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Enzymes > Pancreatic Enzymes > Flashcards

Pancreatic Enzymes Flashcards

1
Q

What are the pancreatic enzymes?

A

Amylase and lipase

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2
Q

To what class of enzymes does amylase belong?

A

Hydrolase

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3
Q

It catalyzes the breakdown of starch and glycogen

A

Amylase

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4
Q

2 components of starch

A

Amylose and amylopectin

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5
Q

It is a branched chain polysaccharide with alpha, 1-6 linkages at branching points

A

Amylopectin

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6
Q

Long unbranched chain of glucose molecules linked by alpha, 1-4 glycosidic bonds

A

Amylose

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7
Q

Glycogen is similar to what component of starch?

A

Amylopectin

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8
Q

Alpha-AMY attacks only the alpha, 1-4 glycosidic bonds producing…

A

Glucose, maltose and dextrin

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9
Q

Intermediate chain which contains alpha, 1-6 linkages

A

Dextrin

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10
Q

Amylase requires these ions for activation

A

Calcium and chloride

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11
Q

Major tissue sources of amylase

A

Salivary glands and acinar cells (pancreas)

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12
Q

It is the smallest enzyme

A

Amylase

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13
Q

Which amylase (salivary or pancreatic) is of short duration and inhibited by the acidity of gastric contents?

A

Salivary amylase

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14
Q

Which amylase (pancreatic or salivary) performs the major digestive action of starches?

A

Pancreatic amylase

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15
Q

Urine and serum AMY is significant in the diagnosis of what disease

A

Acute pancreatitis

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16
Q

Condition which can occur in neoplastic diseases with elevated results as high as 50 times the ULN

A

Hyperamylasemia

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17
Q

Condition that results when amylase molecule combines with immunoglobulins

A

Macroamylasemia

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18
Q

Isoenzymes of amylase

A

P and S isoamylase

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19
Q

Isoamylase that migrate most quickly

A

S isoamylase

20
Q

Most commonly observed fraction of isoamylase

A

P2, S1 and S2

21
Q

What isoamylase significantly increases in acute pancreatitis? And what is the predominant isoenzyme involved?

A

P isoamylase, P3

22
Q

Methods of determination of amylase activity

A

Amyloclastic method, saccharogenic, chromogenic, continuous monitoring

23
Q

Measures the disappearance of starch

A

Amyloclastic

24
Q

Measures the appearance of product

A

Saccharogenic

25
Q

Measures the increasing color from production of product coupled with a chromogenic dye

A

Chromogenic

26
Q

Coupling of several enzyme systems to monitor amylase activity

A

Continuous monitoring method

27
Q

Classic reference method for amylase

A

Saccharogenic

28
Q

It is an expression of the number of milligrams of glucose released in 30 minutes at 37 degree celsius under specific assay conditions

A

Somogyi units

29
Q

Change in absorbance of NAD is measured at? (Continuous monitoring method)

A

340 nm

30
Q

Salivary AMY is inhibited by

A

Wheat germ lectin

31
Q

True or false

Plasma triglycerides inhibit or suppress serum LPS activity

A

False

Should be Amylase

32
Q

True or false

Morphine and other opiates falsely decrease serum AMY

A

True

33
Q

Conversion factor between somogyi units and IUs

A

1.85

34
Q

It hydrolyzes ester linkages of fats to produce alcohol and fatty acids

A

Lipase

35
Q

Intermediate in the partial hydrolysis of dietary triglycerides

A

2-monoglyceride

36
Q

True or false
The substrate must be an emulsion for the activity of pancreatic lipase, specific for FA residues at position 1 and 3, to occur?

A

True

37
Q

Reaction rate of the pancreatic lipase is accelerated by

A

Colipase and bile salt

38
Q

Most clinically specific and sensitive lipase isoenzyme

A

L2

39
Q

Which pancreatic eznyme is more specific for pancreatic disorders?

A

Lipase

40
Q

2 Method of determination of lipase using titrimetric method ?

A

Cherry crandall and tietz

41
Q

Substrate for cherry crandall

A

Olive oil (50%)

42
Q

Substrate for tietz that is a pure form of triglyceride

A

Triolein

43
Q

Method for lipase determination that is more rapid and simpler

A

Turbidimetric method

44
Q

Salivary amylase is also known as

A

Ptyalin

45
Q

Pancreatic amylase is also known as

A

Amylopsin

46
Q

Lipase remains in circulation for how many days

A

8 days

47
Q

End color of cherry crandall? Tietz?

A

Cherry crandall - pink

Tietz - blue

Enzymes (3 decks)

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