Paediatrics Flashcards

1
Q

What is the usual abnormality in Down’s syndrome and how would you test for it?

A

Trisomy 21

Antenatal - amniocentesis & chorionic villous sampling
Postnatal - genetic testing

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2
Q

What are some features of Down’s syndrome?

A
Small mouth
Big tongue
Flat occiput
Epicanthic folds
Upward slanting palpebral fissures
Small ears
Single palmar crease
Obesity
Short stature
Short neck
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3
Q

What congenital abnormalities are associated with Down’s syndrome?

A
Congenital heart disease - Tetralogy of Fallot, ASD, VSD, AVSD, PDA
Subglottic stenosis
Duodenal atresia
Hirschprung’s disease
Pyloric stenosis
Meckel’s diverticula
Imperforate anus
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4
Q

What haematological malignancy has a higher incidence in Down’s syndrome?

A

AML

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5
Q

What are 2 common spinal abnormalities in Down’s?

A

Atlanto-axial instability

Cervical spondylosis

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6
Q

What features of Down’s syndrome are relevant to the anaesthetist?

A
Craniofacial abnormalities
OSA
Small mouth
Macroglossia
Micrognathia
Short neck
Adenotonsillar hypertrophy
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7
Q

How do you treat a cyanotic spell from ToF?

A

Administer O2
Console child in knee-chest position
Correct hypoglycaemia/hypothermia/arrhythmia

Anything that increases SVR and corrects hypoxia/acidaemia
Opioids/ketamine/midazolam - decrease stress/hypercapnoea; may cause decreased SVR

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8
Q

What is the physiology behind a cyanotic spell in ToF?

A

Decreased SVR or increased PVR
R to L shunt through VSD
Decreased PaO2/increased PaCO2/decreased pH
Tachypnoea
Increased negative intrathoracic pressure
Increased venous return
Increased R to L shunt

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9
Q

What is the circulating volume of a neonate?

A

85-90ml/kg

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10
Q

What is the total body water percentage of a neonate?

A

75-80% water (with proportionally more ECF than adults)
GFR is relatively low - caution with renally excreted drugs

Adults = 60-65% water

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11
Q

What is the acronym for paediatric critical care transfers?

A
ACCEPT:
A - Assessment
C - Control
C - Communication
E - Evaluation
P - Preparation & Packaging
T - Transportation
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12
Q

What are the RESPIRATORY differences between a neonate and an adult?

A

Diaphragmatic ventilation
Diaphragm easily splinted by organs
Lower FRC
Rate dependent minute ventilation, unable to increase Vt
Respiratory muscles easily fatigued - Type I fibres
Lower number of alveoli
Closing volume > FRC so greater risk of airway collapse

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13
Q

What are the CARDIOVASCULAR differences between a neonate and an adult?

A
CO is rate dependent
Fixed SV
Less compliant myocardium
Dominant parasympathetic tone
Higher blood volume per kg
Transitional circulation
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14
Q

Outline the pathophysiology of laryngospasm

A
  • Stimulus of vocal cords during inadequate anaesthesia
  • Afferent limb: sensory fibres from INTERNAL branch of SUPERIOR laryngeal nerve to vagus
  • Efferent limb: motor response from RECURRENT laryngeal nerve from vagus nerve
  • 3 intrinsic muscles - lateral cricoarytenoids, thyroarytenoids and cricoarytenoids stimulated
  • Adduction of cords
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15
Q

What are the causes of seizures in children?

A
Epilepsy
Hypoglycaemia
Intracranial pathology - tumour, meningitis, haemorrhage
Non-accidental injury
Poisoning
Fever (in 6 months-6years old)
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16
Q

What are the features of an innocent murmur in a child?

A

Soft
Early systolic
Varies with position
No abnormal signs/symptoms/normal milestones achieved

17
Q

What are the anaesthetic considerations for pyloric stenosis surgery/patients?

A
  • Medical emergency (not surgical)
  • Correction of volume deficit, electrolyte and acid-base abnormalities with chloride containing fluid (e.g. 20ml/kg 0.9% NaCl followed by 5% Dextrose with 20mmol KCl at 1-1.5 x maintenance)
  • Require adequate UO and normal Cl-/HCO3/K+ prior to surgery
  • Require ETT (aspiration risk)
  • Orogastric tube and aspiration prior to induction of anaesthesia
  • Avoid opioid (risk of apnoea, CSF takes time to catch up to plasma levels)
  • Extubate awake in lateral position
18
Q

What is the presenting feature of pyloric stenosis?

A

Hypokalaemic, hypochloraemic metabolic alkalosis

Key to reversing this is chloride and volume
Only when chloride is given can the kidney excrete enough bicarbonate to correct the alkalosis

19
Q

What determines fetal oxygenation in utero?

A

—Delivery of O2 to the placenta - uteroplacental blood flow and maternal O2 content

—Fetal O2 carrying capacity (high Hb at birth ~180)

—Transfer of O2 across placenta:

  • O2 gradient
  • Higher O2 binding capacity of HbF
  • Double Bohr effect (CO2 shifting OHDC to the right in mother and left in fetus)
20
Q

What block could you perform for circumcision?

A

Caudal

Dorsal penile nerve block

21
Q

Describe a dorsal penile nerve block

A

Dorsal Nerve of Penis is from Pudendal nerve (S2-4)
Used for circumcision, hypospadias etc
Performed between pubic symphisis and corpora cavernosa

Dose = 1ml 0.5% levobupivacaine each side plus 0.1ml/kg up to 10ml

22
Q

Describe the anatomy and technique to perform a caudal epidural block for postoperative pain relief in a 3 year old. What volume and conc of agents will be required?

A
Sacral hiatus identified using the post.inf.iliac spines
Pop through sacrococcygeal membrane
Flatten off needle
Armitage formula:
—0.5ml/kg for sacral block
—1ml/kg for T10 block
—1.25ml/kg for mid thoracic block
23
Q

Where does the spinal cord end in children?

A

Dural sac ends at S3/4 in neonate

Spinal cord ends at L3 in neonates/infants

24
Q

How do you calculate fluid replacement in the dehydrated child?

A

Fluid replacement = weight x % dehydration x 10

25
Q

What are your obligations when suspecting child abuse or non-accidental injury/NAI?

A

Act in the child’s best interests
Be aware of the child’s right to protection
Respect confidentiality
Contact paediatrician
Be aware of local child protection mechanisms
Be aware of parent’s rights