PAN

Question 1

PAN Vessel Affected

Answer 1

Medium size arteries:
  Skin
  Nerve
  Gut
  Renal

Question 2

Organs with microaneurysm of arteries

Answer 2

Kidney (70%)
GI (50%)
Peripheral Nerves (50%)
CNS (10%)

Question 3

Mononeuritis Multiplex

Answer 3

Asymmetric sensory and motor neuropathy

Distal, asymmetric axonal neuropathy

Question 4

PAN organs not affected

Answer 4

Lungs

Blood vessels of the renal glomeruli

Question 5

PAN pathology

Answer 5

Patchy
Transmural inflammation (medium/small muscular arteries)
Fibrinoid necrosis
NO granulomas
PMN cells

Question 6

PAN skin

Answer 6

Livedo Reticularis
Nodules
Ulcerations
Ischemia of digits

Question 7

Cutaneous PAN

Answer 7

Nodules/Ulceration of lower legs

Can occur in crops (painful)

Question 8

PAN other organs

Answer 8

Testicle
Ovary
Breast
Eye

Question 9

PAN Diagnosis

Answer 9

Angiography

Biopsy

Question 10

Diff dx for cutaneous PAN

Answer 10

Atrophie Blanche (thrombotic disorder)

Question 11

PAN biopsy skin

Answer 11

Leukocytoclastic Vasculitis

Fibrinoid necrosis

Question 12

PAN Treatment

Answer 12

Prednisone (PO/IV)
Cytoxan (IV Mesna/Leuprolide), Bactrim for PCP
MTX/AZA

Question 13

Leukemia associated with PAN

Answer 13

Hairy Cell Leukemia