Pancreatitis Flashcards

1
Q

Acute pancreatitis - Pathogenesis

A
  • When protective mechanisms overcome inappropriate activation of enzymes within pancreas
  • Resulting in “auto-digestion” of pancreatic cells and inflammatory reaction (interleukins, TNF, PAF)
  • Acinar cells damaged and leak activated digestive enzymes into the intercellular space => fat necrosis => retroperitoneal/systemic inflammation
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2
Q

Mechanisms of Acute Pancreatitis

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3
Q

Epidemiology of Acute Pancreatitis

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4
Q

Etiology of Acute Pancreatitis: common causes

A
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5
Q

Etiology of Acute Pancreatitis: rare causes

A
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6
Q

Clinical Manifestations: Local of Acute Pancreatitis

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6
Q

Clinical Manifestations: Systemic of Acute Pancreatitis

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7
Q

Diagnosis of acute pancreatitis 
 (2 out of 3)

A
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8
Q

Assessment of Severity: Acute Pancreatitis

A
  • Ranson
  • Apache II
  • Balthazar CTSI
  • Glasgow-Imrie Criteria
  • Hong Kong Index
  • Atlanta
  • BISAP
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9
Q

Management of Acute Pancreatitis: Days 1-14

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10
Q

Management of Acute Pancreatitis: Days 15-?

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11
Q

Treatment of acute pancreatitis

A
  • Assessment for gallstone etiology
  • Abdominal sonogram (CBD > 6 mm)
  • ALT > 3x above normal
  • GGT > 7x above normal
  • Total bilirubin > 3.0
  • Cholangitis
  • Known gallstones (cholelithiasis)
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12
Q

Mechanism of Gallstone Pancreatitis

A
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13
Q

Chronic Pancreatitis Definition

A
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14
Q

Chronic Pancreatitis: Patterns of Pain

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15
Q

Chronic Pancreatitis: Clinical Presentation

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16
Q

Chronic Pancreatitis: Genetic

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17
Q

Chronic Pancreatitis: Idiopathic

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18
Q

Chronic Pancreatitis: Diagnosis

Laboratory Tests: Serum and Stool

A
19
Q

Chronic Pancreatitis: Diagnosis

Laboratory Tests: Secretin Stimulation test

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20
Q

Pathophysiology of Pain in CP

1 Mechanical – ‘Plumbing Problems’

A
21
Q

Pathophysiology of Pain in CP

2 Neurobiologic – ‘wiring problems’

A
22
Q

Pathophysiology of Pain in CP
 3 Complications

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23
Q

Pathophysiology of Pain in CP
 3 Complications

A
24
Q

Pathophysiology of Pain in CP
 4 Adverse Effects of Treatment

A

Opioid-induced bowel dysmotility

Bacterial overgrowth

Endoscopic complications

Surgical complications

25
Q

Endotherapy in Chronic Pancreatitis

A
26
Q

Complications of Pancreatitis

A
  • Pancreatic Fluid Collections
    • Pancreatic duct disruption
    • Pseudocyst
    • Walled-Off Necrosis (WON)
27
Q

Drainage

A
28
Q

____ guided drainage of pseudocysts using FCSEMS is safe and effective.

A

EUS guided drainage of pseudocysts using FCSEMS is safe and effective.

29
Q

Drainage of PP using FCSEMS results in

A
  • Better clinical outcomes
  • Lower adverse events when compared to those drained via DP stents