PACKRAT 2 misses Flashcards
Essential HTN
Normal: <120/80
Pre-HTN: 120-139/80-89
Stage 1 HTN: 140-159/90-99
Stage 2 HTN: >160/100
Essential: idiopathic etiology, + fhx
Secondary: 2/2 identifiable and correctable cause; suspect if refractory to anti-HTNs (renal artery stenosis / fibromuscular dysplasia or hyperaldosteronisim, coarctation)
Complications:
CV: CAD, HF
Neuro: TIA, CVA, aneurysm rupture, encephalopathy
Nephropathy
Optic: retinal hemorrhage, blindness, retinopathy
Exam:
fundo: 1)arterial narrowing, 2) AV nicking, 3) added hemorrhages and soft exudates, 4) Papilledema = malignant HTN
Tx: lifestyle modifications -wt loss: BMI 18.5-24.9, smoking cessation, Na restriction <2.4g/day -dash diet exercise >30min / day for most of week -limit alcohol consumption
Pharm:
-diuretics, ACE, ARB, CCB, BB, A-Blockers
HTN urgency: inc BP but no end-organ damage
Tx: dec BP (MAP) 25% in first 24-48 hrs with PO agents
HTN emergency: >220/120 and acute end-organ damage
Tx: decrease BP (MAP) by 10% first hour and additional 15% next 2-3 hrs using IV agents
Thiazide diuretics
HCTZ, chlorthalidone
Ind: initial TOC in uncomplicated HTN (then add ACE/ARB, CCB, or BB)
Mech: dec bl volume / pressure by decreasing Na/H2O reabsorption at distal diluting tubule and lowers Ca excretion
ADRs: Hyponatremia, Hypokalemia, hyperuricemia and hyperglycemia (Caution in DM and gout)
Loop Diuretics
Furosemide, Bumetanide
Ind: HTN, CHF, hypercalcemia, severe edema, mild renal dz
Mech: inhibit water transport across Loop of Henle –> increased H2O, Na, Cl, and K excretion
ADRs: volume depletion, hypokalemia/natremia/calcemia, hyperuricemia, hypochloremic metabolic alkalosis, hyperglycemia
CI in sulfa allergy
K-Sparking diuretics
Spironolactone, Amiloride, Eplerenone
Mech: inhibit aldosterone-mediated Na/H2O absorption
ADRs: hyperkalemia (gynecomastia with spironolactone)
CI renal failure and hyponatremia
Thrombophlebitis
Inflammation of superficial vein / thrombus; benign and self-limiting
CM assoc with IV cath, trauma, preg, varicose veins
Trousseau’s sign: migratory thrombophlebitis assoc with malig or vasculitis
S/s: tenderness, pain, induration, edema, erythema along course of superficial vein +/- palpable cord
Dx: US –> noncompressible vein with clot and vein wall thickening
Workup:
- hypercoag state
- migratory phlebitis: CA
Tx: supportive- elevation and warm compresses, NSAIDs, TEDs
Septic: IV PCN and AMG
Prinzmetal’s angina
coronary spasm –> transient ST elevations without MI
Pt: F >50 smoker +/- other vasospastic dz (migraines, Raynaud’s)
Sx: CP at rest in morning, with hyperventilation, emotional stress, or cold exposure
Dx:
EKG: +/- transient ST elevations, rapidly resolve with CCB and NTG
Angiography: no fixed stenotic lesion
Tx: CCB = DOC; nitrates PRN
stable angina
substernal CP d/t exertion 2/2 CAD
RFs: DM (CAD equivalent), Hyperlipidemia, smoking, HTN, male, >65 yo, fhx CAD, obese
Sx: substernal nonpleuritic CP +/- radiation lasting <30 min and relieved with rest or nitrates; d/t fixed artery stenosis
Angina equivalent: dyspnea, epigastric pain, shoulder pain
Dx:
EKG: St depression with exertion, T wave inversion, poor R wave progression, or normal
Stress test
Coronary angiography: GOLD STANDARD for definitive dx
Tx:
Pharm: nitrates, BB, CCB, ASA
Revascularization: PTCA, PCI, CABG
mitral valve prolapse
MC in young F with Marfan / Ehlers Danlos
Sx: MC asx -autonomic dysfct: CP, panic attacks; arrhythmia --> fatigue, palpitaitons, syncope, dizziness -progression: fatigue, dyspnea, PND, CHF -stroke, endocarditis, PVCs
Murmur: midsystolic ejection click at apex; may have midsystolic murmur of MR too
PE:
-narrow AP diameter, thin, HoTN, scoliosis, pectus excacatum
Tx: BB for autonomic dysfct, reasurrance in asx or mild sx
CHF
Acute decompensated HF with worsening of baseline sx characterized by pulmonary congestion, sympathetic activation, or CXR findings
CXR findings:
- cephalization of flow: increased vascular flow –> inc pulmonary venous pressure; seen when Pul capillary wedge pressure (PCWP) 12-18 mmHg (normal 6-12)
- Kerley B lines: linear markings in periphery of lower lung fields when PCWP 18-25 mmHg
Tx:
LMNOP: Lasix, Morphine, Nitrates, Oxygen, Position
rosacea
Et: unclear; persistent vasomotor instability with lesion formation
Triggers: EtOH, increased temp, hot drinks; hot / cold weather, hot baths, spicy food
Sx:
- acne-like rash with erythema, flushing, telengiectasia, skin thickening, papulopustules with burning and stinging
- absence of comedones distinguishes it from acne!
Tx: topical flagyl 1st line +/- clinidine for flushing; avoid triggers
Basal cell carcinoma
MC skin cancer; MC in fair-skinned with prolonged sun exposure, xeroderma
Slow growing with low invidence of mets
Sx:
flat firm airea with small raised translucent / pearly / waxy papule with central ulceration and raised rolled borders; friable +/- telengiectasia
Dx: punch / shave biopsy –> basophilic cells
Tx: electric desiccation / curettage = TOC or Mohs
Oral Candidiasis
dd
Lice
LL
Kaposi Sarcoma
KK
Psoriasis
PP
Contact Dermatitis
CC
Diabetic Ketoacidosis
DK
Pseudogou
PP
Subacute Thyroiditis
ST
Pituitary adenoma
PA
Diabetes Insipidus
DI
Serous Otitis Media
SOM
Optic Neuritis
ON