Paediatrics Flashcards
What are the main 3 types of anaemia? State the mass of the RBC in each
Microcytic: <80
Normocytic: 80-100
Macrocytic: >100
State the causes of microcytic anaemia
Fe2+ deficient anaemia
Anaemia of chronic disease
Thalassemia
State the causes of normocytic anaemia
Increased reticulocytes: haemolytic anaemia, blood loss
Decreased reticulocytes: bone marrow disorder
State the causes of microcytic anaemia
Megaloblastic: Vitamin B12/folate deficiency
Non-megaloblastic: alcohol abuse/chronic liver disease, hypothyroidism
State the 3 main groups of causes of anaemia in infants + children
- Impaired RBC production inc. red cell aplasia + ineffective erytropoiesis
- Increased RBC destruction (haemolysis)
- Blood loss
State 4 causes of increased RBC destruction
- RBC membrane disorders: inherited spherocytosis
- RBC enzyme disorders: G6PD
- Haemoglobinopathies: SCA
- Immune [neonates]
State some common serious bacterial infections causing fever in children/infants
Sepsis Pneumonia Meningitis UTI Osteomyelitis
State some common less serious infections causing fever in children/infants
Otitis media
Tonsilitis
Lower RTIs
Gastroenteritis
What other infectious conditions can cause fever in children?
HIV
TB
Malaria
Typhoid
State 5 non-infectious causes of fever
AI/inflammatory disorders: SLE, JIA, Kawasaki’s disease, vasculitides
Malignancy: leukaemia, lymphoma
An infant under 3 months presents with a fever. What series of tests must you perform?
FULL SEPTIC SCREEN
What investigations are performed under a septic screen?
FBC U&Es Blood cultures Urine MC&S CXR Lumbar puncture
Why would you do a urine MC&S for a child with a fever?
RULE OUT UTI
Why might you do a blood gas in a child with a fever?
Indicate respiratory compromise + sepsis (acidosis)
What ABx would you commence in a neonate with suspected meningitis?
IV CEFTRIAXONE + AMOXICILLIN [listeria cover]
What ABx would you commence in an infant/child with suspected meningitis?
IV CEFTRIAXONE
What ABx would you commence in an infant >3months with suspected uncomplicated UTI ?
Trimethoprim or
Nitrofurantoin
What is a UTI?
Bacterial colonisation of the urinary tract
>10*5 CFU/ml of urine
What is the most common cause of UTI?
E.coli
State some other causative pathogens of UTI in children
Klebsiella
Proteus mirabilis [boys]
Pseudomonas [structural abnormality]
Strep.faecalis
What is the most common way for bacteria to colonise the UT?
Bowel flora ascend up the urethra
State some of the features of an atypical UTI
Sepsis/IV ABx No response to treatment within 48hrs Non-E.coli cause Increased creatinine/decreased GFR Poor urine flow Abdominal/bladder mass
Why are UTIs potentially significant in children?
High risk of recurrence
50% have structural abnormality
Long-term complications e.g. CKD
Acute illness
State 3 risk factors for UTI
Female
Previous UTI
Vesico-ureteric reflux
Anatomical abnormality
How do infants typically present with UTIs?
Non-specific symptoms
FEVER, vomiting, lethargy, irritability, poor feeding, offensive smelling urine, septicaemia
How do children typically present with UTIs?
Older the child, more specific the UTI symptoms Abdominal/loin pain Dysuria Frequency Haematuria Fever Foul smelling urine \+ non-specific symptoms
What is the screening investigation for a UTI?
Urine dipstick
What is the gold-standard screen for UTI?
Urine microscopy, culture + sensitivity with clean catch urine sample
What is the outcome if the dipstick is leucocyte esterase + nitrite positive?
Treat as UTI, commence ABx
What is the outcome if the dipstick is leucocyte esterase + nitrite negative ?
Unlikely to be UTI
What is the outcome if the dipstick is leucocyte esterase positive + nitrite negative?
Send urine sample for MC&S
What is the outcome if the dipstick is leucocyte esterase negative + nitrite positive?
Treat as UTI, commence ABx
Send urine sample for MC&S
What are the indications for further testing with an USS? What can you see from this?
<6 months old, atypical or recurrent UTI
Structural abnormalities + urinary obstruction
If abnormalities are found on the USS, what other investigations might be performed?
- Micturating Cystourethrogram (MCUG): illustrates vesicle-ureteric reflux
- DMSA: perform 3-6 months after UTI, illustrates renal scarring
What is the management of an infant <3months with a UTI?
Paediatric referral
IV Amoxicillin + Gentamycin (swap to PO when temperature decrease)
What is the management of an infant/child >3months with an uncomplicated UTI?
PO Trimethoprim/Nitrofurantoin
What is the management of a child > 3months with suspected acute pyelonephritis?
PO CEFALEXIN/CO-AMOXICLAV
What is croup?
Infectious paediatric emergency characterised by inflammation of the trachea + larynx. Mucosal inflammation + increased secretions
What is the most common cause of croup?
Parainfluenza
What cohort of PTs does croup often affect? During what time of year?
6months-6yo children
Spreads during autumn most commonly
Give an overview of the onset of croup
Onset over 1-2 days starting with prodromal phase:
- Nasal congestion + discharge)
- Fever (low-grade)
What are the 3 characteristic clinical features of croup?
BARKING COUGH
INSPIRATORY STRIDOR
HOARSE VOICE/CRY
What may indicate a case of mild croup is worsening?
Tachypnoea/dyspnoea
Chest recessions
Tachycardia
What may indicate a case of croup is very severe and potentially life-threatening?
Severe tachypnoea/dyspnoea
Cyanosis
Head bobbing
Bradycardia
A child presents with symptoms of croup. He has good air-entry and is alert. No recessions or stridor evident. How will you manage this PT?
PO DEXAMATHASONE
If PT improves, manage PT at home
A child presents with a barking cough, hoarse cry and severe chest recessions. He appears short of breath. You diagnose croup. How will you manage this PT?
Hospitalise PT
OXYGEN THERAPY
PO DEXAMETHASONE
If PT does not improve give NEBULISED ADRENALINE
What must you not do to a PT with acute upper AWs obstruction?
Examine throat
When might you consider intubation in a child with severe croup?
Severe respiratory distress e.g. cyanosis/head-bobbing/bradycardia/altered mental status
What is acute epiglottitis?
Rapidly progressive inflammation of the epiglottis resulting in respiratory obstruction
Paediatric emergency
What is the main cause of acute epiglottitis?
Haemophilus influenza type B (HiB)
Who does acute epiglottitis tend to affect?
PI: 1-6yo
Remember: can also affect adults
What are the main symptoms of epiglottitis?
Drooling
Dysphagia
Painful throat
Fever (high-grade)
State some of the signs you might expect in a PT with acute epiglottitis
TOXIC/VERY ILL DISTRESSED CHILD
Tripod position
Struggle to speak
Inspiratory stridor
What is mean by a tripod posture? What condition does it often present it?
Acute epiglottitis
PT sits upright, leaning forward with mouth open
A child presents drooling and unable to swallow or speak. He is in the classic “tripod position”. How do you manage him?
EMERGENCY, DO NOT DELAY TREATMENT
ITU + secure airway
Blood cultures
IV CEFTRIAXONE
A child with acute epiglottitis has two brothers. They have not been immunised against HiB. What might you give them as prophylaxis?
RIFAMPICIN
What is bronchiolitis?
Infection + subsequent inflammation of the bronchioles (lower RT)
Viral LRTI
What is the main cause of bronchiolitis? Compare this to croup
Bronchiolitis = RSV Croup = Parainfluenza
Who does bronchiolitis tend to affect?
Children < 2yo
PI: 3-6 months
Give an overview of the progression of symptoms in bronchiolitis
Day 1-2: coryzal/prodromal phase, virus has infects epithelia of upper respiratory tract
Day 3-5: symptoms + signs are worst at this time, virus has infected lower AW epithelia
Day 6: child will improve
State 3 risk factors for severe bronchiolitis
- Prematurity
- CF
- Heart/lung disease
- Immunodeficiency
Give an overview of the pathophysiology of bronchiolitis
Inflammation of SM+ mucus build up–> AW obstruction
Air diffuses into blood–> AW collapse
Air trapped by obstruction
What symptoms may a PT experience in the coryzal phase of bronchiolitis?
Fever (low-grade) Runny nose (rhinorrhoea)
3 days into bronchiolitis the RSV starts to colonise the lower AW. What symptoms would the PT experience?
Dry, sharp COUGH
DYSPNOEA
POOR FEEDING
What signs may a PT with bronchiolitis present with?
Tachypnoea Wheeze Inspiratory crackles Hyperinflation Respiratory distress
What is the main investigation used to diagnose bronchiolitis?
Nasal swab + PCR (nasopharyngeal secretions)
Give some indications for admitting a PT with bronchiolitis
- Oxygen sats <92%
- Apnoea
- Comorbidity: lung/heart disease, premature
- Severe respiratory distress
- Inadequate fluid intake
A 1yo girl presents with a dry cough and shortness of breath. They have chest recessions and nasal flaring. You suspect bronchiolitis + this is confirmed by nasal swab. How do you manage this PT?
SUPPORTIVE MANAGEMENT
- IV fluids
- NG feeds
- High-flow humidified oxygen
- CPAP (if respiratory failure)
What might you give to high risk PTs as prophylaxis against RSV?
IM PALIVIZUMAB
What is epilepsy?
Recurrent tendency to experience intermittent, spontaneous abnormal electrical activity in brain, manifested as seizures
What is generalised epilepsy?
Electrical discharge arises from both hemispheres
What is focal epilepsy?
Electrical discharge arises from one or part of one hemisphere
State the different types of generalised epilepsy
- Tonic clonic
- Absence
- Myoclonic
- Atonic
- Tonic
State the different types of focal epilepsy
- Simple: no loss of consciousness
2. Complex: loss of consciousness
Who might you expect to present with absent epilepsy? How would they present?
Children (4-10yo)
Suddenly cease activity + stare into space, child has no recall missed something
How might an individual with generalised tonic-clonic seizure present?
Tonic phase: suddenly become stiff, rigid + fall to floor
Clonic phase: generalised, bilateral muscle jerking
What other features may you want to establish to diagnose tonic clonic seizures?
Tongue biting
Eyes open
Loss of continence
Post-ictal confusion/drowsiness
How does juvenile myoclonic epilepsy present?
Typically in adolescence-adulthood
Sudden onset jerking of limb, trunk or face
“throwing cereal about in morning”
Often in morning
Who tends to present with West syndrome? How do they present?
West syndrome = epilepsy syndrome seen in very young (4-6 months)
Flexor spasms of head, neck + limbs followed by extension of arms
Spasms last 1-2 seconds + occur in clusters
How would you treat west syndrome (epilepsy)?
Corticosteroids
Vigabatrin
How is epilepsy diagnosed?
CLINICAL DIAGNOSIS: 2 or more unprovoked seizures >24hrs apart
What investigations might support a diagnosis of epilepsy?
EEG + video telemetry
CT head: important if neurological signs, focal seizures or to rule out underlying cause
What is 1st line anti-epileptic drug for generalised tonic clonic in children?
Valporate, Carbemazepine
What is 1st line anti-epileptic drug for absence seizures?
Valporate, Ethosuximide
What is 1st line anti-epileptic drug for myoclonic seizures?
Valporate
What is the 2nd line anti-epileptic medication for all generalised epilepsy?
Lamotrigine
State some 1st line medications for focal seizures in children
Valporate
Carbemazepine
Lamotrigine
A child is brought to A&E after having a seizure for 35 minutes with no sign of stopping. How do you manage the child initially?
ABCD
Check AW
Check glucose <3 give glucose
A child is brought to A&E after having a seizure for 35 minutes with no sign of stopping. You do not have IV access, what medication do you give? There is no response to this or second dose, what do you now give?
Either buccal midazolam or PR diazepam
IV phenytoin + PR paraldehyde in meantime
A child is brought to A&E after having a seizure for 35 minutes with no sign of stopping. You have IV access, what medication do you give?
IV LORAZEPAM
In a girl >12yo with abdominal pain, what test is mandatory?
Pregnancy test
What is the most common cause of appendicitis in children?
Lymphoid tissue hyperplasia–> Lumen of appendix obstructed
Describe the main symptom that a children with appendicitis will be experiencing
ABDOMINAL PAIN
Initially peri-umbilical + localises to RIF (McBurney’s point), constant + worsens, worse on movement
State two signs that may indicate appendicitis
McBurney’s sign: rebound tenderness
Guarding of RIF
Rovsing’s signs
Psoas sign
What two clinical features may indicate a perforated appendix?
High grade fever
Generalised guarding
What symptoms are expected in acute appendicitis?
Abdominal pain
N&V
Anorexia
Low-grade fever
How is appendicitis diagnosed?
Clinical diagnosis with history + examination
Support with lab studies
State two findings on blood results that would be expected in a child with appendicitis
Raised WCC (neutrophils) Raised CRP
You suspect a child has non-complicated appendicitis, how do you manage this child?
Appendicetomy + prophylactic ABx (IV Piperacillin/ Tazobactam 24hrs)
A child with suspected appendicitis develops a high-grade fever and generalised guarding. How might you manage this child?
Fluid resus, IV ABx
Appendicetomy + prophylactic IV ABx (5-10 days)
State some red flags for child with constipation
Failure to pass meconium in 1st 24hrs: CF/HD
Abdominal distension: HD
Failure to thrive/grow: coeliac disease, hypothyroidism
Lower limb neurology + urinary incontinence: lumbosacral pathology
State 4 clinical features of a child with constipation
Abdo pain/bloating Difficulty passing stool Infrequent passage Over-flow diarrhoea Involuntary soiling Decreased appetite Blood in stool (fissures)
What is encopresis? In what situation does it occur?
Involuntary defecation at age where continence expected
Occurs in chronic constipation
Why does encopresis occur in chronic constipation?
For 2 reasons:
- Faecal matter retained causing secondary overflow incontinence
- Large bolus of faeces difficult to pass, rectal dilatation + loss of awareness of emptying rectum
When a child presents with constipation, what are the key differential diagnosis to consider?
Hirschprung's disease Bowel obstruction Spinal cord compression Hypothyroidism Coeliac disease
A well-looking child presents with mild abdominal discomfort, loss of appetite and you palpate an abdominal mass in LIF on examination. What is the most likely diagnosis?
Idiopathic constipation
What is constipation?
Infrequent passage of stool associated with pain and difficulty/straining
State some factors that may increase a child’s risk of idiopathic constipation
Low fibre diet
Lack of mobility/exercise
FH of reduced colonic motility
A child presents with mild constipation and otherwise looks well. How will you manage them?
Encourage fluids Balanced diet (inc. fibre) Possibility maintenance laxative (polyethylene glycol)
A child has had chronic constipation and was tried for 2wks on movicol. What is the next treatment you would suggest?
Senna (stimulant laxative), this follows movical (stool softener)
If Senna + lactulose does not relieve a child of their constipation, what are the options?
Enema (+/- sedation) Manual evacuation (GA)
What is intussusception?
Invagination of proximal part of bowel into distal segment–> Bowel obstruction
What demographic of PTs does intussusception often affect?
2months- 2yo
Where is the most common place in the bowel for intussusception to occur?
Ileo-caecal valve
What is the classic presentation of intussusception?
Bilious vomiting + triad:
- Abdo pain
- Red-currant jelly stool
- Sausage-like abdominal mass
What is the gold-standard diagnosis for intussusception?
USS abdomen- target sign
Shows 2 concentric circles indicating 2 loops of bowel
Before any investigation, if you suspect intussusception, what must you do? If they are in shock e.g. hypovolaemic what do you do?
Secure IV access
IV fluids inc. 20ml/kg NaCl bolus
A patient has suspected intussusception, how do you manage them? They do not appear in shock
Secure IV access–> USS diagnosis–> IV fluids + ABx–> Surgery (insufflation or manual reduction)
State 3 complications of intussusception
Ischaemia + necrosis
Perforation
Peritonitis
Haemorrhage (hypovolaemic shock)
Give two classic signs seen in PT with intussusception
DRAWING UP OF LEGS
Pallor
What is the most common cause of gastroenteritis in infants/children?
Viruses specifically ROTAVIRUS
Explain how a PT with gastroenteritis may present
Sudden onset DIARRHOEA + VOMITING
Headaches, lethargy, weight loss, abdominal pain, blood stools, fever
What is the main aim of treatment in gastroenteritis?
Prevent or correct dehydration
How would you work out the degree of dehydration in a child with gastroenteritis?
Degree of weight loss indicates severity of dehydration
<5% loss = no clinically detectable dehydration
5-10% weight loss = clinical dehydration
>10% = shock, identify + correct without delay
Give 3 factors that put an infant at increased risk of dehydration
Low birth weight Diarrhoea > 6 times 24hrs Vomiting >3 times 24hrs Infants > 6 months Unable to tolerate fluids Malnutrition
What are the three types of dehydration?
- Hyponatraemic dehydration: greater net loss of Na+ than water, children drink loss of water
- Isonatraemic dehydration: loss of Na+ is proportional to water loss
- Hypernatraemic dehydration: water loss exceeds sodium loss, often due to insensible water loss
What is the problem with correcting hypernatraemic dehydration?
DO NOT REPLACE FLUIDS TOO FAST
Rapid decrease in Na+ osmolality–> Shift water into cerebral cells–> Cerebral oedema
At what rate should you be aiming to reduce plasma concentration of Na+ in hypernatraemic dehydration?
0.5mmol/L/hr over 48hrs
Under what’s conditions might you take a stool sample and culture in gastroenteritis?
- Sepsis
- Suspect unusual pathogen/travel abroad
- Blood/mucus in stool
- No improvement over 7 days
- Immunocompromised child
Give 3 clinical features of a patient with clinical dehydration
Appears unwell Lethargic/irritable Eyes sunken Tachycardic Urine output decreased
Give 3 clinical features of a patient with shock caused by dehydration
Cold extremities CRT > 2secs Dry mucosal membranes Pale, mottled skin Decreased level of consciousness
A 2 year old boy has developed sudden onset diarrhoea and vomiting over the last 48hrs. He looks reasonably well but his mum is concerned he is dehydrated. How do you manage this child assuming there is <5% weight loss? He has vomited 4 times in the past 24hrs
<5% weight loss–> No clinically detectable dehydration
Encourage oral intake of fluid
Vomiting >3 times in past 24hrs puts him at increased risk of dehydration so give ORAL REHYDRATION SOLUTION
What fluid deficit replacement amount do you give in a child who is clinically dehydrated but showing no signs of shock?
50ml/kg over 4hrs
What fluid deficit replacement amount do you give in a child who is showing signs of shock from dehydration?
100ml/kg over 4hrs
What is ulcerative colitis?
Chronic relapsing-remitting inflammatory disease of the bowel, characterised by involvement of colonic mucosa
State some macroscopic features of UC
- Mucosa looks inflamed + reddened, bleeds easily
- Ulcerations/pseudopolyps
- Begins at bowel + extends proximally
- Affects up to ileo-caecal valve
- Circumferential + continuous inflammation
State some microscopic features of UC
- Mucosal + sub-mucosal inflammation
- Decreased goblet cells
- Increased crypt abscesses
Who does ulcerative colitis typically present in?
Adolescents + young adults
State 3 important symptoms of ulcerative colitis
- BLOODY DIARRHOEA (+/-mucus)
- Abdominal pain (colicky, LIF)
- Faecal urgency
- Tenesmus: painful urge to pass stool even when rectum empty
Name 3 extra-intestinal features associated with ulcerative colitis
Arthritis
PSC
Uveitis
State some different types of ulcerative colitis
- Ulcerative proctitis: inflammation limited to rectum
- Left-sided colitis: inflammation does not extend proximally to splenic flexure
- Extensive colitis: spreads proximally to splenic flexure. Including pancolitis
What is the gold-standard investigation for suspected UC?
Colonoscopy + biopsy
Histology will show decreased goblet cells, increased crypt abscesses, ulceration + mucosal inflammation
State some other investigations that might indicate ulcerative colitis
Faecal calprotectin
+ve pANCA
Barium imaging
CT/MRI
What is the management for mild-moderate UC?
Mesalazine (used for remission and maintenance)
What treatment might you use in an adolescent with moderate-severe UC?
Oral prednisolone (only for remission, not maintenance)
State some immunomodulators that could be used in the maintenance of UC, or in treatment of resistant active disease
Azathioprine
Ciclosporin
Infliximab
What surgical options are there for ulcerative colitis?
Colectomy + ileostomy
Ileo-rectal pouch
What is toxic megacolon?
Complication of IBD whereby there is acute dilatation of the colon, can result in sepsis + perforation
What is Crohn’s disease?
Chronic inflammation of the GI tract characterised by transmural granulomatous inflammation, any where from mouth to anus
State some macroscopic features of Crohn’s disease
Skip lesions (discontinuous)
Cobblestone appearance: ulcers and tissues in mucosa
Thickened/narrowed bowel
State some microscopic features of Crohn’s disease
Non-caseating granulomas
Transmural inflammation
Normal glands + goblet cells
Less crypt abscesses
What is a volvulus? Which types if most common in infants/children?
Twisting of intestine and surrounding mesentery on its axis
Midgut volvulus most common in children due to malrotation during development
A volvulus causes two major problems, what are they?
- Bowel ischaemia: twisting of mesentery containing blood vessels compromises blood supply
- Bowel obstruction: mechanical obstruction as bowel twists on itself
Give 3 key clinical features a PT with a midgut volvulus might present with
- Bilious vomiting
- Tender abdomen
- Distended abdomen
- Constipation
- Generally unwell/irritable
You suspect a child has a midgut volvulus, they are constipation and having been vomiting green liquid. What investigations will confirm this?
AXR: will show bowel obstruction
Barium contrast: show dilatation of intestine e.g. duodenum
State 5 differential diagnosis for bilious vomiting
- Intussusception
- Hirschprung’s disease
- Malrotation + volvulus
- Duodenal/intestinal atresia
- Meconium ileum
- Ano-rectal malformation
How will you manage suspected volvulus?
SURGICAL EMERGENCY
Aggressive fluid resuscitation, NG drainage + IV ABx
Laparotomy: Ladd’s procedure to untwist volvulus
What is the main complication of a midgut volvulus?
Intestinal ischaemia + infarction–> Sepsis
Perforation + peritonitis follow–> Death