic drugs.
Which antibiotics are known to cause pancytopaenia?
Trimethoprim, chloramphenicol.
What anti-rheumatoid drugs can lead to pancytopaenia?
Gold, penicillamine.
What is a drug that causes both agranulocytosis and pancytopaenia?
Carbimazole.
Causes both agranulocytosis and pancytopaenia.
Which anti-epileptic drug can cause pancytopaenia?
Carbamazepine.
What sulphonylurea is associated with pancytopaenia?
Tolbutamide.
