Pancreatitis Flashcards
1
Q
Acute pancreatitis - Pathogenesis
A
- When protective mechanisms overcome inappropriate activation of enzymes within pancreas
- Resulting in “auto-digestion” of pancreatic cells and inflammatory reaction (interleukins, TNF, PAF)
- Acinar cells damaged and leak activated digestive enzymes into the intercellular space => fat necrosis => retroperitoneal/systemic inflammation
2
Q
Mechanisms of Acute Pancreatitis
A
3
Q
Epidemiology of Acute Pancreatitis
A
4
Q
Etiology of Acute Pancreatitis: common causes
A
5
Q
Etiology of Acute Pancreatitis: rare causes
A
6
Q
Clinical Manifestations: Local of Acute Pancreatitis
A
6
Q
Clinical Manifestations: Systemic of Acute Pancreatitis
A
7
Q
Diagnosis of acute pancreatitis (2 out of 3)
A
8
Q
Assessment of Severity: Acute Pancreatitis
A
- Ranson
- Apache II
- Balthazar CTSI
- Glasgow-Imrie Criteria
- Hong Kong Index
- Atlanta
- BISAP
9
Q
Management of Acute Pancreatitis: Days 1-14
A
10
Q
Management of Acute Pancreatitis: Days 15-?
A
11
Q
Treatment of acute pancreatitis
A
- Assessment for gallstone etiology
- Abdominal sonogram (CBD > 6 mm)
- ALT > 3x above normal
- GGT > 7x above normal
- Total bilirubin > 3.0
- Cholangitis
- Known gallstones (cholelithiasis)
12
Q
Mechanism of Gallstone Pancreatitis
A
13
Q
Chronic Pancreatitis Definition
A
14
Q
Chronic Pancreatitis: Patterns of Pain
A