Pancreas I Flashcards
The exocrine pancreas is composed of ?
What does it secrete?
Where do these secretions head to ?
These digestive enzyme need to be activated

The endocrine pancreas is composed of what type of cells?
What do these cells secrete?
Composed of the islets of Langerhans that
secrete:
- insulin by β cells
- glucagon by α cells
- somatostatin by δ cells
- PP cells secrete pancreatic polypeptide
Excrine pancreas diagrams

Diabetes Mellitus can be defined as a group of metabolic disorders sharing the commone feature of hyperglycemia…Hypergycemia in diabetes is caused by?
- defects in insulin secretion
- insulin action
- or, most commonly, both
Chronic hypergycemia and associated metabolic dysregulation might cause?
secondary damage in multiple organ systems, especially the kidneys, eyes,
nerves and blood vessels
After a meal, Insulin in normal subjects does what two things in normal people?
- It decreases liver glucose production by decreasing both glycogenolysis and gluconeogenesis
-
It increases glucose uptake by skeletal muscle and adipose tissue by
translocating glucose transporters
What counter-regulatory hormones increases within the earliest stages of hypoglycemia ?
What type of natual behaviors occur during a hypoglycemic state?
What happens to the plasma glucose concetration levels?
Relation between insulin and glucagon:
- In the earliest stages (within minutes):
- decreased insulin increased glucagon
Behavior defenses:
- The initial symptoms of sweating, anxiety, palpitations, hunger and tremor
- plasma glucose concentration falls below 55 mg/dL

There is a direct relationship between overnight blood glucose and the cause of the following morning hyperglycemia glucose level… What are they?
the cause of morning hyper glycemia is …nocturnal growth hormone secretion and hypoinsulinemia
How can exercise affect someone with insulin-deficient diabetes?
increases glucose utilization
by muscle can cause
hypoglycemia in patients with
insulin-deficient diabetes
Hypoglycemia-Associated Autonomic Failure (HAAF) in Diabetes is defined as ?
What is the Hypoglycemia-Associated Autonomic Failure (HAAF) mechanism?
- the clinical syndromes of defective glucose counter-regulation and hypoglycemia unawareness
- hypoglycemia, even if asymptomatic, causes a vicious cycle of recurrent hypoglycemia
HAAF mechanism:
-reducing the sympathoadrenal response to subsequent hypoglycemia due to:
- changes in hypothalamic functions
- increase in cortisol
What is the most important stimulus for insulin synthesis and release?
glucose itself
How does glucose get inside the cells?
- Glucose enters beta cells via the glucose transporter, GLUT2, which causes the release of insulin into the blood stream to bind to insulin receptors
- Insulin stimulates glucose uptake by skeletal muscle and fat by GLUT-4
- GLUT-2 acts on?
- GLUT-3 acts on?
- GLUT-4 acts on?
- GLUT-2 acts on– Beta cells, liver cells
- GLUT-3 acts on– All tissues, central nervous system
- GLUT-4 acts on?– Skeletal muscle, fat cells
Effect of insulin on metabolism of:
- Glucose?
- Fat: ?
- Protein: ?
- Glucose
- Prevens liver from forming new glucose - inhibits gluconeogenesis
- Increases uptake by skeletal/fat cells
- Prevens liver from forming new glucose - inhibits gluconeogenesis
- Fat: decrease lipolysis
- Causes storage of triglycerides in fat cells
- decrease lipolysis means less fatty acids go to liver leads to decrease production of glucose
- Causes storage of triglycerides in fat cells
- Protein: inhibits breakdown
- decreases catabolism
Effects of insulin on:
- Adipose tissue
- Straited muscle
- Liver

Where does glycated hemoglobin come from?
What is the Clinical test to estimate blood glucose control?
What does this test reflect ?
- measurement of glycated hemoglobin (also called A1C, hemoglobin A1C, glycohemoglobin, or HbA1C)
- Goal is less than or equal to 7% blood glucose
- A1C reflects mean blood glucose over
the entire 120-day lifespan of the red blood cell, but it correlates best with mean blood glucose over the previous 8 to 12 weeks

Describe type I and type II diabetes?
- Type I
- an autoimmune disease characterized by pancreatic β cell
destructionand anabsolute deficiency of insulin- Islet destruction by endogenous β-cell antigens
- an autoimmune disease characterized by pancreatic β cell
- Type II
- caused by a combination of peripheral resistance to insulin action and an inadequate secretory response by the pancreatic β cells (“relative
insulin deficiency”)
- caused by a combination of peripheral resistance to insulin action and an inadequate secretory response by the pancreatic β cells (“relative
What are the etiologies of type I and type II

You are genetically susceptibility to aquiring type I diabetes who are heterozygous for high-susceptibility genes in what region?
- HLA region
- group of genes on chromosome six that encode for the MHC
- protein that is extemely important for helping the immune system recognize foreign molecules along with maintaing self tolerance
- group of genes on chromosome six that encode for the MHC
What is the immunologic response that leads to the islet cell destruction?
- The Beta cell antigens binds to MHC Class II this leads to T-Cell activation. These T-cells don’t recognize our own bodys own cells and caus autoimmune injury to the pancreatic beta cells →less insulin →less glucose entering cells so blood glucose increases
- (These rogue T-cells are knwon as Islet cell autoantibodies (ICAs))
- Costimulatory proteins further increase T Cell activation
How do “people” measure the risk of type I diabetes?
- It is asses in the amount of islet autoantibodies
- The presence of two or more of these islet autoantibodies leads to increase risk of type I diabetes
- Insulin
- Glutamic acid decarboxylase (GAD)
- Insulinoma associated antigens 2 (alpha and beta)
- ZnT8 (zinc transporter)
Clinically evident type 1 diabetes does not occur until….?
Clinically evident type 1
diabetes does not occur until
there has been a much greater
loss of functioning beta cell
mass = >50% destruction
When does type I diabetes appear if there are genetic markers for it versus immune markers?
• Genetic markers: present from birth
• Immune markers: first appear at the time of the
environmental triggering events
Is Diabetic ketoacidosis (DKA) & hyperosmolar hyperglycemic state (HHS) related to type I or II ?
DKA - type I
HHS-type II





