P450 Examples

Question 1

From the lecture, what drug class interferes with ACEIs for hypertension?

Answer 1

NSAIDs, causing more limited effect; NSAIDs have similar efefct on thiazides

Question 2

From the lecture, what drug class interferes with itraconazole for onchomycosis? What is the mechanism?

Answer 2

Prilosec/PPIs

Decreased substrate bioavailability

Question 3

From the lecture, what drug class interferes with amlodipine for hypertension? What is the mechanism?

Answer 3

Antituberculars (Rifampin)

P450 induction increasing clearance

Question 4

From the lecture, what drug class interferes with warfarin for DVT treatment post-valproate use? What is the mechanism?

Answer 4

Carbamazepine (carboxamide antiepileptic)

Increased clearance

Question 5

What common drugs can cause 3rd degree AV block when using metoprolol? What is the mechanism?

Answer 5

Acetaminophen and Paroxetine

Decreased clearance due to P450 inhibition

Question 6

What antidepressant is a potent P450 inducer when codeine is administered?

Answer 6

Paroxetine