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Proteoglycans/Glycoproteins > P/G > Flashcards

P/G Flashcards

1
Q

ECM composed of

A

Proteoglycans

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2
Q

Proteoglycans composed of

A

Glycoasminoglycans (GAGs) linked by central protein

Bottle brush formation

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3
Q

GAGs composed of

A

Negative charged sugars

Repeating disaccharide units = position 1 acidic sugar / position 2 amino sugar

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4
Q

Name GAG properties

A

Strong negative charge

Binds lots of water = gel like matrix

Reacts to compression with expel water
Reacts to relaxation with absorbing water

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5
Q

Most abundant GAG

A

Chondroitons (sulfated pos 4/6)

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6
Q

Chondroitons are found in

A

BLAC

Bone, Ligaments, Aorta, Carltilage

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7
Q

Keratan Sulfate I

A

GAG

Found in Cornea

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8
Q

Keratan Sulfate II

A

GAG

Found in CBC
Connective tissue, bone, cartilage

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9
Q

Dermatan Sulfate

A

GAG

Found in Skin, Blood, Heart valve

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10
Q

Heparan Sulfate

A

GAG

Found in BM, cell surfaces for recognition

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11
Q

Heparin

A

GAG

Anticoagulant

GAG with most sulfates and most Negative charge

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12
Q

Bottle Brush Structure

A

GAGs = neg charged
GAGs = hydrated
so they repel

Linked to central core protein

Make up proteoglycans which are connected to hyaluronic acid

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13
Q

Synthesis of Glucoronic acid

A

Glucose to UDP glucose

UDP glucose oxidized to UDP glucoranic acid

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14
Q

Synthesis of Amino sugars

A

Glucose to glucosamine 6-P

Glucosamine 6-P to UDP glucosamine

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15
Q

Hyaluronic acid

A

Not sulfated
Not covalently bond to protein
Made in ECM
Provides central stand for proteoglycan aggs

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16
Q

Hyaluronic acid found in

Hyaluronic acid facilitates cell migration in

A

Vitreous humor eye, joint fluid, cartilage, loose connective tissue

Embryogenesis
Morphogenesis
Wound repair

17
Q

Glycoproteins

A

Sugars with O link = serine or threonine

Sugars with N link = asparagine

18
Q

Mucins

A

Glycoproteins rich with carbs

O glycosylated

19
Q

Blood Types

A

O - no link to GalH
A - link to GalNAc
B - link to galactose
AB - mixture

20
Q

N Glycosylation of Proteins

A

Mann rich precursor bound to dolichol-pp

Precursor given to all proteins then modified later

Sugar N link via Argenine

21
Q

Transport of enzymes from Golgi to Lysosome

A

N Linked glycoproteins receive mannose 6-P marker via phoshpotransferase

Golgi has mannose 6-P receptors = binds lysosomal enzymes = packaged into vesicles = transport to lysosomes

22
Q

I Cell Disease

A

Lacks phospotransferase

Lack of mannose 6-P marker in lysosomes

No lysosomal enzymes in lysosome

lack of degradation = leads to accumulation of inclusion bodies (I bodies)

Proteoglycans/Glycoproteins (1 decks)

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