Paediatric Dermatoloy Flashcards

1
Q

Measles

A
  • Caused by measles virus
  • Spread by droplets
  • 14-day incubation period

Presentation

  • Fever, coryza and conjunctivitis
  • Day 3 - rash appears on face (discrete, maculopapular, behind ears) then spreads down body and becomes confluent
  • Cough present for whole illness
  • Koplik spots - pathognomic but rarely seen

Management

  • Notifiable disease
  • Isolate child and stay off school for 4 days after rash begins
  • Supportive treatment
  • Safety netting (SOB, altered consciousness, seizures)
  • Ribavarin for immunocompromised
  • Vaccinate

Complications

  • otitis media - most common complication
  • Pneumonia
  • Encephalitis and SSPE

Encephalitis

  • Headaches, seizures and irritability which progresses to seizures and coma
  • 15% mortality
  • Long term sequelae including deafness, LD

Sub-Sclerosing Pan Encephalitis

  • Occurs 7 years after measles infection
  • Caused by a variant of measles which persists in the CNS
  • Loss of neurological function which progresses to dementia and death
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2
Q

Scarlet fever

A
  • Characteristic red rash associated with toxin-producing strain of Strep (usually Strep A)

Presentation

  • Fine, punctate erythematous rash, most prominent in flexures
  • 3 S’s of Scarlet fever:
    1. Sparing of perioral area
    2. Strawberry tongue
    3. deSquamates

Investigations - none

Management

  • Erythromycin
  • Can return to school 24h after Abx start

Complications
- Rheumatic fever

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3
Q

Rubella

A
  • Caused by rubella virus
  • Incubation period 15-20 days

Presentation

  • Red, maculopapular rash begins on face and then spreads centrifugally down torso and arms
  • No fever (or low-grade)
  • Rash wanes after 3-5 days

Investigations

  • Serology - IgM ELISA done on all patients
  • Repeat in convalescent phase because of false positives

Management

  • No specific management, supportive only
  • Should resolve in 7-10 days
  • Avoid school for 4 days after rash starts, and avoid pregnant women

Complications

  • Thrombocytopenia with haemorrhage
  • Encephalitis
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4
Q

5th and 6th Disease

A

5th Disease - Erythema Infectiosum

  • Caused by PB19 infection, most common in sprint
  • 7 day coryza of fever, headache and myalgia
  • Maculopapular red rash on cheeks which progresses to lace-like rash on trunk and limbs

6th Disease - Roseola Infantum

  • Caused by HHV-6 and HHV-7
  • There is 2-3 day coryza
  • Generalised maculopapular rash begins as the fever wanes

Management of both

  • Supportive care only
  • Explain risk of febrile seizures
  • No need to stay off school
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5
Q

Nappy rash

A
  • Usually due to contact dermatitis due to irritant effects of urine
  • Can also be atopic eczema, Candida infection
  • In contact dermatitis the flexures are spared

Advice for parents

  • High absorbency, well-fitting nappies
  • Leave nappy off for as long as possible
  • Change nappy as soon as possible after child has soiled
  • Gently clean the area with water/fragrance free wipes and dry before fixing new nappy
  • Use barrier cream e.g. Castor oil ointment (available OTC/in supermarkets)

Management of complications

  • Inflammation - 1% hydrocortisone, only for infants >1 months, 7 days use max
  • Suspected bacterial infection - oral flucloxacillin
  • Suspected Candida infection - topical clomitrazole
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6
Q

Cradle cap

A
  • Infant sebhorreic dermatitis
  • Starts as an erythematous scaly eruption on the head
  • There can be a sticky adherent covering on the head (Cradle cap)
  • Rash may spread to face, axillae and napkin area

Management

  • Advise patients that it is common and usually resolves spontaneously by 8 months
  • They can use baby oil on the head, then use a soft brush to loosen the scales and wash with baby shampoo
  • If symptoms persist, can give topical clomitrazole to be used 2-3/day until symptoms disappear
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7
Q

Eczema

A
  • Common in children, usually presents in first year of life
  • Itch-scratch cycle - the child feels an itch, scratches it, this exacerbates the rash
  • Usually dry skin, excoriations and there can be lichenification

Management
- EMOLLIENTS!!
- Mild - 1% hydrocortisone for 48h
- Moderate - betametasone 0.025% for 48h for flare ups and 1% hydrocortisone for maintenance + non-sedating antihistamine – Follow up – if not better, check compliance, can refer to dermatology
Severe - Betamethasone 0.1% cream for flare ups and Bethamethasone 0.025% for face and flexures

Advice

  • Atopic march
  • Frequent and liberal use of emollients, even when skin is cleat
  • Keep nails short
  • If there are bowel symptoms, may refer to food allergy clinic for skin-prick testing
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8
Q

Guttate psoriasis

A
  • usually presents following a bacteria/viral URTI
  • There are red, scaly, drop-like plaques across the trunk and upper limbs
  • These resolve over 3-4 months
  • Tx with bland ointments
  • Can recur in 3-5 years
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9
Q

Molluscum contagiosum

A
  • Caused by poxvirus
  • Presents with skin-coloured pearly papules, with central umbilication
  • These are not harmful but can take 18 months to resolve
  • No management needed
  • Avoid sharing towels, clothing and baths
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10
Q

Pityriasis rosea

A
  • Cause unknown but thought to be related to HHV infection
  • There is an initial herald patch (red, scaly patch) which then develops into a widespread maculopapular rash
  • May or may not be itchy
  • Self-resolving in 4-6 weeks
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11
Q

Tinea

A
  • Invasions of dead keratinised structures with dermatophyte fungi
  • Can see fungal hyphae on skin scrapings microscopy
  • Tinea capitis - systemic antifungals + selenium silphide shampoo
  • Can otherwise give topical antifungal
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12
Q

Scabies

A
  • Caused by Sarcoptes scabei
  • Infection of the dermal layers down to the stratum corneum
  • Presents with intense itching, 2-6 weeks after exposure
  • In older children you may see burrows
  • Clinical diagnosis

Treatment

  • Permethrin 5% cream
  • Apply to whole body, starting at neck and shoulders and then moving downwards
  • Allow it to dry before putting on clothes
  • After 8-12 hours, wash off
  • Repeat treatment after 1 week
  • Wash and tumble dry all clothing to decontaminate
  • Treat close contacts
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13
Q

Pediculosis

A
  • Pediculosis capitis = headlice infestation
  • Treat with dimeticone 4% - apply and leave overnight, then wash out the next day
  • Repeat treatment if symptoms are still there one week later
  • Comb hair with fine-tooth comb to remove any live lice
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14
Q

Epidermolysis Bullosa

A
  • Genetic condition with blistering of the skin and mucous membranes
  • Blistering can be spontaneous or after minor trauma
  • AD can be fatal whereas AR is milder
  • There can be fusing of fingers and toes and limb contractures due to repeated healing and scarring
  • Ulceration in mucosal membranes can lead to oesophageal strictures and stenosis
  • Manage by avoiding minor trauma and treating secondary bacterial infections
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15
Q

Albinism

A
  • Failure in the biosynthesis and metabolism of melanin
  • Can be ocular, partial or oculocutaneous
  • Eye problems - failure to develop fixation reflex, photophobia (constant frowning), pendular nystagmus
  • Manage with sun protection and corrective glasses
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16
Q

Acne

A
  • Generally presents 1-2 years after androgenic stimulation
  • Androgens stimulate sebaceous glands to produce sebum
  • Open comedones (blackheads) and closed comedones (whiteheads)
  • May be related to menstruation

Mild-to-moderate acne

  • Topical single agent e.g. benzoyl peroxide
  • COCP may help in girls

Moderate acne, not responding to the above treatment

  • Abx e.g. Doxycycline
  • Give with another agent e.g. topical retinoid, to help prevent resistance
17
Q

Alopecia areata

A
  • Non-inflamed hairless areas
  • May see exclamation mark hairs (broken hairs)
  • Regrowth in 6-12 months
18
Q

Hereditary angioedema

A
  • AD condition with deficiency in C1 esterase, resulting in excess bradykinin
  • There is severe subcutaneous swelling and abdominal pain with no urticaria or pruritus
  • Usually triggered by stress
  • Episodes develop over hours and subside over days
  • There is risk to the airway, so can treat with purified preparation of C1 esterase inhibitor
19
Q

HSV infections in children

A

GINGIVOSTOMATITIS

  • Most common HSV infection in children
  • Causes painful, bleeding ulcers in the mouth and hard palate
  • High fever
  • Clinical diagnosis
  • There may be herpetic whitlows (white pustules near the fingers) from autoinoculation

Management

  • Mild cases - supportive treatment (anti-pyretics, fluids)
  • Severe disease - admission and IV aciclovir

ECZEMA HERPETICUM

  • HSV infection on a background of eczema
  • Causes crusted ulcer-like lesions
  • Mild disease - oral aciclovir
  • Moderate-severe disease - IV aciclovir
  • Antipyretics, hydration and supportive treatment
20
Q

VZV infection

A

CHICKENPOX

  • 14 day incubation period
  • Prodrome of 2-day fever, followed by eruptions of red, itchy papules on the head and torso, then spreading to the peripheries
  • These develop into vesicles and pustules and then crust over
  • Lesions of different stages are present at one time
  • Clinical diagnosis
  • Usually self-resolving with supportive treatment - hydration, soft cotton clothing, keep nails short
  • Can give oral aciclovir if child presents within 24h of rash appearing
  • Avoid school for 5-7 days after all lesions have crusted over
  • For immunocompromised, there is risk of disseminated infection so give IV aciclovir if affected, VZIG if exposed
  • Complications include pneumonia, hepatits, encephalitis
  • Chickenpox cerebellitis - chickenpox + ataxia, usually occurs early in illness and resolves in 1 month

SHINGLES

  • Reactivation of VZV infection
  • Lesions present in sensory dermotomal distribution
  • Uncommon in children, so consider an immunodeficiency
21
Q

CMV infection

A
  • In immunocompetent children, there is a mild disease resembling EBV mononucleosis
  • There is less prominent lymphadenopathy and heterophile monospot test negative
  • In immunocompromised children, there is disseminated disease which can present with pneumonia, retinitis, encephalitis, gastroenteritis and bone marrow failure
  • This needs treatment with IV ganciclovir
22
Q

Reye Syndrome

A
  • Rare complications linked to aspirin use following viral infection e.g. chickenpox
  • Presents with acute encephalopathy with sterile CSF, raised transaminases and liver biopsy showing fatty infiltrates
  • Can be fatal
23
Q

Hand, Foot and Mouth Disease

A
  • Caused by Coxsackie A16 virus
  • There are painful vesicles and ulcers on hands, feet, mouth and tongue
  • Mild systemic symptoms
  • Self-resolving in 3-4 days
  • Supportive treatment only
  • Can go to school as long as they well
24
Q

Bornholm Disease

A
  • Caused by Enterovirus
  • There is pleurodynia - chest pain
  • Self-resolving
25
Q

Herpangina

A
  • Caused by Coxsackie
  • Painful ulcers and vesicles in the mouth and vulval area
  • Severe cases may need IV aciclovir
26
Q

HIV in children

A
  • Causes T-cell (CD4+) suppression
  • Presents with variable levels of immunocompromise
  • Complications included Pneumocystis jiroveci, disseminated candidiasis, recurrent bacterial infections

Detection

  • Child <18 months - HIV PCR
  • Child >18 months - Serology

Management

  • Start ART early
  • Give SEPTRIN as PCP prophylaxis
  • Vaccinations (not live ones)
  • Regular monitoring of CD4 count and development

Advice for pregnant women

  • Comply with ART so that CD4 count is undetectable at time of delivery
  • Avoid breastfeeding
  • Newborns are given PEP
27
Q

Lyme Disease

A
  • Caused by Borellia burgdorferi
  • Spread by tick bites, although history is only present in 50% patients
  • The is an initial erythematous macule which progresses t erythema migrans (an enlarging lesions with red border)
  • There is systemic symptoms e.g. fever (fluctuating), lymphadenopathy and fatigue
  • Complications include joint complications, neurological symptoms and myocarditis

Investigations

  • Usually clinical diagnosis + serology
  • Where the history is unclear you can do ELISA to detect Borellia burgdorferi

Management

  • Resolves in weeks-months
  • 1st line is Doxycycline
28
Q

Kawasaki Disease

A
  • Vasculitis affecting the coronary arteries
  • Presents in children up to 6 years, Japanese children

CRASH + BURN

  • Conjunctivitis
  • Rash
  • Adenopathy
  • Strawberry tongue
  • Hand and feet involvement - desquamation after 1-2 weeks
  • BURN = fever that is difficult to control

Investigations

  • Clinical diagnosis
  • FBC, CRP
  • Thrombocytopenia after 2 weeks
  • Urgent echo

Management
- IVIG + high dose aspirin

Complications

  • Coronary artery aneurysms
  • There can be subsequent scarring and stenosis leading to potential myocardial ischaemia
29
Q

Henoch-Schonlein Purpura

A
  • Vasculitis
  • Inflammation of the capillaries
  • Usually post-URTI (more common in winter months

Presentation

  • Fever
  • Tetrad of rash, abdo pain, joint pain and glomerulonephritis
  • Rash - palpable purpura, non-blanching, affecting extensor surfaces of limbs and buttocks, trunk-sparing
  • Abdominal pain - may be severe colicky pain, intussusception
  • Joint pain - there may be joint oedema, swelling of the legs
  • Kidney involvement - haematuria/proteinuria

Investigations

  • Clinical diagnosis
  • Urinalysis
  • BP

Management

  • Supportive - analgesia, fluids, anti-pyretics
  • Steroids can be given for severe abdominal pain or proteinuria
  • Acute abdominal pain needs urgent surgical review for possible intussusception
  • Monitor BP and kidney function if there is kidney involvement

Usually resolves in 4-6 weeks