PANCE review: MOA

Question 1

Finasteride/dutasteride

Answer 1

5-alpha-reductase inhibitor: prevents the conversion of testosterone to DHT to treat erectile dysfunction

Question 2

Doxazosin/terazosin/tamsulosin

Answer 2

Alpha-adrenergic inhibitors: treat erectile dysfunction

Question 3

Clopidogrel

Answer 3

Irreversibly binds to ADP receptors on platelets to inhibit platelet activation and aggregation

Question 4

Warfarin

Answer 4

Inhibits production of vitamin K to prevent production of Factors II, VII, IX, X, and proteins C and S

Question 5

Alendronate

Answer 5

Inhibits osteoclast activity to prevent bone resorption

Question 6

Lisinopril

Answer 6

ACE-inhibitor: prevents the conversion of angiotensin I to angiotensin II to suppress the renin-angiotensin-aldosterone system, dilates the efferent tubule to decrease outflow resistance

Question 7

Furosemide

Answer 7

Loop diuretic: inhibits the Na+-K+-Cl- symporter in the ascending loop of Henle

Question 8

Levodopa

Answer 8

Dopamine precursor, treats Parkinson’s disease

Question 9

Amantadine

Answer 9

Anticholinergic, treats mild Parkinson’s disease symptoms

Question 10

Carbidopa

Answer 10

Allows lower doses of levodopa to be used for less side effects, treats Parkinson’s disease

Question 11

Bromocriptine

Answer 11

Dopamine agonist, treats Parkinson’s disease refractory to levodopa

Question 12

Selegiline

Answer 12

MAO-inhibitor, prevents the breakdown of dopamine to treat Parkinson’s disease

Question 13

Tolcapone

Answer 13

COMT-inhibitor, reduce the metabolism of levodopa in the treatment of Parkinson’s disease

Question 14

Entacapone

Answer 14

COMT-inhibitor, reduce the metabolism of levodopa in the treatment of Parkinson’s disease

Question 15

Hydroxychloroquine

Answer 15

Antimalarial to treat musculoskeletal and cutaneous manifestations of SLE

Question 16

Donepezil

Answer 16

Anticholinesterase used to treat Alzheimer’s

Question 17

Galantamine

Answer 17

Anticholinesterase used to treat Alzheimer’s

Question 18

Rivastigmine

Answer 18

Anticholinesterase used to treat Alzheimer’s

Question 19

Pyridostigmine

Answer 19

Cholinesterase inhibitor, mainstay of myasthenia gravis treatment

Question 20

Isotretinoin

Answer 20

Retinoid, normalizes follicular desquamation (normalizes abnormal growth and proliferation of keratinocytes) to treat comedonal acne

Question 21

Acetazolamide

Answer 21

Carbonic anhydrase inhibitor used to treat angle-closure glaucoma