Paediatric Gastroenterology Flashcards

1
Q

Acute Abdomen

A

In half of children admitted, pain resolves undiagnosed; Appendicitis is far most common of surgical causes; Important to also look for Testes, Hernial Orifices and Hip Joints
• Important Medical Causes include – Lower Lobe Pneumonia, Primary Peritonitis (in patients with ascites), Diabetic Ketoacidosis, UTI (check Dipstick) and Pancreatitis (check Lipase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Surgical Causes of Acute Abdominal Pain

A
Acute appendicitis
Intestinal obstruction including intussusception 
Inguinal Hernia 
Peritonitis
Inflamed Meckel Diverticulum 
Pancreatitis 
Trauma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Medical Causes of Acute Abdominal Pain

A
Non specific abdominal pain 
Gastroenteritis 
Urinary Tract: UTI, acute pyelonephritis, hydronephrosis, renal calculus 
Diabetic Ketoacidosis
SCD
Hepatitis 
IBD
Constipation 
Recurrent Abdominal pain of childhood
Gynaecological in pubertal females
Psychological 
Lead poisoning 
Unknown
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Extraabdominal causes of Acute Abdomen

A

URTI
Lower lobe pneumonia
Torsion of testes
Hip and Spine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Uncomplicated Acute Appendicitis: Presentation

A

Uncommon under 3 years
Uncomplicated: Anorexia, vomiting, characteristic abdominal pain (central then colicky due to midgut colic then localising to RIF)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Complicated Acute Appendicitis: Presentation

A

Presence of Mass, Abscess or Perforation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Diagnosing Acute Appendicitis

A

Fever, Abdominal Pain aggravated by movement, Persistent Tenderness with RIF Guarding over McBurney’s Point; NB: If Pelvic Appendix, might have few abdominal signs
o Diagnosis more difficult in younger children, especially if early; Faecoliths more common and can be seen of AXR; Perforation more rapid as Omental is less developed, and signs are easy to underestimate
• Repeated observation and clinical review every few hours;
No laboratory investigation or imaging is consistently helpful in making diagnosis
o Neutrophilia not always present; Pyuria not uncommon due to proximity
o Ultrasound may support clinical diagnosis – Thickened, non-compressible Appendix, increased blood flow; Identify complications such as Abscess, Perforation or Mass
• Laparoscopy for diagnosis in some centres;

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Management of Appendicitis

A

Appendectomy is uncomplicated in appendicitis
• Perforation – Fluid resuscitation and Abx given prior to Laparotomy
• If palpable mass in RIF and no signs of Generalised Peritonitis, for Conservative Management with IV Abx and Appendectomy performed after several weeks; Laparotomy if persistent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Non specific Abdominal Pain

A

Abdominal Pain which resolves in 24-48hrs; Pain less severe than Appendicitis, and RIF tenderness is variable; Often accompanied with UTRI with Cervical LNA
o In some children, Abdominal signs do not resolve and Appendectomy performed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mesenteric Adenitis

A

Large Mesenteric LN seen on Laparoscopy, and Appendix normal; Although unsure if true diagnostic entity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Intussusception

A

Invagination of the Proximal Bowel into Distal Segment; Most commonly Ileum into Caecum through Ileocaecal valve; Peak age 3/12 – 2yrs;
o Most common cause of Obstruction in infants after Neonatal period

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Complications of Intussusception

A

Most serious complication is Vascular Compromise; Stretching and constriction of Mesentery leading to Venous Obstruction; Engorgement and Bleeding from Bowel Mucosa
o Leads to Bowel Perforation, Peritonitis and Gut Necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Presentation of Intussusception

A

Presents with Paroxysmal, Severe Colicky Pain with Pallor (especially Perioral); Recovery between episodes but eventual Lethargy; Anorexia, Vomit (might be Biliary), Sausage-shaped Mass often palpable; Redcurrant stool (Blood stained mucous; Characteristic, but tends to occur later and after PR examination); Distention and Shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Causes of Intussusception

A

Usually, no underlying cause found; Some evidence that viral illness leading to Peyer Hypertrophy related to Intussusception
o Identifiable lead points, such as Merkel’s Diverticulum or Polyp more likely if >2yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Investigating Intussusception

A

AXR shows distended Small Bowel and absence of gas in Distal Colon or Rectum
• Ultrasound useful for diagnosis (Target/Donut sign) and check response to treatment`

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Management of Intussusception

A

Managed by Rectal Air Insufflation if no Peritonitis signs; 75% success rate; Performed by radiologist in presence of paediatric surgeon in case of need for laparotomy
o Remaining 25% for Operative reduction; Overall Recurrence less than 5%
o Peritonism – Severe pain, Generalised Guarding/Rigidity, Rebound Tenderness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Merkel’s Diverticulum

A

Rule of twos: 2% of individuals have Ileal Remnant of Vitello-Intestinal Duct; 2 inches long, 2 feet from Ileocaecal valve, 2/3s contain ectopic tissue (Gastric or Panc), 2% symptomatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Presentation of Merkels Diverticulum

A

o Most asymptomatic, but can present with severe rectal bleeding; Acute ↓Hb
o Classically described as neither bright red, nor true Melaena
• Can also present as Intussusception, Volvulus or Diverticulitis (Mimics Appendicitis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Management of Merkel’s Diverticulum

A

o Tc scan – Increased uptake by ectopic gastric mucosa in 70% of cases
o Treatment by Surgical Resection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Malrotation

A

incomplete rotation of the bowel during foetal development leading to the formation of Ladd’s bands
There can be associated bowel infarction alongside obstruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Presentation of Malrotated Gut

A

Obstruction with Bilious vomiting is usual presentation in first few days of life; Requires urgent Upper GI Contrast study

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Management of Malrotation

A

Unless signs of vascular compromise = Urgent Laparotomy (Very unwell, Severe Abdominal Pain, Peritonism); Volvulus – SMA supply compromised, possibly leading to infarction
• Operative management – Volvulus resolved, Duodenum mobilised to Duodenojejunal Flexure; Caecum and Appendix placed into the left; This broadens the Mesentery
o Appendix generally removed if symptoms suggestive of appendicitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Inguinal Hernia

A

Common; 5% of boys, even more common in premature babies; Persistent Patent Processus Vaginalis; Emerges from Deep Inguinal Ring through Inguinal Canal = Indirect
o In Premature babies, Direct hernias more likely than in older children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How does an inguinal hernia present?

A

Presents as Lump in Groin, that may extend into Scrotum or Labia
o Typically, Asymptomatic; May be Intermittent, visible only during straining
o Often with Palpable lump, or thickened cord structures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Management of Inguinal Hernia
Most can be reduced by gentle compression along line of Inguinal Canal, with good Analgesia Irreducible Hernia = Incarcerated; Causing Pain, Intestinal Obstruction, or Testicular damage o Tender lump, Irritable Infant, Vomiting; Risk of Incarceration higher in infants than older children; If reduction impossible, Emergency surgery required • Surgery – Ligation and Division of Processus Vaginalis (=Herniotomy); C/f adults, Herniorrhaphy (Reinforcement of Inguinal Abdominal Wall e.g. Mesh
26
Umbilical Hernia
Hernia through Transversalis Fascia Umbilical ring; Size of base of herniated tissue inversely related to risk of strangulation • 3% of live-births; More common Afro-Carib, Down and Congenital Hypothyroidism o Surgical repair rarely needed (3 in 1000); at 3yrs spontaneous resolution
27
Paraumbilical Hernia
Herniation above or below Umbilicus; Crescent-shaping of Umbilicus o Only half of hernia fundus covered by umbilicus; Is an acquired defect • Neck of sac is narrow; Always requires surgery (Mayo repair)
28
Gastroschisis
Protrusion of Abdominal Contents through defect in Anterior Abdominal Wall right of the Umbilicus; Protruding bowel covered by thin ‘peel’ o Cautious Fluid Resuscitation followed by Prompt surgical repair o 4% associated with Congenital Heart Defects
29
Exomphalos (Omphacocoele)
Associated with other defects (Anencephaly, Cardiac, Hydrocephalus, Spinal Bifida); Abdominal contents outside of abdomen, covered by Peritoneum, Wharton’s Jelly and Amnion Less urgent repair than Gastroschisis due to protective membranes o Challenging repair – Need to fit organs into small abdominal cavity, without vascular or pulmonary compromise
30
Posseting
small amounts of milk that come with return of swallowed air
31
Regurgitation
larger, more frequent losses
32
Vomiting
Forceful ejection of gastric contents
33
Red Flags in Vomiting
Bile-stained, Haematemesis, Projectile Vomiting, Vomiting on Paroxysmal cough, Distention, Hepatosplenomegaly, Blood in stool, Severe dehydration/shock, Bulging Fontanelle or Focal Neurology, Faltering growth
34
Main causes of vomiting in the infant
Reflux, Infections (Gastroenteritis, URTI, Whooping cough, UTI, Meningitis), Food Allergies, Intolerance, Intestinal Obstruction (Pyloric Stenosis, Atresia, Intussusception, Malrotation, Volvulus, Strangulated Inguinal Hernia, Hirschsprung’s Disease)
35
Main causes of vomiting in preschool child
Infection, Appendicitis, Obstruction, Coeliac disease, Testicular Torsion
36
Main causes of school-aged child
Infection, Peptic Ulceration, Appendicitis, Migraine, Coeliac disease, DKA, Drugs/ETOH, Cyclical Vomiting Syndrome, Eating Disorders, Pregnancy, Testicular Torsion
37
GOR
Involuntary passage of gastric contents into the oesophagus; Extremely common in infancy due to inappropriate LOS relaxation due to functional immaturity o Predominantly fluid diet, mainly horizontal posture, short intra-abdominal length o Common in first year; nearly all symptomatic reflux resolves by 12/12 as sphincter matures, upright posture adopted and new diet • Many infants with GOR have recurrent regurgitation/vomiting, but put on weight normally and otherwise well; usually benign, self-limiting condition
38
When does GOR become GORD
Significant if it develops into Gastro-oesophageal Reflux Disease (GORD); More commonly in CP patients or with other neurodevelopmental disorders, pre-term infants, or following surgery for Oesophageal Atresia or CDH o GOR becomes GORD if Faltering Growth, Oesophagitis (Haematemesis, Heartburn, IDA), Recurrent Pulmonary Aspiration, Dystonic Neck Posturing (Sandifer Syndrome
39
Investigation of GORD
Clinical diagnosis, no investigations required Atypical history or no response to treatment: 24h Oesophageal pH monitoring, 24H Impedance monitoring, Endoscopy with Oesophageal Biopsies; Contrast studies not sensitive nor specific for GORD
40
Managing GORD
Parental reassurance, Inert thickening agents, feeding in smaller, more frequently • H2 Antagonists, Proton-Pump Inhibitors; poor evidence for drugs that increase gastric emptying (e.g. Domperidone); Consider cow’s milk protein allergy if non-responsive • Surgery if unresponsive to intensive medical therapy, or if Oesophageal Stricture o Nissen Fundoplication either open or laparoscopically
41
Pyloric Stenosis
Hypertrophy of Pylorus leading to Gastric Outlet Obstruction; Presents about 2-8/52 of age regardless of gestational age o 4× more common in boys; Particularly first-born; FMHx
42
Presentation of Pyloric Stenosis
Presents with Vomiting (Increasing Frequency and Forcefulness over time), Hunger after vomiting, Anorexia following Dehydration, Weight loss if delayed presentation o Excessive vomiting leads to Hypochloraemic Metabolic Alkalosis; May also be accompanied by Hyponatraemia, Hypokalaemia
43
Management of Pyloric Stenosis
Correction of Fluid and Electrolyte Disturbances with IV fluids • Definitive Pyloromyotomy once Hydrated, Acid Base and Electrolytes balanced o Division of Hypertrophied muscles down to mucosa; Either open procedure via Periumbilical incision, or Laparoscopic • Feeding can start within 6hrs post-op, Discharged within 2 days
44
Malabsorption in the child
Manifest as Abnormal stools (difficult to flush, foul odour), Poor weight gain/Faltering growth in most cases, or Specific Nutrient deficiencies o Some disorders affect small intestine or pancreas lead to pan-malabsorption, while other conditions are more specific e.g. Fat malabsorption with Biliary disorders
45
Coeliac Disease
Enteropathy caused by Gliadin (derived from Gluten and related Prolamines) provoking a damaging immune response against proximal Small Intestinal Mucosa; 1% population;
46
Risk Factors for Coeliac Disease
Higher risk if T1DM, Autoimmune Thyroid disease, Down syndrome, FMHx
47
Clinical Symptoms of Coeliac
Profound malabsorption 8/12 to 2yrs; Faltering growth, Distention, Buttock Wasting, Abnormal Stools and Irritability o Now more common to present as less acute in later childhood
48
Diagnosis of Coeliac
Positive serology (IgA Anti tTG, Anti EMA); Confirmation by Biopsy (Increased Intraepithelial Lymphocytes, Villous Atrophy, Crypt Hyperplasia), and resolution of symptoms following dietary change
49
Management of Coeliac
Removal of Wheat, Rye, Barley products from diet, under supervision of Dietitian; Gluten challenge in later childhood if initial biopsy or response to treatment doubtful o Non-adherence risks development of micronutrient deficiency, Osteopaenia, and small increased risk of malignancy (especially Small Bowel Lymphoma)
50
IBD in Children
25% present in childhood or adolescence; In children, Crohn’s is more common than UC (Opposite in adulthood) • IBD may result in poor general health, restricted growth and psychological adverse effects; Requires specialist MDT care
51
Presentation of Crohn's
Classic presentation of Abdominal Pain, Diarrhoea and Weight Loss; Febrile Lethargy, Oral lesions and Peri-anal Skin tags; Non-GI signs include Uveitis, Arthralgia and Erythema Nodosum; Can present without GI symptoms o Mistaken as psychological problems, anorexia nervosa Presence of Raised Inflammatory Markers (Platelets, ESR. CRP), Iron- deficiency Anaemia, and low Serum Albumin Transmural, Focal, Subacute or Chronic; Most commonly Terminal Ileum and Proximal Colon o Initially acutely inflamed, thickened bowel; Subsequently Strictures and Fistulae
52
Diagnosis of Crohn's
Endoscopy + Biopsy; Upper GI endoscopy, Colonoscopy and Small Bowel Imaging required (Crohn’s can affect any part of the GI tract) o Histology: Presence of Non-Caseating Epithelioid Cell Granulomata; although not present with 30% of patients initially o Imaging of Small Bowel might show Narrowing, Fissuring, Mucosal abnormalities and Bowel Wall Thickening
53
Management of Crohn's
Remission through Nutritional Therapy (Whole Protein Modular Feeds) for 6 – 8/52; Effective in 75% of cases; Systemic steroids if ineffective o Relapse is common – Steroid-sparing agents (Immunosuppressants) e.g. Azathioprine, Mercaptopurine or Methotrexate to maintain remission o Anti TNFa Mabs e.g. Infliximab, Adalimumab when conventional therapy fails o Long term enteric supplementation (e.g. Overnight feeds) help correct growth • Surgery – Obstruction, Fistulae, Abscess Formation, Severe resistant and localised disease
54
Ulcerative Colitis
Recurrent, Inflammatory and Ulcerating disease of the Colon Mucosa; Classic presentation of Rectal Bleeding, Diarrhoea and Colicky Pain; Weight Loss and Growth Failure may occur, although less frequently than in Crohn’s disease o Extra-intestinal complications include Erythema Nodosum and Arthritis
55
Diagnosis of UC
Endoscopy and Histology, to rule out infective causes o Confluent Colitis extended from Rectum proximally for variable length; 90% of children have Pancolitis (C/f adults, disease typically confined distally) o Histology: Mucosal Inflammation, Crypt damage, Ulceration o Small Bowel Imaging to rule out Crohn’s disease
56
Management of mild UC
Aminosalicylates (e.g. Mesalazine) for Induction and Maintenance o If only confined distally (rare in children) – Topical steroids
57
Management of more severe UC
Systemic Steroids for Acute Exacerbations, Immunosuppressants for Remission; Anti TNFa Mabs for resistant disease; If ineffective, Surgery should not be delayed • Severe Fulminating disease can progress to Toxic Megacolon; Medical emergency requiring IV fluids and Steroids; if remission still not achieved, Ciclosporin can be used • Surgery – Colectomy with Ileostomy, or Ileorectal Pouch • Increased incidence of Adenocarcinoma (0.5%/yr); Regular Colonoscopic screening 10yrs from diagnosis
58
Hirschsprung Disease
Absence of Ganglion cells from Myenteric and Submucosal Plexuses of part of the Large Bowel leads to Narrow, Contracted Segment o Extends from Rectum for variable distance proximally; Ending in normally innervated and dilated colon o 75% confined to Rectosigmoid, but 10% have entire colon involvement
59
Presentation of Hirschsprung Disease
Intestinal obstruction in Neonatal period, Failure to pass Meconium within first 24hrs o Abdominal distention, Bilious Vomiting o PR exam – Narrowed segment; Withdrawal of finger often leads to gush of liquid stool and flatus; Temporarily improves the obstruction • Can present as Severe, Life-threatening Hirschsprung Enterocolitis; In later childhood, might present as Chronic Constipation, Abdominal Distention; Growth failure might be present
60
Diagnosis of Hirschsprung's
Suction Rectal Biopsy – Absence of Ganglion cells and ACh-positive Nerve trunks; Anorectal Manometry and Barium studies unreliable for diagnosis but useful for surgical planning o Surgical management – Initial Colostomy, followed by Anastomosis of normally innervated bowel to anus