Pain Management unit 1 Flashcards
Pharmacotherapeutic Intervention
By mouth
*By clock
*By ladder
By the
mouth
the least invasive and safest method.
By the
clock
most oral analgesics act only for 4 hours or less,
should be prescribed 4 hourly to achieve therapeutic effects.
By the
ladder
WHO’s pain ladder
- dose must be titrated until:
- the maximum recommended dose is reached
- the pain is relieved
- or the patients experience serious side effects.
WHO’s Pain Ladder
step 1
STEP 1
Non-opioids
Paracetamol, NSAID,
COX-2 inhibitors
± adjuvant analgesic
WHO’s Pain Ladder
step 2
STEP 2
Weak opioids
Tramadol, Codeine
± adjuvant analgesic
WHO’s Pain Ladder
step 3
Strong opioids
Immediate release:
Morphine solution
Oxycodone
Methadone
Controlled release:
Morphine Sulphate Tab
Oxycontin
Transdermal Fentanyl
Adjuvant
Analgesics
Helpful in neuropathic pain, can be added in any
steps in WHO Pain Ladder
Tricyclic antidepressants
Anticonvulsants
-Gabapentin
-Pregabalin
Topical
-Lignocaine
Steroid
-Dexamethasone
Morphine
Commonest strong opioid used for palliative patients.
Used for moderate to severe pain; and dyspnea.
- Liquid:
- Mist Morphine Solution (1mg/ml)
- Oramorph Morphine syrup (2mg/ml)
- RA-Morph(Rapid Acting) Morphine solution (1mg/ml)
- Tablet: Morphine Sulphate (Sustained-Released) Tablet, also known as MST (10mg /30mg tablets). Cannot be cut/crushed.
- Injectable: Per ampoule Morphine (10mg/ml) given subcutaneously or
intravenously
Liquid morphine
Mist Morphine Solution (1mg/ml)
* Oramorph Morphine syrup (2mg/ml)
* RA-Morph(Rapid Acting) Morphine solution (1mg/ml)
Tablet morphine
Morphine Sulphate (Sustained-Released) Tablet, also known as MST (10mg /30mg tablets).
Cannot be cut/crushed.
Injectable morphine
Injectable: Per ampoule Morphine (10mg/ml) given subcutaneously or
intravenously
Common side effects of Morphine
constipation, nausea, vomiting, sedation and confusion.
_______________ are needed for ALL patients on Morphine.
Laxatives
Morphine Toxicity
Myoclonic jerks, pinpoint pupils and respiratory depression
Fentanyl
Is a safe strong opioid in moderate to severe renal failure
- More potent than Morphine Ratio is 1:100
- Doses are the same for transdermal, subcutaneous and
intravenous routes. - Transdermal Fentanyl patch:
- 12mcg/hr
- 25mcg/hr
- 50mcg/hr
Transdermal Fentanyl takes about _______ hrs to have its maximal
effects and has similar residual effect ________ after it is removed.
Last for about ____________ hrs.
about 8-12hrs to have its maximal
8-12 hrs
72
Fentanyl indications (7)
When orally intake is not possible (nausea and vomiting).
- Difficult compliance to Oral Morphine.
- Patient develops side effects or toxicity of Morphine and the need to
opioid rotate. - Severe constipation with Morphine.
- Renal impairment
- Liver impairment
- Patient is averse to Morphine but agreeable to use another strong opioid.
Fentanyl side effect
Similar to Morphine but less constipation
Fentanyl Usual dose (Start)
Transdermal: 6mcg/hr q72H (use half of a 12mcg/hr patch)
Infusion (SC): 10mcg/hr (0.2 ml/hr)
Opioids in Renal
Failure
Caution is required when
estimated creatinine clearance
falls below 30ml/min, whether
or not a patient is on dialysis
Fentanyl is recommended in
moderate to severe renal
impairment
Opioids in
Liver Failure
Fentanyl is the opioid of choice
in patients with moderate to
severe liver failure or cirrhosis
Other opioids may be used with
caution (by decreasing dose and
frequency) and careful
monitoring for side effect
Guide to the use of opioids
- Educate patient/caregiver
in the use of opioid - Advise about the
common side- effects - Empower
caregiver to
manage side
effects. - Address concerns
about opioid use.
Non-pharmacotherapeutic
Intervention
Address the concept of “Total
Pain” in holistic dimensions.
- Appreciate the role of
multidisciplinary team in
managing “Total Pain”
Non-pharmacotherapeutic
Intervention (Examples)
Examples:
- Radiotherapy
- Palliative
surgery - Physiotherapy/
Occupational
therapy - Transcutaneous
Electrical Nerve
Stimulators
(TENS)
Examples:
* Massage
therapy
* Acupuncture
* Music therapy
* Art therapy
* Namaste
Namaste care
“Honour the spirit within”
- Structured programme for
person living with Advanced
Dementia - Incorporates sensory
intervention, social contact
and environmental
modification