P-2

Question 1

what is the role of gut microbiota in the development of obesity

Answer 1

gut organisms metabolize the fiber and produce short chain fatty acids which is absorbed and binds to GPCR in white adipose tissue . It suppresses the insulin mediated glucose uptake

Question 2

What is GPCR

Answer 2

When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein’s α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type

Question 3

how does GPCR signalling work

Answer 3

There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway.[6]