Palliative care Flashcards
Examples of immediate release morphine
Onset of these?
How long do they last?
Oramoprh soln or sevredol tablets
onset 20 mins last 4 hours
Examples of Slow release morphine
Onset of these?
How long do they last?
MST or Zomorph capsules
4 hours
last 12 hours
How do you work out the Opioid PRN dose from the total background dose?
PRN dose is 1/6th of the total 24 background dose
What do you write on the Opioid PRN dose ‘Max’ section?
6x/day
How do you increase the background opioid dose?
Increase by 30-50%
THEN RECALCULATE PRN DOSE
What opioids are preferred in the context of renal failure?
Oxycodone, Fentanyl/Bupre patches
What drugs are usually prescribed with opioids?
A laxative like Senna
Anti-emetic like haloperidol or cyclizine
How long do Fentanyl patches last?
Up to 72 hours
How long do buprenorphine patches last?
5/10/20 MCG last 7 days
35/52.5/70 MCG last 96 hours
Indications for opioid patches?
Stable pain, renal failure, cannot take oral medication
Signs of opioid Overdosing?
Confusion Drowsiness Myoclonic jerks Hallucinations Pinpoint pupils RR<10
Conversion rate for oral morphine to:
1) SC morphine
2) SC Diamorphine
1) oral to SC morphine then DIVIDE BY 2
2) Oral morphine to SC Diamorphine then DIVIDE BY 3
Immediate release oxycodone name?
Slow release oxycodone name?
Immediate release oxycodone name- Oxynorm
Slow release oxycodone name- Oxycotin
Indications for a syringe driver?
Does this indicate EoL?
Cannot swallow LoC/Dec Consciousness Persistent N&V Intestinal obstruction Malabsorption of drugs
Important to explain that this does not indicate EoL!
Analgesic ladder
1- Non-opioids
2- Weak opioids like Co-codamol 30/500
3- Strong opioids
+/- Adjuvants like NSAIDS/Amitryptiline, Gabapentin, AD, Corticosteroids
Good treatments for bone pain
NSAIDS +/- RT/Bisphosphonates
Good treatment for bowel obstruction pain
Hyoscine butylbromide + Analgesic ladder
Treating headache due to raised ICP
Corticosteroids + NSAIDS/Paracetamol
Neuropathic pain treatment
Amitryptiline or Gabapentin
Symptoms of N&V due to gastric stasis/irritation?
Treatment?
Sudden sickness, relief upon vomiting, heart burn
Metoclopramide B/C pro-kinetic
Causes of gastric stasis/irritation?
Stomach cancer, liver mets, Ascites, Dexamethasone, NSAIDS, Aspirin
Symptoms of N&V due to toxicity?
Treatment?
Constant sickness, vomiting does not provide relief, retching
Haloperidol or cyclizine
Can then try levomepromazine