pancreatitis Flashcards

1
Q

what questions do you ask when someone comes in

A

What is the diagnosis?
How sick is he?
What is the underlying cause?

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2
Q

definition of acute pancreatitis

A

an acute inflammatory process that leads to the necrosis of pancreatic parenchyma

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3
Q

signs of acute pancreatitis

A

severe abdominal pain, nausea, vomiting, diarrhoea, fever, and shock

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4
Q

signs of shock

A

high pulse

low BP

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5
Q

describe capillary refil time

A

blood flow back into hands

should be <2s

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6
Q

diagnostic approach

A
History
Examination
Tests:
SIMPLE BLOOD TESTS - Straight forward blood tests – everyone gets when come in 
COMPLEX BLOOD TEST
SIMPLE IMAGING
CROSS SECTIONAL IMAGING - CT
INVASIVE TEST

basics first = more differentials

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7
Q

where is anylase produced

A

pancreas

salivary glands

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8
Q

why would white cell count be raised

A

infection

severe inflammation

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9
Q

what is ALT

A

alanine transferase

marker of hepatocyte function

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10
Q

albumin test

A

if low - something going on

the lower it is the worse the issue is

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11
Q

what is ALP

A

alkaline phosphatase

lines sinusoids

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12
Q

CT with pancreatitis

A

Inflammation tracking to retroperitoneal spaces and umbilicus

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13
Q

Magnetic resonance cholangiopancreatography

A

look at blockage in bile ducts – consider if no obvious cause

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14
Q

describe ERCP

A

Endoscopic retrograde cholangiopancreatography
cannular all the way down
wire into bile duct through ampulla of Vater - inject dye and take X ray

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15
Q

scoring systems for a pancreatitis

A

Ranson’s – alcoholic cause
APACHE II – anaesthesia for surgery
SIRS – inflammation

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16
Q

describe SIRS scoring

A

temp - >38 <36
HR >90beats/min
resp rate >20 breaths/min or PaCO2 <32mmHg
WBC >12000cells/mL or <4000cells/mL - Low white cell count – first sign of inf – all taken to one point before bone marrow can make more

17
Q

Ranson score

A
age >55
wbc >16000
blood glucose >11.1mmol/L 
LDH >350U/L 
aspartate amino transferase >250UU/L 
haematocrit fall byb >10% 
blood urea nitrogen -  Increase by ≥1.8 mmol/L despite fluids
serum ca <2mmol?l 
pO2 <60mmHg 
base deficit >4 
fluid sequestration >6L - oedema
18
Q

risk factor for a pancreatitis

A
Necrosis vs non necrosis
Organ failure
Age
Co morbidities - Resp failre, malabsorption, gut failure, heart failure 
Alcohol
19
Q

aetology of a pancreatitis

A

Gallstones
Ethanol
Trauma

Steroids
Mumps
Autoimmune - getting more common
Scorpion bite
Hyperlipidaemia/ Hypercalcaemia/Hypothermia
ERCP - 2% risk
Drugs (azathioprine, valproate)- not frequent but recognisable

20
Q

systemic complications of a pancreatitis

A

Hypovolaemia - fluid gone elsewhere
Hypoxia - fluid affectring lung
Hypocalcaemia
Hyperglycaemia - decreased insulin release
DIC - all clotting controllers go to gut = uncontrollable bleeding
Multiple organ failure

21
Q

localised complications of a pancreatitis

A

Pancreatic necrosis- dies
Fluid collections – mature into pseuduocysts - pressure defects - pain and discomfort - vomiting and difficulty swallowing
Splenic vein thrombosis/pseudoaneurysm- systemic portal hypertension
Chronic Pancreatitis

22
Q

treatment of a pancreatitis

A

Supportive:
Fluids
Painkillers
Nutrition - feeding into gut better then veins if not very unwell
Organ Support
Management of complications
Support bp – ionotropes – improve venous return to heart

23
Q

definition of chronic pancreatitis

A

progressive fibroinflammatory process of pancras - permenant structural damage - impairment of exocrine/.endocrine function

24
Q

complication of c pancreatitis

A

Malabsorption -Loss of 90% exocrine function - Fat soluble vitamin malabsorption

25
Q

symptoms of c pancreatitis

A

severe weight loss, ab pain, watery diarrhoea

26
Q

investigation of chronic pancreatitis

A

Plain Xray - calcification in pancreas, V ueful sign, confirmed on Ct - dilation of pancreatic ducts
CT scan
Faecal elastase- nzymes released by panc - marker for rest - measured in faecal sample - if low correct

27
Q

management of chronic pancreatitis

A

Stop alcohol and smoking
Small meals with low fat - it affects gastric emptying
PPI – reduce acidity in stomach – so doesn’t reduce the effect of enxymes
and pancreatic supplements
Analgesia - reduce pain