Pancreatic Neoplasms Flashcards
What are the risk factors for pancreatic adenocarcinoma?
>60 Smoking Alcohol Diabetes Chronic pancreatitis Genetics
What affects the presentation of pancreatic adenocarcinoma?
Location of tumour
Both can present as acute pancreatitis/diabetes
How do carcinomas of the pancreatic head present?
Presente earlier w/ painless jaundice Signs related to obstructive jaundice -Courvoisier's sign -palpable abdo mass -hepatosplenomegaly -ascites
How do carcinomas of the body/tail of the pancreas present?
Present later w/ dull abdominal pain radiating to back (relieved by sitting forwards)
Non specific sx common
What are the common pancreatic neoplasms?
Ductal adenocarcinomas
- 60% in head
- 25% in body
- 15% in tail
Describe islet cell tumours
<2% pancreatic neoplasms
Sx. relate to secreted hormone
What are the five types of islet cell tumour?
Insulinoma Glucagonoma Gastrinoma Somatostatinoma VIPoma
What is the prognosis of pancreatic carcinomas?
Mean survival <6/12
5 yr survival <2%
-rises to 5-15% following Whippet’s
What pancreatic carcinomas have a better prognosis?
Ampullary/islet cell tumours (present early)
How do Insulinomas present?
Symptomatic hypoglycaemic events
Gross weight gain
90% benign
How do Glucagonomas present?
Often asymptoamtic
Secondary DM
How do Gastrinomas present?
Zollinger-Ellison syndrome
- oesophagitis
- GI ulcers
- diarrhoea
How do Somatostatinomas present?
DM
Achlorrhydria
Gallstones
How do VIPomas present?
Vasoactive intestinal peptide release causes profound diarrhoea
What is Trousseau’s syndrome?
Thrombosis of superficial/deep leg veins (thrombophlebitis migrans) related to pancreatic carcinoma