Paediatric skin and allergy

Question 1

What is Stephens- Johnson syndrome?

Answer 1

a disproportional immune response causes epidermal necrosis, resulting in blistering and shedding of the top layer of skin

Question 2

What is another syndrome with ta similar pathology to Stephens-Johnson syndrome?

Answer 2

toxic epidermal necrolysis

Question 3

Which affects more than 10% of the body surface area, SJS or TEN?

Answer 3

TEN

Question 4

What genetics can make you more at risk of getting SJS or TEN?

Answer 4

HLA genetics

Question 5

What medications can cause SJS?

Answer 5

Anti-epileptics
Antibiotics
Allopurinol
NSAIDs

Question 6

What infections can cause SJS?

Answer 6

Herpes simplex
Mycoplasma pneumonia
Cytomegalovirus
HIV

Question 7

What are usually the first symptoms of SJS?

Answer 7

fever, cough, sore throat, sore mouth, sore eyes and itchy skin. They then develop a purple or red rash that spreads across the skin and starts to blister.