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Which zone in adrenal is responsible for testosterone production
Zona retucularis
Testosterone in women causes
Increase sex drive and pubic hair growth
Causes of Addison disease are
Water house friedrichson syndrome
Water house friedrichson syndrome
Sudden increase in blood pressure causing vessels in adrenal gland to rupture causing ischemia
Addison disease
Chronic adrenal insufficiency
Due to auto immune distraction mainly
metastatic carcinoma or tuberculosis
Complications of Cushing Syndrome
Hyperkalemia
Hyponatremoa
Hypovolemia
Metabolic avidosis
Hypoglycemia
Hyperpigmentation on skin elbow and joints
Decrease sex drive in female
Addisonian crisis
Sudden need for aldosterone and cortisol
Ssx
Pain in leg back abs
Vomiting and diarrhea
Low bp
Loss of consciousness
Diagnosis
ACTH given as a test
Mgt of Addison
Aldosterone
Androgen
Cortisol
Water house Fredrick’s on is associated with which of the infection
Meningococcal infection associated with DIC
Management of water house Fredrick’s on
Antibiotics and fluid mgt
Adrenal crisis mgt
be treated immediately with high doses of glucocorticoids (e.g., hydrocortisone). In addition, intravenous fluid resuscitation with isotonic saline should be initiated and potential hypoglycemia should be corrected
Most common cause of primary adrenal insufficiency in western world is ?
Autoimmune adrenitis
Primary adrenal insufficiency
Fatigue, nausea, weight loss, orthostatic hypotension, and hyponatremia in a patient with low serum cortisol suggest adrenal insufficiency. The failure of cortisol to increase after ACTH stimulation test confirms the diagnosis. Certain clinical manifestations such as hyperpigmentation and hyperkalemia are only seen with primary adrenal insufficiency (Addison disease).
Cosyntropin stimulation test, also known as ACTH stimulation test
for suspected primary adrenal insufficiency. Serum cortisol levels are measured before and after the patient is given exogenous ACTH. In a patient with normal adrenal function, the cortisol levels should rise dramatically in response to the ACTH, whereas in a patient with primary adrenal insufficiency, cortisol levels should remain low.
