Paget's Disease Flashcards
1
Q
cause
A
viral/environmental/biochemical trigger in a genetically predisposed individual
2
Q
what bones does this affect?
A
long bones
pelvis
lumbar spine
skull
3
Q
who does this present in?
A
incidence increases with age
4
Q
what happens
A
there is abnormal osteoclastic activity with increased osteoblastic activity leading to abnormal bone structure
5
Q
presentation
A
bone pain deformity increased CO due to bone vascularity increased limb volume deafness (bony meatus compression) compression neuropathies osteosarcoma is rare complication
6
Q
diagnosis
A
XR and isotope bone can show distribution of disease
high ALP with normal LFTs
7
Q
management
A
bisphosphonates for pain if not responding to analgesia
