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GI Pharm > Pancreatic Meds > Flashcards

Pancreatic Meds Flashcards

1
Q

PANCRELIPASE (Viokase) Class

A

Pancreatic enzymes

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2
Q

PANCRELIPASE (Viokase) Indication

A

chronic pancreatitis

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3
Q

PANCRELIPASE (Viokase) MOA

A

supplemental enzymes (lipase, amylase, protease)

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4
Q

What’s the dosing of PANCRELIPASE (Viokase)?

A

~30,000units/meal

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5
Q

What allergy do we need to consider when giving PANCRELIPASE (Viokase)?

A

Pork!

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6
Q

MEPERIDINE (Demerol) Class

A

opioid analgesic (synthetic)

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7
Q

MEPERIDINE (Demerol) Indication

A

short-term use peri-op and acute pancreatitis (less sphincter of Oddi spasm?)

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8
Q

MEPERIDINE (Demerol) MOA

A

binds to mu opioid receptors in CNS and inhibits ascending pain pathways

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9
Q

RANITIDINE (Zantac) Class

A

H2 receptor antagonist

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10
Q

RANITIDINE (Zantac) Indication

A

peptic ulcer disease, GERD

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11
Q

RANITIDINE (Zantac) MOA

A

competitive inhibition of H2-receptors of gastric parietal cells reduce basal and stimulated acid production

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12
Q

Is Meperidine a good choice for an elderly patient?

A

NO! It can cause seizures!! BLACK BOX WARNING

Can only be used acutely

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13
Q

What type of symptoms do we typically prescribe ranitidine for?

A

GERD with nocturnal symptoms

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14
Q

What is the best time to take ranitidine? Why?

A

between 6PM

Because the highest production of acid occurs at 7PM

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15
Q

Where do PPI’s work?

A

On the parietal cells, binding to H, K+ATPase, inactivating the enzyme.

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16
Q

How do we administer a PPI?

A

On an empty stomach

17
Q

How long does a PPI work for?

A

24 hours

18
Q

How long does it take to see full effects of a PPI?

A

3-4 days; can also take 3-4 days to come off the medication

19
Q

OMEPRAZOLE (Prilosec) Class

A

proton pump inhibitor (PPI)

20
Q

OMEPRAZOLE (Prilosec) Indicaiton

A

peptic ulcer disease, GERD; prevention of NSAID ulcers; stress ulcer prophylaxis in critically ill

21
Q

OMEPRAZOLE (Prilosec) MOA

A

inhibits basal and stimulated parietal cell proton pump acid secretion

22
Q

What medication can you not take with Omeprazole (prilosec)?

A

Clopidogrel!

23
Q

If a patient is on clopidogrel and has GERD, what other PPI can you prescribe?

A

PANTOPRAZOLE (Protonix)

24
Q

PANTOPRAZOLE (Protonix) Indicaitons

A

PUD, GERD; prevention of NSAID ulcers; stress ulcer prophylaxis in critically ill

25
Q

PANTOPRAZOLE (Protonix) MOA

A

inhibits basal and stimulated parietal cell proton pump acid secretion

26
Q

So, can we stop a PPI abruptly?

A

No

27
Q

How long before a meal should we tell our patients to take their PPI?

A

0.5-1 hour before

28
Q

What antibiotic can we use to treat resistant gram negative psudeomonas and enterobacter infections?

A

IMIPENEM-CILASTIN (Primaxim)

29
Q

IMIPENEM-CILASTIN (Primaxim) indication

A

intra-abdominal infections, liver abscess, lower respiratory tract and GYN organ infections

30
Q

IMIPENEM-CILASTIN (Primaxim) MOA

A

inhibits bacterial cell wall synthesis with lyses of bacterial cells

31
Q

CIPROFLOXACIN (Cipro) Class

A

Fluoroquinolone

32
Q

CIPROFLOXACIN (Cipro) Indications

A

diverticulitis, mild; traveler’s diarrhea; UTIs, anthrax (inhalation, cutaneous, GI), chlamydial infections, cholera, salmonosis, shigella

33
Q

What must we always remember is a S/E of cipro?

A

tendon rupture!

And QT prolongation, rash, and photosensativity

34
Q

METRONIDAZOLE (Flagyl) indicaiton

A

anaerobic bacterial and protozoal infections: diverticulitis; c diff colitis; vaginitis; brain abscess; rosacea, amebiasis, giardiasis, trichomonas

35
Q

METRONIDAZOLE (Flagyl) MOA

A

disrupts DNA structure inhibiting protein synthesis producing cell death

36
Q

VANCOMYCIN (Vancocin) indicaiton

A

PO treatment of staph enterocolitis or antibiotic-associated pseudomonas (c. diff) colitis: IV MRSA, HAP meningitis, pre-op Px infective endocarditis

37
Q

VANCOMYCIN (Vancocin) Class

A

glycopeptide antibiotic

38
Q

VANCOMYCIN (Vancocin) MOA

A

inhibits bacterial cell wall synthesis by blocking polypeptide polymerization

GI Pharm (5 decks)

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