Pain

Question 1

Nociception and pain

Answer 1

• Nociception is the sensing of stimuli that are potentially harmful to the body.

Question 2

the neuronal basis of pain

Answer 2

Recordings from nociceptors and non-nociceptive thermoreceptors

Question 3

____________________ respond to a wide range of stimuli while the___________________ respond to temps that are more noxious

Answer 3

Thermoreceptors, nociceptors

Question 4

Pain circuit

Answer 4

• Nociceptors in the thumb/skin

Question 5

synaptic plasticity in pain

Answer 5

• Occurs in pain circuits

Question 6

Postsynaptic mechanisms of synaptic plasticity

Answer 6

• Changes important for LTP which is important in pain sensivity; increase/decrease

Question 7

Presyantic mechanisms of synaptic plasticity

Answer 7

Presyanptic mechanisms of synaptic plasticity

Question 8

activity dependent presyantic plasticity at nociceptive synapse

Answer 8

Structural changes occur

Question 9

activity dependent postsynaptic plasticity at nociceptive synapse

Answer 9

• Post synaptic side

Question 10

Microglia-neuron interactions in the spinal cord are crucial to pain hypersensitivity induced by peripheral-nerve injury

Answer 10

• In mice lookin at how injury can induce increase in pain sensitivity

Question 11

Sex differences and pain

Answer 11

• Experiment done on males and females

Question 12

why does pain sensitivity differ in males and females

Answer 12

• Injury induced leads to BDNF released …….has effects on NMDA receptors ….inhibiting KCC2 increasing pain

Question 13

Social communications and pain

Answer 13

• Studies on mice

Question 14

Human and animal models of nociception and pain

Answer 14

• Advantages and disadvantage when looking at diff models

Question 15

Nociceptors in drosophila are analogous to nociceptors in _______________

Answer 15

Mammals

Question 16

When blue light is show larvae will _________________________________ due to presence of optogenetics

Answer 16

Curve and roll to escape

Question 17

____________________________________ can trigger the response to optogenetics

Answer 17

Activity sensory neuron

Question 18

Whe mechanical or thermal probe the larvae will _______-

Answer 18

Crawl

Question 19

When hot probe which activates nociceptors in large we get _______motion

Answer 19

Rolling

Question 20

___________ channel, encoded by the painless gene is required for nociception

Answer 20

TRP

Question 21

_____________ channels negatively regulates nociception

Answer 21

Potassium