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ANTIPARASITARIOS > Paludismo > Flashcards

Paludismo Flashcards

1
Q

Paludismo.

A
  • CLOROQUINA, primaquina, artemetero-lumefantrina.
  • sulfadoxina-pirimetamina.
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2
Q

CLOROQUINA, primaquina, artemetero-lumefantrina

A

Formación de complejos con el grupo hemo:

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3
Q

sulfadoxina-pirimetamina

A

Inhibidores de la síntesis de ácido fólico
-Sulfadoxina inhibe a dihidropteroato
Sintetasa
-Pirimetamina inhibe a dihidrofolato
Reductasa

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4
Q

Formación de complejos con el grupo hemo:

A

CLOROQUINA, primaquina, artemetero-lumefantrina

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5
Q

Inhibidores de la síntesis de ácido fólico

A

sulfadoxina-pirimetamina

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6
Q

Cloroquina

A

Entra a la vesícula ácida y se une a la ferriprotoporfirina IX impidiendo con ello la formación de la hemozoína (hemo polimerizada)

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7
Q

resistencia a cloroquina

A

P. falciparum por mutación en el gen pfcrt -> bomba de eflujo

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8
Q

Primaquina

A

Interfiere con la ubiquinona generando un daño
oxidativo en las mitocondrias del parasito

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9
Q

artemetero-lumefantrina

A

Escisión del puente de peróxido hem-hierro (se produce dentro de la vacuola altamente ácida)
Genera radicales libres → Alquilación y oxidación de proteínas de eritrocitos.

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10
Q

resistencia a artemetero-lumefantrina

A

Aumento del número de gametos de plasmodium

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11
Q

etapa hePática de paludismo

A

Primaquina

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12
Q

X cloroquina

A

Alteraciones en retina o campos visuales.

“X si no ves CLaRO”

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13
Q

x primaquina

A

Deficiencia G6PD
Embarazo
Px LES o AR (por el tx)

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14
Q

x artemetero-lumefantrina

A

Uso concomitante con
inductores del CYP3A4
IH e IR

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15
Q

EA cloroquina

A
  • Bloqueo rama y AV
  • Prolongación QT
  • pancitopenia
  • Sabor desagradable
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16
Q

EA primaquina

A
  • Dolor abdominal
  • Anemia (hemolítica)
  • Metahemoglobinemia
17
Q

EA artemetero-lumefantrina

A
  • prolongación QT
18
Q

interacciones cloroquina

A

antiácidos con Ca y Mg

19
Q

interacciones de primaquina

A

warfarina o fármacos mielotóxicos

20
Q

interacciones de artemetero-lumefantrina

A

hierba de san juan

21
Q

EA de sulfadoxina-pirimetamina

A

Anemia megaloblástica (deficiencia de B9)
Trombocitopenia
Hepatitis
Nefrotoxicidad

22
Q

1º linea Plasmodium

A

cloroquina

23
Q

falciparum y resistentes a cloroquina

A

Artemetero-Lumefantrina

ANTIPARASITARIOS (4 decks)

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