Paediatrics Flashcards
Jaundice differentials in a baby
Depends on timing
<2days => ABO incompatability or rhesus incompatability
Sepsis
2 days - 2 weeks G6PD Hereditary spherocytosis Sepsis Breast milk jaundice
> 2weeks
Biliary atresia
Causes of failure to thrive
Increased energy requirement => chronic issue =>CF, hyperthyroidism
Malabsorption = coeliac
Poor intake/neglect
(ask about school and mental health) or issue with feeding e.g. cleft palate
Features of failure to thrive
Crossing growth centiles
Child persistently in the bottom 5th percentile
Investigation and management of failure to thrive
Ensure adequate nutrition
Ensure social support and support at school as well as financial support
Ix for any potential Dx = sweat test, anti-TTg, FBC (anaemia), TFTs (hyperthyroidism)
Organic cause in <5%!
Dietician
Regular appointments to check progress
Factors that determine good growth in a child
Adequate intake Endocrine levels Co-morbidities Emotional health (supported child)
Until which age should you correct height/weight etc. for prematurity?
2 years old
Whats the cut off for concern for number of centiles crossed?
2
By what age should a baby have doubled their original weight?
Around 4 months
Average age of puberty in females
11
Order of puberty development in females
Breast budding
Pubic hair
Menarche
Cut offs for precocious puberty in males/females
<8 for females
<9 for males
Causes of precocious puberty
Central (most common), just normal puberty happening earlier
Peripheral = intracranial tumour, endocrine tumours e.g. McCune Albright syndrome
Congenital adrenal hyperplasia
Ix for precocious puberty
Brain MRI to rule out central tumour
USS of ovaries/testis to assess size + determine if gonadal tumour present
Endocrine levels
Mx of precocious puberty
Ix to rule out sinister causes
Give GnRH analogues to delay puberty and help with development and mental health
Causes of delayed puberty
Late bloomer (most common, check with hand bone xray)
High gonadotrophin secretion
Kallmans syndrome
Turner’s syndrome
Low gonadotrophin secretion
Pituitary tumour
Systemic issues such as CF or Crohn’s
Definition of delayed puberty in boys and girls
No pubertal development by the age of 14 in girls and 15 in boys
Most common cause of delayed puberty
Late bloomer
First line tests for delayed puberty
Hand xray for bone age
LH and FSH levels to rule out gonadotrophin issues
Symptoms of acute lymphoblastic leukamia (ALL)
Any children presenting in GP with bruising, enlarged lymph nodes and systemic illness should be referred for specialist assessment.
Lymphadenopathy is the most common sign in ALL.
Other symptoms which may be present include: hepatosplenomegaly, pallor or petechiae, fever, fatigue, dizziness, weakness, and epistaxis.
Congential disorder that increases the risk of ALL
Down’s syndrome
Diagnosis of ALL
Firstly do FBC and blood film
Bone marrow biopsy
Remember to screen for coagulopathy
Features of child with bone cancer
FLAWS Limp or bone painn Ask about pain at NIGHT Ask if any signs of trauma Rule out NAI
Causes of short stature
Familial Delayed puberty (this tends to catch up) Nutritional Chronic illness Genetic (Turner's and Down's) Thyroid issues GH deficiency Chronic steroid use (e.g. Crohn's or another chronic illness)
Ix for short stature
Growth charts (plot mid parental height)
Bloods for FBC, thyroid, CRP, U&E
Imaging of bones
Who should manage children with endocrine issues?
Paediatric endocrinologist
How do you calculate predicted height for a boy/girl
Mum + Dad + 13 all divided by 2 for a boy
- 13 for a girl
DDx or jaundice in a child
Pre-hepatic => haemolysis = G6PD, SCD, AIHA, HUS
Hepatic => Gilbert’s, hepatitis
Post-hepatic => Gallstones
Neurological symptoms of jaundice indicate…
Kernicterus
Management of jaundice in a newborn
Try to rule out sinister causes of jaundice
Plot on a bilirubin chart and use phototherapy or exchange transfusion if severe (very high levels)
Symptoms of croup
Viral URTI progressing to barking cough
Hoarse cry
Inspiratory stridor
Respiratory distress in severe cases
Symptoms get worse when the child is distressed
Fever
Most common cause of croup
Parainfluenza virus
Causes tissue swelling and oedema, limiting airflow and causing stridor
Signs of respiratory distress
Nasal flaring Pursed lips Head bobbing Tracheal tug Intercostal recessions Subcostal recessions Use of abdominal muscles (belly breathing) Frightened look Sweating due to increased work Grunting
DDx for croup
Croup
Bacterial tracheitis (similar but with purulent secretions)
Epiglottitis
Foreign body (for the stridor)
Mx of croup
Admit if <6mo or severe
Give wafted O2
Single dose of dexamethasone
Nebulised adrenaline
What is bronchiolitis?
LTRI infection of infants between 2-6 months old
What causes most cases of bronchiolitis?
RSV
RF for severe bronchiolitis
Prematurity
Chronic lung disease
Typical features of bronchiolitis
Coryzal symptoms (fever, snotty nose and cough)
Then get LRTI Sx like dry cough and WHEEZE
They go off their feeds
Ex shows fine inspiratory crackles, widespread wheeze
Fever
Dx of bronchiolitis
Nasopharyngeal aspirate for rapid RSV testing incase you want to isolate them
DDx for bronchiolitis
Viral wheeze
Asthma
Pneumonia
Mx of bronchiolitis
Usually self-limiting unless signs of severe disease = hydration, antipyrexial meds such as ibuprofen and paracetamol
Hospital admission if: Poor feeding (<50% normal), resp distress, low O2 sats, Hx of apnoea, resp rate >70
Mx in hospital = oxygen and NG feeding
Definition of pneuomia
LRTI with radiological changes (this is how you differentiate from croup and bronchiolitis)
Common causes of pneumonia
S. pneumoniae, H influenzae, S aureus
A typical = M pneumonia
Diagnoses to consider in an unwell, febrile child
Pneumonia
UTI
Meningitis
Features of pneumonia in infants
Cough Fever Preceded by URTI Sx Signs of respiratory distress SPUTUM
Mx of pneumonia in children
Antibiotics
Anti-pyrexials
Consider admission if signs of repsiratory distress or low O2 sats
Why dont we use aspirin in young children <16yo?
Reyes syndrome
Most common cause of epiglottitis
H influenzae
Symptoms of epiglottitis
Child stooped forward Drooling Dyspnoea Looks toxic High temperature
Mx of suspected epiglottis
Keep the child calm and give wafted O2 and nebulised adrenline
Get the crash trolley
Alert senior and anaesthetist as well as ENT
Intubate the patient
IV antibiotics
IV steroids and IV maintenance fluids
Features of a viral wheeze
SYMPTOM FREE BETWEEN BOUTS
Precipitated by viral infection e.g. coryzal
Unpredictable, non-sterotyped response
Features of asthma
Precipitated by triggers May be wheezy in the interim Responds to B agonist History of atopy Night time cough
Symptoms of pertussis infection
Dry hacking cough Continuous cough Petichae on face Child looks unwell Afebrile
Mx of pertussis infection
Supportive :(
Features of a life threatening asthma infection
Hypotension Silent chest Unable to talk Confusion Coma Exhaustion PEFR <33%
Mx of asthma (chronic)
SILLI