Paediatrics Flashcards
What is the usual abnormality in Down’s syndrome and how would you test for it?
Trisomy 21
Antenatal - amniocentesis & chorionic villous sampling
Postnatal - genetic testing
What are some features of Down’s syndrome?
Small mouth Big tongue Flat occiput Epicanthic folds Upward slanting palpebral fissures Small ears Single palmar crease Obesity Short stature Short neck
What congenital abnormalities are associated with Down’s syndrome?
Congenital heart disease - Tetralogy of Fallot, ASD, VSD, AVSD, PDA Subglottic stenosis Duodenal atresia Hirschprung’s disease Pyloric stenosis Meckel’s diverticula Imperforate anus
What haematological malignancy has a higher incidence in Down’s syndrome?
AML
What are 2 common spinal abnormalities in Down’s?
Atlanto-axial instability
Cervical spondylosis
What features of Down’s syndrome are relevant to the anaesthetist?
Craniofacial abnormalities OSA Small mouth Macroglossia Micrognathia Short neck Adenotonsillar hypertrophy
How do you treat a cyanotic spell from ToF?
Administer O2
Console child in knee-chest position
Correct hypoglycaemia/hypothermia/arrhythmia
Anything that increases SVR and corrects hypoxia/acidaemia
Opioids/ketamine/midazolam - decrease stress/hypercapnoea; may cause decreased SVR
What is the physiology behind a cyanotic spell in ToF?
Decreased SVR or increased PVR
R to L shunt through VSD
Decreased PaO2/increased PaCO2/decreased pH
Tachypnoea
Increased negative intrathoracic pressure
Increased venous return
Increased R to L shunt
What is the circulating volume of a neonate?
85-90ml/kg
What is the total body water percentage of a neonate?
75-80% water (with proportionally more ECF than adults)
GFR is relatively low - caution with renally excreted drugs
Adults = 60-65% water
What is the acronym for paediatric critical care transfers?
ACCEPT: A - Assessment C - Control C - Communication E - Evaluation P - Preparation & Packaging T - Transportation
What are the RESPIRATORY differences between a neonate and an adult?
Diaphragmatic ventilation
Diaphragm easily splinted by organs
Lower FRC
Rate dependent minute ventilation, unable to increase Vt
Respiratory muscles easily fatigued - Type I fibres
Lower number of alveoli
Closing volume > FRC so greater risk of airway collapse
What are the CARDIOVASCULAR differences between a neonate and an adult?
CO is rate dependent Fixed SV Less compliant myocardium Dominant parasympathetic tone Higher blood volume per kg Transitional circulation
Outline the pathophysiology of laryngospasm
- Stimulus of vocal cords during inadequate anaesthesia
- Afferent limb: sensory fibres from INTERNAL branch of SUPERIOR laryngeal nerve to vagus
- Efferent limb: motor response from RECURRENT laryngeal nerve from vagus nerve
- 3 intrinsic muscles - lateral cricoarytenoids, thyroarytenoids and cricoarytenoids stimulated
- Adduction of cords
What are the causes of seizures in children?
Epilepsy Hypoglycaemia Intracranial pathology - tumour, meningitis, haemorrhage Non-accidental injury Poisoning Fever (in 6 months-6years old)