Palliative Care Flashcards
what are the 3 main domains of palliative care?
1) physical
2) psychosocial
3) spiritual
what is palliative care?
discipline dealing with supportive care, end of life care, terminal care and bereavement support.
with ageing population and most people wanting to die at home this is becoming more relevant.
symptomatic relief important as it reduces QoL, causes distress and results in admissions.
what are the 3 Bs that cause nausea and vomiting?
1) Bowels - mucositis, constipation, infection, obstruction
2) Brain - raised ICP
3) Biochemical - medications, hypercalcaemia, uraemia, infection, hypomagnaesaemia
what 4 systems act on the vomiting centre leading to nausea? and what neurotransmitters work in each?
1) Vestibular system - motion sickness/vertigo - H1, muscAc
2) Limbic system - emotion and hyponatraemia - neurokinin 1 + GABA + 5HT3
3) Chemoreceptor trigger zone - base of V4, uraemia, drugs, chemotherapy, hypercalcaemia - 5HT3 + D2
4) gut wall - distension stimulates vagus - constipation, obstruction, chemo - 5HT3
learn anti-emetic use and side effects
?
why shouldn’t you prescribe cyclizine and metoclopramide?
metoclopramide (D2) is a prokinetic and can cause diarrhoea.
cyclizine (H1, antiMusc) is constipating.
they counteract each other in the bowels.
what are the different treatment goals in managing pain?
1) good night’s sleep
2) pain free at rest
3) pain free on movement
trying to control background and breakthrough pain (PRN vs regular modified release)
what are the simple analgesics and key things to be aware of for each
paracetamol - liver impairment, cachexia
NSAIDs - renal impairment, low platelets. CI in GI bleed, asthma. meds: warfarin, digoxin, steroids.
what are the weak opioids and what should you be aware of for them?
codeine, dihydrocodeine, tramadol.
all have a ceiling effect - so REPLACE them with strong opioids rather than adding them together.
what are the strong opioids and what should you be aware of for them?
morphine, diamorphine, oxycodone, buprenorphine, fentanyl.
specialist palliative care ones - alfentanil, methadone, ketamine.
beware - opioid naive, renal impairment, driving, prescribe for SEs, patient stigma
give some general tips for prescribing opioids
start low and go slow, titrate according to pain and need for PRN meds.
PRN dose = 1/6th of 24hr dose.
deal with SEs - stimulant laxatives + PRN antiemetics.
common SEs - constipation, nausea, sedation, dry mouth.
less common - myoclonus and confusion.
rare - resp. depression and pruritus.
what things are required to produce a legal CD prescription?
Indelible ink
Patient demographics: name + address + age <12
Drug name and formulation
Route
Frequency
Formulation
Strength
Total quantity in words and figures
Signed with name written
Dated (only valid 28 days)
give some basic info on fentanyl
used for stable opioid responsive pain.
indicated if poor oral route or renal impairment.
takes 12hrs to reach analgesic concentration so not for acute pain (lasts 72hrs).
25mcg fentanyl patch = 90mg morphine/24hrs.
what are some adjuvant analgesics?
- antidepressants - neuropathic pain e.g. amitryptiline
- antiepileptics - neuropathic pain e.g. pregabalin, gabapentin
- antispasmodics - muscle spasms e.g. baclofen
- steroids - compression symptoms e.g. dex
- benzodiazepines - spasms e.g. clonazepam, diazepam
- bisphosphonates - bone pain e.g. zolendronic acid
what is terminal care?
likely to die in next 12 months or death imminent.
preparation helps with symptom management, QoL, practical and personal preparation, carer support.
key concepts - formal advanced care planning (advanced statement, power of attorney, advanced decision to refuse treatment), DNACPR (medical decision but should be informed by patient/carers).
how to recognise dying - change in symptoms, sudden deterioration. last days (2-14 days of daily deterioration) + last hours (body is shutting down)
