Pain treatment and pain research Flashcards
what is trephination?
ancient pain relief technique -> make a hole in people’s skulls to “release evil spirits” which were thought to be the cause of pain
Did trephination work as a pain relief method?
NO
What is theriac?
A combination of plants, flowers, seeds, etc. taken as a pain relief method
what is the active ingredient in theriac?
opium
does theriac work for pain relief
YES
which two plants were used for pain relief in antiquity and are still used today?
willow bark and opium poppy
what was the first pharmaceutical company?
Merck KGaA
what did Merck KGaA figure out how to do in relation to drugs?
they figured out dosage control for morphine (standardized doses) and how to turn opium into morphine so its always the correct dose
where was anesthesia first demonstrated?
the Ether Dome in Boston at MassGen
How is anesthesia administered now for surgeries?
A combination of gas anesthetic and IV line anesthetic
what are opiates and opioids?
drugs that are like opium (ex: morphine)
what is half-life?
the time that it takes for there to
what is special about methadone and its half-life?
it has a long half-life making it less addictive than drugs with a shorter half-life and it also has a longer duration of action
what is the subcutaneous drug administration route?
into the skin - needle does through the epidermis but stops in the dermis
what is the intramuscular drug administration route?
into the muscle - the needle goes through the 3 layers of the skin and blood vessels straight into the muscle
what is the intravenous drug administration route?
into the vein - the needle goes through the 3 skin layers into the vein
what is the transdermal drug administration route?
patch on top of the skin
how does a transdermal patch work?
the active ingredient gets through the epidermis into the lower layers of the skin
what is the advantage of transdermal patches?
there are fewer side effects
what are side effects?
the drug is acting at the right receptor but in the wrong place