Paediatrics Flashcards
Sepsis definition
life threatening organ dysfunction caused by a dysregulated host in response to an infection
Toxic shock syndrome
septic shock caused by superantigens produced by toxin-producing staph aureus or strep pyogenes
High risk factors for sepsis
<2months premature unimmunised immune def/supp asplenic indwelling lines malignancy (neutropenic) recent surgery
Sepsis abx <2months
Amp 50mg/kg
Gent 7.5mg/kg >1month or 4mg/kg <1month
+ cefotaxmine 50mg/kg meningitis
Sepsis Abx >2months
cefotaxime 50mg/kg max 2gr
cipro 10mg/kg max 500mg if pen anaphylax
Septic shock:
Add gent 7.5mg/kg and vanc 15mg/kg max 750mg
Septic shock PICU criteria
fluid non-responder 40ml/kg inotropes reduced LoC hypotension coagulopathy/DIC lactate>4 toxic shock
Blood culture volumes
neonatal aerobic 1ml+
standard bottles 4ml+
Targets for fluid resus
U/O 1ml/kg/hr
improved mental state
nomal HR
CRT <2 normal perfusion
TSS abx
cefotaxime 50mg/kg
lincomycin 15mg/kg (max 1.2gram)
Adrenaline doses
push dose 1mcg/kg infusion 0.05-0.1mcg/kg/min Can go higher but more side effects === add 1ml of 1:10,000 to 9ml n.saline = 10mcg/ml
==
Cardiac arrest 10mcg/kg
Calcium gluconate doses
Calcium gluconate 10% in 10ml
0.5ml/kg = 0.11mmol/kg
IV hydrocortisone dose
1mg/kg if known adrenal insufficiency or intotrope resistant
Septic shock DDx
Anaphylaxis cardiogenic shock inc congential cardiac, duct dependent lesions obstructive shock neurogenic shock hypovolaemic shock congential metabolic disorder
warm shock
vasoplegic wide pulse pressure flash CRT tachycardia bounding pulse
cold shock
vasoconstricted narrow PP tachycardic slow CRT tend to be younger
Sepsis Ix
Blood culture VBG - lactate base deficit Co2 glucose FBC - plt (DIC) WCC (hi or lo) ECU - Cr AKI Coags (DIC) LFTs - hi bili ALT if liver failure from MODs LP - ?meningitis and no features of raised ICP
LP in septic shock
Do not delay abx do not perform if child has Reduced LoC Focal neuro signs Raised ICP sx Haemodynamic instability resp compromise
send for WCC and PCR
Sepsis signs
fever hypothermia AMS (lethargy or agitated) abnormal HR, RR, CRT petechia / purpura / widespread erythema
Resus end points
CRT<2 Normal BP for age Normal HR warm U/O 1ml/kg/hr normal mentation o2 sats >92%
NETS referral - Airway
airway obstruction - mod+ distress
Croup + 2 adrenaline + ongoing distress
symptomatic FB
post tonsil haemorrhage
NETs referral GI
button battery FB - vomiting, secretions, drooling, unable to eat acute GIB insussception+shock surgical abdo
NETS referral Resp
Despite max tx hypoxia apnoeic events resp support required severe distress congenital heart/lung dx mediastinal mass
NETS referral Neuro
Raised ICP signs VPshunt dysfunction ICH with hi ICP meningitis with shock/seizures/raised ICP Status epilepticus TM or GBS (potential to deteriorate)
NETS referral cardiac
congenital disease + resp distress poor perfusion arrhythmia Altered LoC
NETS referral endocrine
DKA +
<5 yr
pH <7.15 after 2 hours
severe headache / altered LoC
NETs referral systemic
septic shock / TSS
anaphylaxis with ongoing sxs despite tx
pain OOP to clinical exam findings
Non-pharma pain Mx
Immobilise RICE Dressings distract toy/bubbles/phone Swaddle Skin to skin Feeding / dummy Breathing techniques
Sucrose dose
PO 0.1-0.5ml 2mins pre-procedure
max 5ml/day <3month
max 10ml/day >3month
Paracetamol dose
PO 15mg/kg/day IBW
4-6hourly (IV Q6H)
Max 90mg/kg/day >1month
Ibuprofen dose
PO 10mg/kg/day 6-8hourly
max 30mg/kg/day
2.4gram max
Fentanyl dose
IN 0.75-1.5mcg/kg
Max 75mcg Q10min
Divide between nostrils
IV 0.5-1mcg/kg Q5-10min
Oxycodone dose
PO >12months
0.1-0.2mg/kg Q4hr
max 5-10mg dose
Morphine dose
IV up to 0/05-0.2mg/kg
max 5-10mg 2-4hourly
Moderate dehydration (5-9%) signs
tachy lethargy tachypnoea sunken eyes dry MM decreased skin turgor CRT >2
Severe dehydration -(>=10%) Shock
Reduced LoC Tachy Tachypnoea / kussmaul hypotensive pale/mottled cold weak pulse decreased skin turgor CRT >2++ Deeply sunken eyes
IVF bolus
0.9% NaCl
10-20ml/kg
max 40ml/kg then likely need inotropes
IVfluid maintenance calc
0.9%Nacl+5% glucose
4-2-1 rule ml/hr
4ml/kg 1st 10kg =4xweight 2ml/kg next 10kg =40ml + 2x(weight-10) 1ml/kg up to 60kg =60ml + (weight-20)
- 2/3 rate for unwell kids
- Replace 5% over 24hours then remainder over next 24hours
Seizure Tx
Midazolam x2
IN/IM 0.3mg/kg
IV/IO 0.15mg/kg
Levetiracetam
IV 40mg/kg over 5m (max 2.5gram)
Phenobarbitone <1yr
20mg/kgover 20min (<1gr)
Intubate - propofol 2-3mg/kg Roc 1.2mg/kg
Hyperkalaemia Tx
(5 drugs)
- Calcium gluconate 10%
0. 11mmol/kg - 10% dextrose 5ml/kg/hr
- Actrapid 0.1u/kg/hr
- Furosemide 1mg/kg
- Sodium bicarbonate 8.4% 1mmol(1ml)/kg
Hypertonic saline dose
3% NaCl 3ml/kg over 10mins large vein
Intubation medication
ketamine 1-2mg/kg
200mg/2ml dilute to 20ml (10mg/ml)
Rocuronium 1.2mg/kg
50mg/5ml vial (10mg/ml)
60sec onset
Fentanyl 1mcg/kg pain
2-5mcg/kg induction
100mcg/2ml, dilute to 10ml (10mcg/ml)
Propofol 2-3mg/kg
Mag sulfate dose
0.2mmol/kg over 20mins if pulse present
10mmol/5ml
APLS Intervention (4)
15:2 compression/vent
Adrenaline 10mcg/kg
Defib 4j/kg
Amiodarone 5mg/kg after 3rd shock if shockable
Weight estimate
(age+4)x2
ETT tube sizing
Age/4 + 3.5 for cuffed
Glucose dose
10% dextrose 2ml/kg
BP normal estimate
Agex2 +65mmHg
ETT tube depth estimate
> 1yr Age/2+13
<1yr weight/2 +8
Vital normal ranges Simplified 0-6month 6-12month 1-4years
0-6month
HR 80-180
RR <40
BP 60-90
6-12month
HR 70-150
RR <35
BP 90-100
1-4
HR 70-120
RR 20-30
BP 100
> 4 like adults
Unsettled baby red flags (3)
sudden onset irritability/cry
Parental PND
NAI risks as sign of abusive head trauma
Unsettled baby DDx (8)
NAInjury incarcerated inguinal hernia / torsion sepsis / infection hair tourniqet corneal abrasion?? Raised ICP Non-IGe cows milk allergy
Acute abdo pain
Non-abdominal causes (9)
DKA HSP Pneumonia Hip pathology UTI/pyelo testicular torsion sepsis sickle cell VOcrisis toxins/OD
Acute abdo pain Ix
urine - culture UTI ketone /glucose DKA protein/casts AKI/HSP pregnancy
VBG - pH, base deficit, electrolytes, lactate
EUC - Cr AKI
BSL - DKA, sepsis hypo
LFT, lipase
USS - appendix/pyelo/ureteric calc/cholecystitis/intersussception/ ovarian torsion
AXR -obstruction
CXR - pneumonia
Neonatal acute abdomen
DDx (5)
hirschsprung enterocolitis Nec enterocolitis incarcerated hernia volvulus intersussception
Infant/child Acute Abdo DDx (9)
pyloric stenosis meckel's diverticulum incarcerated hernia volvulus intersussception abdominal trauma appendicitis ovarian torsion testicular torsion
Adolescent acute abdo DDx (9)
ectopic pregnancy IBD PID pancreatitis cholecystitis appendicitis ovarian torsion testicular torsion abdominal trauma
Trauma team activation
10
Abnormal vitals for age GCS<9 specific injuries including- spinal flail chest major vascular penetrating/crush/severe blunt to head or torso limb amputation burns>20% BSA or inhaled Multiple body regions
I-MIST-AMBO handover
ID - name, age, weight MOI Injuries/info Signs (inc first, worst, recent) Tx to date Allergies Meds B/G Other - fam contact
NAI Concerns (5)
Delay in seeking tx despite signif injury
Inconsistent hx over time or between caregivers
MoI inconsistent with developmental stage
caregiver impairment
Allegation raised by caregiver/child
<12months most common
NAI injury patterns (12)
Bruise
#
Bleed
bruising (<9months) face/ears/buttocks/back bruising in shape of object/ligature Multiple injuries at different stages of healing or bilateral torn frenulum long bone # (exc toddler #) posterior rib # skull (non-parietal) metaphyseal, bucket handle scapular # sternal #
Retinal haemorrhage
ICH
Paeds airway differences (8)
smaller oral cavity larger tongue larger occiput flex forward if flat obligate nasal breather <6months larynx higher +anterior (c2/3) larger epiglottis projects posteriorly cricoid narrowest point susceptible to oedema shorter trachea - ETT dislodgement
Paeds breathing differences (3)
ribs horizontal - limits TV diaphragmatic breathers (need stomach decomp) less type 1 fibres so fatigue quicker higher met rate - increased o2 demand
Circulating blood vols neo infant child adult
90ml/kg neo (NN)
80ml/kg infant (EEnfent)
70ml/kg child
65ml/kg adult
Paeds circulation differences (6)
smaller blood vol overall lower systemic vasc res hypotension/bradycardia late signs U/O 1-2ml/kg/hr fixed SV so need to increase HR to inc CO smaller vessels, hard access
Peads D + E differences
(4 + 2)
ant font open <18months
thinner cranial bones
larger head, higher centre of gravity inc head trauma
fulcrum c1-2 so higher c-spine injuries
larger SA:BM ratio, increased heat loss
Inc glucose requirement as lower glycogen stores
increased BMR
Asthma definition
chronic inflammatory disease of airways characterised by reversible airway obstruction, hyper-responsive airways and bronchospasm
What is breath stacking?
Increased autoPEEP due to increased resistance leads to dynamic hyperinflation due to air trapping
Unable to expire full breath during expiratory time
Asthma DDx (7)
ANAPHYLAXIS Inhaled FB pneumonia bronchiolitis congenital - laryngomalacia CF GORD
Asthma Red Flags (5)
previous ICU poor adherence poor control brittle asthma hx anaphylaxis
Asthma useful exam findings (3 main)
- WoB - accessory muscle, recession, tug
- General appearance
- Mental status
nb wheeze intensity, tachycardia after salbutamol, ability to talk, initial 02 less helpful.
Asymmetrical lung sounds in ?asthma DDx
Mucus plugging
pneumothorax
inhaled FB
pneumonia
INH Salbutamol dose
100mcg/puff via spacer
<6 6puffs
>6 12 puffs
20mins x3
INH Ipratropium dose
21mcg/puff via spacer
<6 4 puffs
>6 8 puffs
20mins x 3 max 1 hour
Asthma steroid doses
PO pred 2mg/kg max 60mg stat then 1mg/kg/day
IV methylpred 1mg/kg Q6hr
IV hydrocort 4mg/kg max 300mg Q6Hr
Asthma MgSO4 dose
MgSO4 50%
vial is 10mmol/5ml
1ml=2mmol=500mg
dilute to 10mmol/50ml
- > 0.2mmol/ml
DOSE 0.2mmol/kg over 20 max 8mmol (40kg)
Asthma 02
If sats persist below 90%
HUMIDIFIED
IV salbutamol dose
15mcg/kg/min over 10mins
1-2mcg/kg/min