Paediatrics 3 Flashcards
What is Klinefelter syndrome?
Occurs when a male has an Additional X chromosome making them 47 XXY.
Rarely they can have even more chromosomes such as 48 XXXY or 49 XXXXY
Extra X-chromosome material is responsible for testicular hyalinization and fibrosis, leading to primary gonadal failure that often evolves through adolescence and young adulthood
What is the presentation of Klinefelter syndrome?
Will appear as normal males until puberty where they will develop features of the condition such as:
- Taller height
- Wider hips
- Gynaecomastia
- Weaker muscles
- Smaller testicles
- Reduced libido
- Shyness
- Infertility
- Learning difficulties
What are the management options for Klinefelter syndrome?
- Testosterone injections
- Advanced IVF techniques
- Breast reduction surgery
What is there an increased risk of with Klinefelter syndrome?
- Breast cancer
- Osteoporosis
- Diabetes
- Anxiety and depression
What is Down’s syndrome?
Down’s Syndrome is caused by three copies of chromosome 21. It is also called trisomy 21. It gives characteristic dysmorphic features and is associated with a number of associated conditions.
What are the dysmorphic features of Down’s syndrome/
- Hypotonia
- Brachycephaly
- Short neck
- Short stature
- Flattened face and nose
- Prominent epicanthic folds
- Upward sloping palpebral fissures
- Single palmar crease
What are the complications of Down’s syndrome?
- Learning disability
- Recurrent otitis media
- Deafness
- Visual problems
- Hypothyroidism
- Cardiac defects: Affect 1 in 3, particularly ASD, VSD, patent ductus arteriosus and tetralogy of Fallot
- Leukaemia
- Dementia
What are some follow up investigations that are important for children with Down’s syndrome?
Regular thyroid checks (2 yearly)
Echocardiogram to diagnose cardiac defects
Regular audiometry for hearing impairment
Regular eye checks
What is turner syndrome?
Occurs when a female has a single X chromosome making them 45XO
What are the features of turner syndrome?
- Short stature
- Webbed neck
- High arching palate
- Downward sloping eyes
- Widely space nipples
- cubitus valgus
- Undeveloped ovaries with reduced function
- Late or incomplete puberty
- Most women are infertile
What is cubitus valgus?
An abnormal feature of the elbow.
When the arm is extended downwards with the palms facing forwards the angle of the forearm at the angle of the forearm at the elbow is exaggerated
What are the 3 classic features of turner syndrome?
- Webbed neck
- Short stature
- Widely spaced nipples
What are some conditions associated with turner syndrome?
Recurrent otitis media
Recurrent urinary tract infections
Coarctation of the aorta, Aortic stenosis.
Aortic dissection
Hypothyroidism
Hypertension
Obesity
Diabetes
Osteoporosis
Various specific learning disabilities
What is the management of turner syndrome?
- Growth hormone
- Oestrogen and progesterone
- Fertility treatment
What is Noonan syndrome?
It is an autosomal dominant condition that has a number of different genes that can cause it
What are some features of Noonan syndrome?
Short stature
Broad forehead
Downward sloping eyes with ptosis
Hypertelorism (wide space between the eyes)
Prominent nasolabial folds
Low set ears
Webbed neck
Widely spaced nipples
What are some conditions associated with Noonan syndrome?
- Congenital heart disease, particularly pulmonary valve stenosis, HOCM and ASD
- Cryptorchidism
- Learning disability
- Bleeding disorders
- Lymphoedema
- Increased risk of leukaemia and neuroblastoma
What is a key difference between Noonan and Turner?
Fertility is preserved in Noonan
What causes Edwards syndrome?
Trisomy 18
What is the prognosis of Edwards syndrome?
Many of those affected die before birth. Some studies suggest that more babies that survive to birth are female. Survival beyond a year of life is around 5–10%.
What are the features of Edwards syndrome?
Low birthweight
* Prominent occiput
* Small mouth and chin
* Short sternum
* Flexed, overlapping fingers
* ‘Rocker-bottom’ feet
* Cardiac and renal
malformations
What is Patau syndrome?
Trisomy 13
What is seen in Patau syndrome?
Nervous system
Intellectual disability and motor disorder
Microcephaly
Polydactyl
Low set ears
Rocker bottom feet
Cleft palate
Heart defects
What is the prognosis of Patau syndrome?
Approximately 90% of infants with Patau syndrome die within the first year of life.[8] Those children who do survive past 1 year of life are typically severely disabled with intellectual disability, seizures, and psychomotor issues
What is fragile X syndrome?
It is caused by the FMR1 gene on the ** X chromosome** which plays a role in the cognitive development of the brain
What inheritance pattern is Fragile X?
X-linked but unclear whether it is dominant or recessive.
Males are always affected but it varies how much females are affected
What are the features of Fragile X?
Usually presents with a delay in speech and language development
- Intellectual disability
- Long narrow face
- Large ears
- Large testicles
- Hypermobile joints
- ADHD
- Autism
- Seizures
What is cystic fibrosis?
An inherited autosomal recessive multi-system disease affecting the mucus glands
A mutation on what gene causes CF?
cystic fibrosis transmembrane conductance regulatory gene on chromosome 7
How does a mutation to the CFTR gene cause disease?
- The CFTR protein gets misfolded and can’t migrate from the RER to the cell membrane
- The CFTR is a channel protein that pumps chloride ions into various secretions helping to thin them out meaning secretions are left overly thick
How does CF cause respiratory problems?
- Results in dry airways and impaired mucociliary clearance
- The low volume thick airway secretions result in reduced airway clearance increasing chances of infection and this chronic inflammation can lead to bronchiectasis
What are the GI problems associated with CF?
- Thickened secretions within small and large bowel can make it difficult to pass stools resulting in bowel obstruction
What are the pancreatic problems associated with CF?
Thick pancreatic and bile secretions can block the pancreatic ducts resulting in a lack of digestive enzymes this can also result in pancreatitis and diabetes
What are the liver problems associated with CF?
Thickened biliary secretions may block the bile ducts resulting in liver fibrosis and cirrhosis
What are some other problems associated with CF?
- Can result in pulmonary hypertension leading to right sided heart failure
- In males there is bilateral absence of vas deferens so it means there is male infertility
What if often the first sign of CF in a baby?
meconium ileus
What is meconium ileus?
- In babies the first stool passed is called the meconium and it is black and sticky and should be passed within 48 hours
- In babies with CF the meconium does not pass as it is too sticky so it causes bowel obstruction occurs in 20% of babies with CF
What are some signs of CF?
- Low weight
- Nasal polyps
- Finger clubbing
- Crackles and wheezes
- Abdominal distension
What are the symptoms of CF?
- Chronic cough
- Thick sputum production
- Recurrent respiratory infections
- Loose, greasy stools (steatorrhea) due to a lack of fat digesting lipase enzymes
- Abdominal pain and bloating
- Poor weight and height gain (failure to thrive)
-Parents may report the child tastes particularlysaltywhen they kiss them, due to the concentrated salt in the sweat
When is CF most often diagnosed?
- It is found during the heel-prick/Guthrie test which screens for CF in babies by looking for serum immunoreactivity trypsinogen
What is the gold standard test for CF?
The sweat test
What is the sweat test?
test for CF
- Pilocarpine is applied to the skin and electrodes are placed either side of the patch with small current to cause skin to sweat
- The sweat is absorbed and sent to lab for testing a diagnostic test of chloride concentration above **60 mmol/l is diagnostic
What are common microbial colonisers in CF?
- Staphylococcus aureus- patients take long term prophylactic flucloxacillin
- Pseudomonas aeruginosa- can be harder to treat and worsen the prognosis
What is the management for the respiratory symptoms of CF?
- Chest physiotherapy at least twice a day to remove mucus
- Exercise
- Salbutamol
- Nebulised DNase (dornase alfa wolf) an enzyme that breaks down DNA material in respiratory secretions
- Nebulised hypertonic saline
What is the treatment for the GI symptoms of CF?
- CREON tablets helps to digest fats in patients with pancreatic insufficiency (missing lipase)
- High calorie diet to make up for malabsorption and calories needed for respiratory effort
What is the prognosis for CF?
. Life expectancy is improving and currently the cystic fibrosis trust gives a median life expectancy of 47 years.
- 90% of patients with CF develop pancreatic insufficiency
- 50% of adults with CF develop cystic fibrosis-related diabetes and require treatment with insulin
- 30% of adults with CF develop liver disease
Most males are infertile due to absent vas deferens
what is the new miracle cure for CF?
Kaftrio, described by patient groups as a ‘revolutionary drug’, is a triple combination treatment combining three drugs which perform different functions – ivacaftor, tezacaftor and elexacaftor – and tackles the underlying causes of the disease, by helping the lungs work effectively.
What is muscular dystrophy?
An umbrella term for genetic conditions that cause gradual weakening and wasting of muscles
What is DMD?
It is caused by a mutation (out of frame deletion) of the gene for dystrophin
Dystrophin is responsible for connecting the actin cytoskeleton of each muscle fibre to the underlying basal lamina
The absence of dystrophin means excess calcium penetrates the cell membrane leading to myofibril necrosis
What is the inheritance of DMD?
X linked recessive condition
Describe the pathophysiology of DMD?
Muscles are not protected from being broken down by enzymes
Therefore DMD you get progressive wasting and weakness of muscle as they are broken down
What cardiovascular conditions are associated with DMD?
Dilated cardiomyopathy
What are the symptoms of DMD?
Child struggles to get up from lying down (GOWER’s sign)
Skeletal deformities
What is raised in people with DMD?
Creatinine kinase
Check this in any boy not walking by 18 months
What is Gower’s sign?
Children with proximal muscle weakness use a specific technique to stand up from a lying position
To stand up, they get onto their hands and knees, then push their hips up and backwards like the “downward dog” yoga pose. They then shift their weight backwards and transfer their hands to their knees. Whilst keeping their legs mostly straight they walk their hands up their legs to get their upper body erect. This is because the muscles around the pelvis are not strong enough to get their upper body erect without the help of their arms.
What is the presentation of DMD?
Boys present around 3-5 years with weakness in the muscles around the pelvis
What is the management and life expectancy of DMD?
. They are usually wheelchair bound by the time they become a teenager. They have a life expectance of around 25 – 35 years with good management of the cardiac and respiratory complications.
Oral steroids have been shown to slow the progression of muscle weakness by as much as two years.
Creatine supplementation can give a slight improvement in muscle strength. Genetic trials are ongoing.
What is Becker’s muscular dystrophy?
Becker’s muscular dystrophy is very similar to DMD, however the dystrophin gene is less severely affected and maintains some of its function.
The clinical course is less predictable than DMD. Symptoms only start to appear around 8 – 12 years. Some patient require wheelchairs in their late 20s or 30s . Others able to walk with assistance into later adulthood. Management is similar to DMD
What is myotonic dystrohpy?
Myotonic dystrophy is a genetic disorder that usually presents in adulthood. Typical features are:
Progressive muscle weakness
Prolonged muscle contractions
Cataracts
Cardiac arrhythmias
What is the key feature of myotonic dystrophy?
The key feature of myotonic dystrophy to remember is the prolonged muscle contraction. This may present in exams with a patient that is unable to let go after shaking someone’s hand, or unable to release their grip on a doorknob after opening a door.
What is Angelman syndrome?
A genetic condition caused by the loss of function of the UBE3A gene specifically the copy inherited from the mother
What chromosome is affected in Angelman syndrome?
15
What are the features of Angelman syndrome?
- Delayed development
- Severe delay or absence of speech development
- Coordination and balance problems (ataxia)
- Fascination with water
- Happy demeanour
- Inappropriate laughter
- Hand flapping
- Abnormal sleep patterns
- Epilepsy
- Attention-deficit hyperactivity disorder
- Dysmorphic features
- Microcephaly
- Fair skin, light hair and blue eyes
- Wide mouth with widely spaced teeth
What are the key features of Angelman syndrome?
Water fascination, happy demeanour and widely spaced teeth
What is Prader-Willi Syndrome?
a genetic condition caused by the loss of functional genes on the proximal arm of the chromosome 15 inherited from the father.
This can be due to a deletion of this portion of the chromosome, or when both copies of chromosome 15 are inherited from the mother.
What are the features of Prader-Willi syndrome?
Constant insatiable hunger that leads to obesity
Poor muscle tone as an infant (hypotonia)
Mild-moderate learning disability
Hypogonadism
Fairer, soft skin that is prone to bruising
Mental health problems, particularly anxiety
Dysmorphic features
Narrow forehead
Almond shaped eyes
What is the management of Prader-Willi syndrome?
Growth hormone is indicated aimed at improving muscle development and body composition
What is the genetic mutation type of Angelman’s and PWS?
Imprinting
What is William syndrome?
William syndrome is caused by a deletion of genetic material on one copy of chromosome 7, resulting in the person only having a single copy of the genes on this deleted region (on the other chromosome 7). It usually the result of a random deletion around conception, rather than being inherited from an affected parent.
What chromosome is affected in William syndrome?
7
What are the features of William syndrome?
Broad forehead
Starburst eyes (a star-like pattern on the iris)
Flattened nasal bridge
Long philtrum
Wide mouth with widely spaced teeth
Small chin
Very sociable trusting personality
Mild learning disability
What are the key features of William syndrome?
- Very sociable personality
- Starburst eyes
- Wide mouth
- Big smile
What are some associated conditions of William syndrome?
- Supravalvular aortic stenosis (narrowing just above the aortic valve)
- ADHD
- Hypertension
- Hypercalcaemia
What is osteogenesis imperfecta
A inherited condition that leads to bone weakness in children.
It is due to a defect in type 1 collagen genes
What is the inheritance of osteogenesis imperfecta?
Inheritance is Autosomal Dominate in 90%
There are 8 types of osteogenesis imperfecta depending on the underlying genetic mutation, and they vary in their severity. Type I is most common
What is the presentation of osteogenesis imperfecta?
It presents with recurrent and inappropriate fractures
- Hypermobility
- Blue/grey sclera
- Triangular face
- Short stature
- Deafness
- Dental problems
- Bone deformities
- Joint and bone pain
What are some tests for OGI?
- Genetic testing
- Biochemistry: normal/increased alkaline phosphatase (ALP).
Xrays to diagnose fractures and bone deformities
- Biochemistry: normal/increased alkaline phosphatase (ALP).
- Bone biopsy: histology—increased Haversian canal + osteocyte lacunae
diameters, increased cell numbers.
It is however a clinical diagnosis
What is the classification system for OGI called?
The silence classification
What are the medical treatments of OGI?
Bisphosphates
Vit D supplementation
What is Ricketts?
A condition affecting children where there is defective bone mineralisation causing soft and deformed bones
What causes Ricketts?
It is caused by a deficiency in Vit D or Calcium
There is a rare form of rickets caused by genetic defects that result in low phosphate in the blood
This is called hereditary hypophosphataemic rickets. The most common form is x-linked dominant, however it also has other modes of inheritance.
Describe the pathophysiology of rickets
Vit D is a hormone created by cholesterol by the skin in response to UV radiation. A standard diet contains inadequate levels
Patients with malabsorption disorders are more likely to be deficient as well as people with CKD as kidneys are needed to activate Vit D
Vit D is essential in calcium and phosphate absorption from the intestines and kidneys it is also important for regulating bone turnover and promoting bone reabsorption
Low levels of Vit D leads to lack of calcium and phosphate where results in defective bone mineralisation.
What is the effect of low calcium levels?
Low calcium causes a secondary hyperparathyroidism as the parathyroid gland tries to raise the calcium level by secreting parathyroid hormone.
Parathyroid hormone stimulates increased reabsorption of calcium from the bones. This causes further problems with bone mineralisation.
What are some risk factors for Rickets?
- Darker skin
- Low exposure to sunlight
- Poor diet
- Colder climate
What are the of Rickets?
- Lethargy
- Bone pain
- Swollen wrists
- Bone deformity
- Por growth
- Dental problems
- Muscle weakness
- Pathological fractures
What are some signs of Rickets (bone deformities)?
Bowing of the legs, where the legs curve outwards
Knock knees, where the legs curve inwards
Rachitic rosary, where the ends of the ribs expand at the costochondral junctions, causing lumps along the chest
Craniotabes, which is a soft skull, with delayed closure of the sutures and frontal bossing
Delayed teeth with under-development of the enamel
What are the investigations for Rickets?
Serum 25-hydrixyvitamin D is the lab test for vitamin D. A result of less than 25 nmol/L establishes a diagnosis vitamin D deficiency, which can lead to rickets.
- Serum calcium
- Serum phosphate
- Serum ALP may be high
- PTH may be high
What is needed for a diagnosis of Rickets?
X-ray will show osteopenia
What other tests will be performed on someone with Rickets?
Full blood count and ferritin, for iron deficiency anaemia
Inflammatory markers such as ESR and CRP, for inflammatory conditions
Kidney function tests, for kidney disease
Liver function tests, for liver pathology
Thyroid function tests, for hypothyroidism
Malabsorption screen such as anti-TTG antibodies, for coeliac disease
Autoimmune and rheumatoid tests, for inflammatory autoimmune conditions
What is the management for rickets?
Prevention is the best management breastfed babies are at higher risk. Therefore all breastfeeding women and children should take a vitamin D supplement
Children with vitamin D deficiency can be treated with vitamin D (ergocalciferol). The doses for treatment of vitamin D deficiency depend on the age (see the BNF). The dose for children between 6 months and 12 years is 6,000 IU per day for 8 – 12 weeks.
Children with features of rickets should be referred to a paediatrician. Vitamin D and calcium supplementation is used to treat rickets.
What is transient synovitis?
It sometimes is referred to as irritable hip. It is caused by irritation and inflammation in the synovial membrane
It is the most common cause of hip pain in children between 3-10 years
What is the presentation of transient synovitis?
It often occurs within a few week of a viral illness often a respiratory tract infection symptoms include:
- Limp
- Refusal to bear weight
- Groin or hip pain
- Mild to low grade temperature
Children with transient synovitis should be otherwise well. They should have normal paediatric observations and no signs of systemic illness. When other signs are present, consider alternative diagnoses.
What is the management of transient synovitis?
Treat with simple analgesia.
The challenge is to establish the correct diagnosis and exclude other pathology.
How should transient synovitis be treated?
Children aged 3-9 can be managed in primary care if the limp is present for less than 48 hours and they are otherwise well.
However they need safety net advice to attend A&E if symptoms get worse or they develop a fever.
There should be follow up at 48 hours and 1 week
What is the prognosis for transient synovitis?
Typically there is a significant improvement in symptoms after 24 – 48 hours. Symptoms fully resolve within 1 – 2 weeks without any lasting problems. Transient synovitis may recur in around 20% of patients.
What is the most common age for septic arthritis to occur and what is the mortality rate?
Most common age is under 4
Mortality is 10%
What is the presentation of septic arthritis?
It often affects a single joint which is often a knee or hip
- Hot red and swollen joint
- Refusing to bear weight
- Stiffness and reduced range of motion
- Systemic symptoms such as fever
What is the most common cause of Septic arthritis?
Staphylococcus aureus
What are some other bacteria that can cause SA?
Neisseria gonorrhoea (gonococcus) in sexually active teenagers
Group A streptococcus (Streptococcus pyogenes)
Haemophilus influenza
Escherichia coli (E. coli)
What is the Criteria seen in septic arthritis?
Kochers Criteria
T>38.5
CRP>20
ESR>40
WCC>12
Cannot weight bear
3/4 = septic joint.
What are some differentials of SA?
Transient sinovitis
Perthes disease
Slipped upper femoral epiphysis
Juvenile idiopathic arthritis
What are the investigations for SA?
- Have a low threshold for treating it until it has been excluded with examination of the joint fluid
- The joint should be aspirated prior to giving Abx. Send the sample for gram staining, crystal microscopy, culture and antibiotic sensitivities
What is the treatment for SA?
- Empirical IV Abx should be given until microbial sensitives are known. They should be continued for 3-6 weeks
-
Empirical therapy: flucloxacillin is first-line
- Penicillin allergy: clindamycin
- Patients may require surgical drainage and washout of the joint
What is osteomyelitis?
An infection in the bone and bone marrow.
What bones are most commonly affected bones in OM?
The metaphysis of long bones. The most common cause is staphylococcus aureus
What are the risk factors for OM?
More common in boys and children under 10:
- Open bone fracture
- Surgery
- Immunocompromised
- Sickle cell anaemia
- HIV
- TB
What is the presentation of OM?
An acutely unwell child or more chronically subtle signs and symptoms such as:
- Refusing to weight bear
- Pain
- Swelling
- Tenderness
They may be afebrile or have a low grade fever
What are the investigations for OM?
X-rays are often the initial investigation but can be normal
MRI is the best for establishing a diagnosis
What is the treatment for Osteomyelitis?
> 3 months old - IV cefuroxime (to cover for loads of stuff) 6 months, switch to fluclox when ready
What is Perthes disease?
It involves disruption of blood flow to the femoral head causing Avascular necrosis of the bone
What is the pathophysiology of Perthes diease?
It affects the epiphysis of the femur which is the bone distal to the growth plates
It is described as idiopathic meaning there is no clear cause of it. One theory suggests that repeated mechanical stress to the epiphysis may interrupt the blood supply.
Overtime there is revascularisation and healing of the femoral head. There is remodelling of the bone as it heals.
What is the main complication of Perthes disease?
A soft a deformed femoral head leading to early hip OA.
This leads to an artificial hip replacement in 5% of patients
What is the common age of presentation of Perthes disease?
- Most common between 5-8 and more common in boys 5:1 ratio
What is the presentation of Perthes disease?
- Pain in the hip or groin
- Limp
- Restricted hip movements
- Referred pain to the knee
There will be no history of trauma if there is minor trauma think about slipped upper femoral epiphysis, particularly in older children.
What are the investigations for Perthes disease?
X-ray (can be normal)
Blood tests are typically normal, particularly inflammatory markers that are used to exclude other causes
Technetium bone scan
MRI scan
What is the management of Perthes disease?
Initial management in younger and less severe disease is conservative. The aim of ,management to maintain a healthy position and alignment in the joint and reduce the risk of damage or deformity to the femoral head. This is with:
Bed rest
Traction
Crutches
Analgesia
Physiotherapy is used to retain the range of movement in the muscles and joints without putting excess stress on the bone.
Regular xrays are used to assess healing.
Surgery may be used in severe cases, older children or those that are not healing. The aim is to improve the alignment and function of the femoral head and hip.
Prognosis is best in those under 6
What is Slipped upper femoral epiphysis (SUFE)?
Where the head of the femur is displaced along the growth plate
It is more common in boys and presents aged 8-15
Average age is 12 in boys and 11 in girls
What is a risk factor for SUFE?
Obesity
What is the typical presentation of SUFE?
An obese male undergrowing a growth spurt. There may be history of minor trauma that triggers the onset of symptoms
- Hip, groin, thigh or knee pain
- Restricted range of movement
- Painful limp
- Restricted movement in the hip
What position will patients keep their hips in with SUFE?
External rotation
There will be restricted internal rotation of the hip
What is the investigation of choice for SUFE?
X-ray
Blood tests are normal, particularly inflammatory markers used to exclude other causes of joint pain
Technetium bone scan
CT scan
MRI scan
What is the management of SUFE?
Surgery to return the femoral head to the correct place
What is a discoid meniscus?
Congenital anomaly of the knee found in 3% of the population typically affecting the lateral meniscus
Discoid meniscus is thickened and has a fuller crescent shape and does not taper as much towards the centre of the joint and is shaped like a disc
What can having a discoid meniscus lead to??
The thickness of the meniscus is The thickness of the meniscus, its diminished vascular blood supply, and in some instances, weak capsular attachment, makes it more prone to tears compared to a normal meniscus.
a tear of the meniscus can result in pain, swelling, and snapping in the affected knee
What is the best way to diagnose a torn meniscus?
An X-ray study would be done to rule out any bony pathology such as a fracture. Since it is difficult to diagnose meniscal anomalies with X-ray, an MRI would be necessary to visualize the discoid meniscus.
What is Osgood-Schlatter disease?
Caused by inflammation at the tibial tuberosity where the patella ligament inserts
What age does Osgood-Schlatter disease present?
10-15 and is more common in boys
What is the pathophysiology of Osgood-Schlatter disease?
Stress form running, jumping and other movements at the same time as growth in the epiphyseal plate results in inflammation of tibial epiphyseal plate
There are multiple small avulsion fractures where the patella ligament pulls away tiny pieces of the bone causing a visible lump below the knee
What is the presentation of Osgood-Schlatter disease?
Osgood-Schlatter disease presents with a gradual onset of symptoms:
Visible or palpable hard and tender lump at the tibial tuberosity
Pain in the anterior aspect of the knee
The pain is exacerbated by physical activity, kneeling and on extension of the knee
What is the management of Osgood-Schlatter disease?
Initial management focuses on reducing the pain and inflammation.
Reduction in physical activity
Ice
NSAIDS (ibuprofen) for symptomatic relief
Once symptoms settle, stretching and physiotherapy can be used to strengthen the joint and improve function.
What is a complication of Osgood-Schlatter disease?
A rare complication is a full avulsion fracture, where the tibial tuberosity is separated from the rest of the tibia. This usually requires surgical intervention.
What is developmental dysplasia of the hip (DDH)?
A condition where there is a structural abnormality in the hips caused by the abnormal development of the Fetal bones during pregnancy
This leads to instability in the hips leading them prone to dislocation and subluxation.
What are some of the affects of DDH in later life?
- Weakness
-Recurrent subluxation and dislocation - Abnormal gait
- Early degenerative changes
What are the risk factors for DDH/
- Family history
- Breech presentation from 36 weeks onwards
- Breech presentation at birth for 28 weeks onwards
- Multiple pregnancy
When screening for DDH?
It is screened for at birth and the 6-8 week check.
What findings may suggest DDH on an exam?
Different leg lengths
Restricted hip abduction on one side
Significant bilateral restriction in abduction
Difference in the knee level when the hips are flexed
Clunking of the hips on special tests
What are the two special tests for DDH?
Ortolani test
Barlow test