Pales Coagulopathy CIS Flashcards
what medications can cause prolonged bleeding time?
Aspirin
NSAIDS
clopidogrel
another -grel
in Type I VWD we typically see
no major symptoms unless there is a reason to bleed
factors tested by extrinsic
7 and Vitamin K
VWD Type N
is a factor 8 problem
autosomal recessive
VWF and RIPA and multimer pattern can all be normal
differential for intrinsic pathway troubles
Hemophilia A, B, VWD, Factor XI deficiency
or acquired- heparin, lupus anticoagulant, acquired vWD, inhibitor of Factors 8, 9, 11, or 12
what test can you do to differentiate between a factor deficiency problem (like hemophilia) from a factor inhibitor problem?
mixed blood test
if the PTT improves then it’s a deficiency, if not it’s an inhibitor
hemophilia A genetics
X linked recessive
mom’s brothers are most important in the family history
what’s the first thing we do when we have an asymptomatic patient with thrombocytopenia?
redraw. “pseudo-thrombocytopenia”- clumping of platelets by EDTA
most common cause of thrombocytopenia in asymptomatic, outpatient settings?
ITP
diagnosis of exclusion
treatment: nothing if asymptomatic
anti-platelet antibodies are not recommended
splenectomy?
three books to read if you want to be a good physician
House of God
How Doctors Think
article called Doctor Nurse Game
3 possible causes of microangiopathic hemolytic anemia
TTP
DIC
HUS
test for heparin induced thrombocytopenia?
Heparin-induced anti-platelet antibodies
tests for hemolysis
haptoglobin
unconjugated bilirubin (indirect)
LDH
disorders that can predispose pts to venous clots
Protein C and S deficiencies
antithrombin 3 deficiency
factor V Leiden
prothrombin mutation
(birth control, smoking, some cancers, stasis)
disorders that can predispose pts to both arterial and venous clots
APA syndrome (anti-phospholipid antibodies)
anti cardiolipin
lupus anticoagulant
hyper homocysteinemia
