PANCREAS

Question 1

Acinar and ductal cells secrete this trypsin inhibitor, which further limits intrapancreatic trypsin activity

Answer 1

Serine protease inhibitor kazal type 1 (SPINK1)

Question 2

These are present in 35% to 60% if acute pancreatitis cases

Answer 2

Gallstones

Question 3

Epithelial anion channel. Loss of function alter fluid pressure and limit bicarbonate secretion, leading to inspissation of secreted fluids and duct obstruction

Answer 3

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR 7q31)

Question 4

Cationic trypsin. Gain-of-function mutations prevent self-inactivation of trypsin

Answer 4

Serine Protease I (Trypsinogen 1) - PRSS1 (7q34)

Question 5

Inhibitory trypsin. Mutations causes loss of function, increasing trypsin activity

Answer 5

Serine Peptidase Inhibitor, Kazal type 1 (SPINK1 5q32)

Question 6

Membrane bound receptor that senses extracellular calcium levels and controls luminal calcium levels. Mutations may alter calcium concentrations and activate trypsin

Answer 6

Calcium sensing receptor (CASR 3q13)

Question 7

Degrade trypsin, protects the pancreas f4om trypsin-rekated injury

Answer 7

Chymotrypsin (caldecrin) - CTR 1p36

Question 8

Exopeptidase involved in regulating zymogen activation

Answer 8

Carboxypeptidase A1 (CPA1 7q32)

Question 9

To factors that have been proposed to contribute to alcohol-induced pancreatitis

Answer 9

1. Duct Obstruction
2. Acinar cell damage