Paediatrics Flashcards
Sepsis definition
life threatening organ dysfunction caused by a dysregulated host in response to an infection
Toxic shock syndrome
septic shock caused by superantigens produced by toxin-producing staph aureus or strep pyogenes
High risk factors for sepsis
<2months premature unimmunised immune def/supp asplenic indwelling lines malignancy (neutropenic) recent surgery
Sepsis abx <2months
Amp 50mg/kg
Gent 7.5mg/kg >1month or 4mg/kg <1month
+ cefotaxmine 50mg/kg meningitis
Sepsis Abx >2months
cefotaxime 50mg/kg max 2gr
cipro 10mg/kg max 500mg if pen anaphylax
Septic shock:
Add gent 7.5mg/kg and vanc 15mg/kg max 750mg
Septic shock PICU criteria
fluid non-responder 40ml/kg inotropes reduced LoC hypotension coagulopathy/DIC lactate>4 toxic shock
Blood culture volumes
neonatal aerobic 1ml+
standard bottles 4ml+
Targets for fluid resus
U/O 1ml/kg/hr
improved mental state
nomal HR
CRT <2 normal perfusion
TSS abx
cefotaxime 50mg/kg
lincomycin 15mg/kg (max 1.2gram)
Adrenaline doses
push dose 1mcg/kg infusion 0.05-0.1mcg/kg/min Can go higher but more side effects === add 1ml of 1:10,000 to 9ml n.saline = 10mcg/ml
==
Cardiac arrest 10mcg/kg
Calcium gluconate doses
Calcium gluconate 10% in 10ml
0.5ml/kg = 0.11mmol/kg
IV hydrocortisone dose
1mg/kg if known adrenal insufficiency or intotrope resistant
Septic shock DDx
Anaphylaxis cardiogenic shock inc congential cardiac, duct dependent lesions obstructive shock neurogenic shock hypovolaemic shock congential metabolic disorder
warm shock
vasoplegic wide pulse pressure flash CRT tachycardia bounding pulse
cold shock
vasoconstricted narrow PP tachycardic slow CRT tend to be younger
Sepsis Ix
Blood culture VBG - lactate base deficit Co2 glucose FBC - plt (DIC) WCC (hi or lo) ECU - Cr AKI Coags (DIC) LFTs - hi bili ALT if liver failure from MODs LP - ?meningitis and no features of raised ICP
LP in septic shock
Do not delay abx do not perform if child has Reduced LoC Focal neuro signs Raised ICP sx Haemodynamic instability resp compromise
send for WCC and PCR
Sepsis signs
fever hypothermia AMS (lethargy or agitated) abnormal HR, RR, CRT petechia / purpura / widespread erythema
Resus end points
CRT<2 Normal BP for age Normal HR warm U/O 1ml/kg/hr normal mentation o2 sats >92%
NETS referral - Airway
airway obstruction - mod+ distress
Croup + 2 adrenaline + ongoing distress
symptomatic FB
post tonsil haemorrhage
NETs referral GI
button battery FB - vomiting, secretions, drooling, unable to eat acute GIB insussception+shock surgical abdo
NETS referral Resp
Despite max tx hypoxia apnoeic events resp support required severe distress congenital heart/lung dx mediastinal mass
NETS referral Neuro
Raised ICP signs VPshunt dysfunction ICH with hi ICP meningitis with shock/seizures/raised ICP Status epilepticus TM or GBS (potential to deteriorate)
NETS referral cardiac
congenital disease + resp distress poor perfusion arrhythmia Altered LoC