Paediatric Flashcards
what 1st investigations should you get in a child with neonatal jaundice
- transcutaneous bilirubinometer
- total serum bilirubin
- direct coombs test
- direct serum bilirubin
- haematocrit
- FBC
- Blood packed cell volume
- reticulocyte count
- peripheral blood smear
- blood group of mother and baby
- LFTs
- urine culture
- abdo US
- genetic testing
what questions should you ask about in a neonatal jaundice station
Gestational age <38 weeks
Previous sibling with neonatal jaundice requiring phototherapy
Mother’s intention to breastfeed exclusively
Visible jaundice in the first 24 hours of life
what investigations should you do in suspected biliary atresia?
Liver US
percutaneous biopsy
requires urgent Kasai procedure
when should you use serum bilirubin levels in neonatal jaundice?
in the first 24 hours of life or
who have a gestational age of less than 35 weeks.
What is the management of neonatal jaundice
Monitor transcuteanous bilirubin levels and plot on tx threshold graph
measure levels every 6 hours until bilirubin is below tx threshold and pt is stable
Monitor for signs of kernicterus - e.g. rapidly rising levels or features of acute bilirubin encephalopathy
Inform and support mum throughout - ensure breastfeeding, nappy changing and cuddles can continue + lactation support
Management = phototherapy (stop once 50 mmol below transfusino line) or exchange transfusion (counsel mum as baby needs transferred to intensive care bed
what does phototherapy do for baby?
converts the neurotoxic unconjugated bilirubin to a harmless, water-soluble isomer called lumirubin, which is readily excreted in the bile and urine
what should you ask in a failure to thrive station
ask to see growth charts and determine age of onset
- input - dietary and feeding hx
- use - energy, activity and exercise
- output - wet nappies, stool and GI sx
Others - bahviour, general health, happiness, parens health
what is the commonest cause of failure to thrive
not being offered enough food
what investigations would you get in suspected CF pts?
sweat test
immunoreactive trypsinogen (IRT test) in newborn
genetic testing
what is the management of cystic fibrosis
genetic disease with no cure, management is based on maintaining health and early tx of infections.
Resp - resp physio, positive exp pressure mask and use of abx to treat infections. NIV can be used to improve clearance techniques.
Salbutamol and mucolytics can be used.
chronic P. aeruginosa infections can be given inhaled abx. And prophylactically with azithromycin.
Early tx of infections
anti-inflammatory drugs such as alternate day steroids.
- CFTR modulators are beginning used
- lung transplant if exhausted all alternative methods
- treat pancreatic insufficiency with pancreatic enzyme replacement therapy and fat-soluble vitamin supplementation given before food + fat soluble vitamins
- monitor liver function
- risk of meconium ileus - give lactulose and surgery
- stool softeners, laxatives and hydration can be used to improve bowel habits and minimise recurrence
- tx the reflux
- monitor and optimise nutrition - high calorie diet
working down the body what are the characteristics of downs
face - dysmorphic features
neuro - developmental delay, autism and alzheimers (early onset)
heart - Arterioventricular septal defect
GI - duodenal atresia, Hirschsprungs
endocrine - Hypothyroid ,T1DM
Haem- ALL
what motor questions should you ask in motor for developmental delay
how mobile
hand dominence
balance
behavioural
what should you ask as part of language/social developmental delay
senses - hearing and vision
vocalisation/articulation
comprehension - follows commands, responds to voice
non-verbal communication - gestures, pointing
social responsiveness
what are key parts of the developmental hx
prenatal problems - e.g. alcohol drugs perinatal problems - prolonged labour - postnatal problems? meningitis etc general sx - fever, lalertness neuro sx - fits, loc , headache, weakness or wasting.
what are the TORCH infections of pregnancy
history of toxoplasosis/rubella/CMV/herpes
what does the pre-natal screening test do?
Screening tests along with other data such as maternal age, weight, family origin and gestation are combined in software to calculate the probability of a fetus having Down’s syndrome. The screening test is considered positive if the risk of a fetus having Down’s syndrome is greater than 1 in 150. If the screening test returns a positive result, women are offered diagnostic testing
what is the nuchal translucency in Downs?
increased
what are the serum screen results in downs
Beta-hCG: raised in Down’s syndrome
PAPPA-A: decreased in Down’s syndrome
Inhibin A - raised
the rest low
how do you describe non-invaseice prenatal testing
during pregnancy the placenta sheds some cells into mothers bloodstream. This blood from mum can be sampled and predict whether or not there is a risk of a chromosomal condtion.
how do you confirm downs
Karyotype analysis of fetal cells via chorionic villus sampling (9–12 weeks gestation) or amniocentesis (15–19 weeks gestation) is the gold standard for diagnosing Down’s syndrome, with equal detection rates of around 99%. There is a higher risk of pregnancy loss with chorionic villus sampling compared to amniocentesis.19
what post-natal screening should be performed in downs pts
Echocardiography: to screen for congenital cardiovascular abnormalities
Red reflex testing: to screen for congenital cataracts
TFTs: to screen for congenital thyroid disease
FBC: to screen for myeloproliferative disorders and polycythaemia
Hearing assessment: to screen for congenital hearing issues
Radiographic swallowing assessment: performed if feeding difficulties are present to screen for gastrointestinal abnormalities (e.g. duodenal atresia)
what is the management of downs
Management of Down’s syndrome requires a tailored multidisciplinary approach to screen, diagnose and treat complications. Patients with Down’s syndrome often require ongoing regular review from relevant specialists..
Early interventional therapies - physio, OT, SALT
Educational resources -
Hearing, eye, dental and follow up thyroid checks
Genetic counselling for parents.
how do you describe cerebral palsy
non-progressive disease of the brain originating during the antenatal, neonatal, or early postnatal period when brain neuronal connections are still evolving.
80% will have a motor impairment.
Other problems = feeding difficulty, speech problems, UI
how do you manage cerebral palsy
Management is multidisciplinary and includes occupational, physical, and speech therapy; neurology and neurosurgery; psychiatry; urology; ophthalmology; and orthopaedic, paediatric, dietary, and psychosocial services. Educational and vocational support is also needed.
Tx spasticity with oral medications - baclofen
Physical, occupational, and speech therapy address motor function, communication, and activities of daily living to prevent deformity and optimise independence and quality of life. Orthopaedic interventions address contractures, scoliosis, subluxing hips, and extremity deformity.
manage epilepsy
what should every child with cerebral palsy get?
An MRI brain - may show periventricular leukomalacia
what is the management of paediatric GORD
Safety net - if vomiting becomes projectile, bile stained or bloody, poor growth or persisits beyond 1 yr and come back
- referral for breastfeeding assessment if frequent regurg with distress
reduce feed volume to trial smaller more frequent amounts
- if persists can try feed thickeners or anti-regurg formulae
- option of trialling hydrolysed protein formula to rule out cows milk protein intolerance
- education - prone and lateral positions decrease reflux but increased risk od SIDs
- PPIs or H2 antagonists may be trialled
- enteral feeding if medical management unsuccessful
- Surgical management is uncommon - nissen fundoplication