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U6 Physiology > Pancreatic/ Biliary Function - IN > Flashcards

Pancreatic/ Biliary Function - IN Flashcards

1. Doses n Mimosas 2. Champagne n Cocaine

1
Q

What are the pancreatic endocrine secretions

A

glucagon, insulin, somatostatin

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2
Q

what are the pancreatic exocrine secretions

A

secretin, VIP, CCK, ACh, gastrin

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3
Q

what is the main purpose of pancreatic juice

A

bicarbonate secretion to neutralize that WACK STOMACH ACID GET OUTTA HERE

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4
Q

what secretions increase cAMP

A

secretin, VIP

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5
Q

what secretions increase intracellular Ca2+

A

CCK, ACh, Gastrin

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6
Q

do secretin and CCK act synergistically or antagonistically

A

synergy.

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7
Q

what is the danger of excess VIP

A

can cause VIPomas (pancreatic tumor type) and gross diarrhea

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8
Q

what type of cells secrete bicarbonate

A

epithelial duct cells, centro-acinar cells

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9
Q

how is bicarbonate secreted

A

CO2 diffuses from blood through cell, across basolateral membrane, interacts with carbonic anhydrase to make H+, HCO3-

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10
Q

what happens to venous blood during secretion

A

it is acidified -> helps negate alkaline tide produced in stomach

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11
Q

does Secretin stimulate or inhibit pancreatic aqueous secretion

A

stimulate - activates CFTR Cl- channel -> replenishes luminal Cl- needed for Cl-/HCO3- exchange

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12
Q

does CCK stimulate or inhibit pancreatic aqueous secretion

A

stimulate - primes Na/K ATPase by increasing intracellular Ca2+

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13
Q

What cells release Secretin

A

S cells - duodenal mucosa

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14
Q

What is “Nature’s Antacid” (hint: not bicarbonate)

A

Secretin - inhibits gastric secretions and release of Gastrin

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15
Q

What cells release CCK

A

I cells - in response to fatty acids or AA in duodenum, slows gastric emptying

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16
Q

what role does Vagus nerve have in digestion

A

none. TID.

just kidding - acts on gallbladder to contract and sphincter of Oddi to relax and release bile - much like CCK

17
Q

What is the major route of cholesterol and steroid hormone breakdown

A

hepatic production of bile acids

18
Q

what is the rate limiting step in bile synthesis

A

cholesterol-7-a-hydroxylase addition of OH group on C7 of cholesterol

19
Q

how is net luminal acid secretion maintained in the gallbladder

A

apical Na/H exchange is slightly faster than apical Cl/HCO3 exchange

20
Q

what are gallstones composed of

A

15% lecithin, 80% bile salts, 5% cholesterol

21
Q

how are gallstones formed

A
  1. supersaturation of cholesterol in the liver, 2. nucleation and precipitation, 3. growth of microstones into macrostones
22
Q

what is cholecystitis

A

inflammation of gallbladder most commonly caused by blockage of cystic duct by a gallstone

U6 Physiology (13 decks)

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