Pain (assessment and management)

Question 1

Anti-psychotics MOA

Answer 1

Dopamine receptor antagonist

Question 2

Anticonvulsants MOA

Answer 2

Calcium and sodium channel antagonists

Question 3

Opioids MOA

Answer 3

Inhibit release of excitatory neurotransmitters

Question 4

NSAIDs MOA

Answer 4

Reduce prostaglandin synthesis

Question 5

Tricyclic antidepressant MOA

Answer 5

Inhibits neuronal re-uptake of noradrenaline and serotonin from the synaptic cleft

Question 6

Tolerance

Answer 6

Subjects diminished reaction to a drug over time

Question 7

Physical dependence

Answer 7

Negative symptoms following abrupt discontinuation of the substance

Question 8

Addiction

Answer 8

Physical and emotional dependence on a substance

Question 9

Opioid induced hyperalgesia

Answer 9

Paradoxical response whereby patients experience more pain with increased opioid exposure

Question 10

Combinations to avoid

Answer 10

Sotalol and amitriptyline -> QT prolongation and arrhythmias

Question 11

Ganglion of impar block

Answer 11

Visceral pain from rectum / perineum / anus

Question 12

Superior hypogastric plexus

Answer 12

Pelvic organs