Pain, plasticity, volition Flashcards
1
Q
What are the features of a peptidergic C fibre?
A
expresses SP, CGRP neurogenic response IB4 negative expresses trkA, NGF sensitive TRPV1 TRPM8
2
Q
What are the features of non peptidergic C fibre?
A
IB4 positive
expresses RET, sensitive to GDNF
TRPV1
NaV1.9, P2X3
3
Q
What is the structure of the TRPV1?
A
6 tm domains, cytoplasmic C and N terminals
form homo or heterotetramers
activated by noxious heat over 43 degrees, acidity, anandamide and capsaicin
4
Q
Which fibres does NGF act on?
A
A delta
peptidergic C
