PANCREAS ANAPHY and Acute Pancreatitis Flashcards
What is the primary endocrine function of the pancreas?
a. Producing insulin
b. Completing starch digestion
c. Neutralizing acidic chyme
d. Breaking down nucleic acids
Answer:
a. Producing insulin
Rationale:
The pancreas has both endocrine and exocrine functions. It produces insulin (and glucagon) as part of its endocrine function to regulate blood glucose levels.
The pancreas produces
a) sodium bicarbonate
b) peptidases and proteinases
c) lipases and amylase
d) nucleases
e) all of the above
Answer: e) all of the above
Which enzyme is responsible for promoting fat breakdown and absorption?
a. Pancreatic amylase
b. Pancreatic lipase
c. Trypsin/chymotrypsin
d. Nucleases
Answer:
b. Pancreatic lipase
Rationale:
Pancreatic lipase is responsible for promoting the breakdown and absorption of fats.
What is the primary role of trypsin/chymotrypsin in pancreatic enzyme function?
a. Completing starch digestion
b. Promoting fat breakdown
c. Breaking down nucleic acids
d. Protein digestion
Answer:
d. Protein digestion
Rationale:
Trypsin/chymotrypsin is responsible for half of all protein digestion in the pancreatic enzyme function.
Which clinical manifestation is associated with acute pancreatitis and characterized by pain in the left upper quadrant 3-4 hours after the ingestion of alcohol and fatty acids?
a. Periumbilical ecchymosis (Cullen’s Sign)
b. Hemorrhage
c. Bruising in the stomach
d. Flank ecchymosis (Grey Turner’s Sign)
Answer:
a. Periumbilical ecchymosis (Cullen’s Sign)
Rationale:
Pain in the left upper quadrant 3-4 hours after the ingestion of alcohol and fatty acids is associated with acute pancreatitis and is a symptom of periumbilical ecchymosis (Cullen’s Sign).
What is the significance of Grey Turner’s Sign in acute pancreatitis?
a. Indicates severe pancreatitis
b. Suggests gallbladder inflammation
c. Confirms autoimmune pancreatitis
d. Predicts thrombocytopenia
Answer:
a. Indicates severe pancreatitis
Rationale:
Grey Turner’s Sign, manifested by flank ecchymosis, indicates severe pancreatitis and possible complications like hemorrhage or necrosis.
What is the primary role of trypsin and chymotrypsin in the pancreas?
a. Initiating fat digestion
b. Breaking down nucleic acids
c. Enhancing protein synthesis
d. Facilitating starch digestion
Answer:
c. Enhancing protein synthesis
Rationale:
Trypsin and chymotrypsin are responsible for HALF OF ALL THE PROTEIN DIGESTION, playing a crucial role in enhancing protein synthesi
Which pancreatic enzyme completes starch digestion?
a. Pancreatic amylase
b. Pancreatic lipase
c. Trypsin/chymotrypsin
d. Nucleases
Answer:
a. Pancreatic amylase
Rationale:
Pancreatic amylase is responsible for completing starch digestion
What does the sphincter of Oddi being inflamed contribute to in acute pancreatitis?
a. Increased fat absorption
b. Auto-digestion of the pancreas
c. Enhanced protein digestion
d. Accelerated starch digestion
Answer:
b. Auto-digestion of the pancreas
Rationale:
Inflamed sphincter of Oddi contributes to the inability to remove pancreatic juices, leading to auto-digestion of the pancreas in acute pancreatitis.
Which enzyme is involved in breaking down nucleic acids?
a. Pancreatic amylase
b. Pancreatic lipase
c. Trypsin/chymotrypsin
d. Nucleases
Answer:
d. Nucleases
Rationale:
Nucleases are responsible for breaking down nucleic acids.
What clinical finding suggests the seepage of blood-stained exudates from the pancreas in acute pancreatitis?
a. Hemorrhage
b. Periumbilical ecchymosis (Cullen’s Sign)
c. Bruising in the stomach
d. Flank ecchymosis (Grey Turner’s Sign)
Answer:
d. Flank ecchymosis (Grey Turner’s Sign)
Rationale:
Flank ecchymosis (Grey Turner’s Sign) suggests the seepage of blood-stained exudates from the pancreas and indicates severe pancreatitis.
Why is it important for pancreatic enzymes to be secreted into the duodenum in an alkaline fluid?
a. To create an optimal environment for enzymatic activity
b. To neutralize acidic chyme from the stomach
c. To accelerate digestion of fats
d. To prevent auto-digestion of the pancreas
Answer:
b. To neutralize acidic chyme from the stomach
Rationale:
Pancreatic enzymes are secreted in an alkaline fluid to neutralize the acidic chyme from the stomach, creating an optimal environment for enzymatic activity.
What is the primary function of the exocrine portion of the pancreas, specifically carried out by the acini cells?
a. Production of insulin
b. Synthesis of gastric acids
c. Secretion of alkaline pancreatic juice
d. Storage of bile
Answer:
c. Secretion of alkaline pancreatic juice
Rationale:
The exocrine portion of the pancreas, through acini cells, secretes alkaline pancreatic juice that contains various enzymes. This juice helps neutralize acidic chyme from the stomach and provides an optimal environment for enzymatic activity in the small intestine during digestion.
How are pancreatic enzymes secreted into the duodenum?
a. In an acidic fluid
b. In a basic fluid
c. In an alkaline fluid
d. In a neutral fluid
Answer:
c. In an alkaline fluid
Rationale:
Pancreatic enzymes are secreted into the duodenum in an alkaline fluid, which neutralizes the acidic chyme coming from the stomach, creating an optimal environment for enzymatic activity.
What is the primary function of the Ampulla of Vater?
a. Storage of bile
b. Synthesis of pancreatic juice
c. Mixing of gastric acids
d. Meeting point for common bile duct and pancreatic duct
Answer:
d. Meeting point for common bile duct and pancreatic duct
Rationale:
The Ampulla of Vater is a small reservoir where the common bile duct and pancreatic duct meet. Its primary function is to collect bile from the liver and pancreatic juice from the pancreas before releasing them into the duodenum for digestion.
